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Alterations of Gut Mycobiota Profiles in Adenoma and Colorectal Cancer

Accumulating evidence indicates that gut microbiota dysbiosis contributes to colorectal cancer and adenoma. However, a few studies revealed the altered gut mycobiota architecture in colorectal cancer. The present study characterized the gut mycobiota profiles in adenoma and colorectal cancer patient...

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Autores principales: Gao, Renyuan, Xia, Kai, Wu, Minkang, Zhong, Hui, Sun, Jing, Zhu, Yin, Huang, Linsheng, Wu, Xiaocai, Yin, Lu, Yang, Rong, Chen, Chunqiu, Qin, Huanlong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908310/
https://www.ncbi.nlm.nih.gov/pubmed/35281451
http://dx.doi.org/10.3389/fcimb.2022.839435
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author Gao, Renyuan
Xia, Kai
Wu, Minkang
Zhong, Hui
Sun, Jing
Zhu, Yin
Huang, Linsheng
Wu, Xiaocai
Yin, Lu
Yang, Rong
Chen, Chunqiu
Qin, Huanlong
author_facet Gao, Renyuan
Xia, Kai
Wu, Minkang
Zhong, Hui
Sun, Jing
Zhu, Yin
Huang, Linsheng
Wu, Xiaocai
Yin, Lu
Yang, Rong
Chen, Chunqiu
Qin, Huanlong
author_sort Gao, Renyuan
collection PubMed
description Accumulating evidence indicates that gut microbiota dysbiosis contributes to colorectal cancer and adenoma. However, a few studies revealed the altered gut mycobiota architecture in colorectal cancer. The present study characterized the gut mycobiota profiles in adenoma and colorectal cancer patients by metagenomic sequencing. Malassezia restricta increased, while Leucoagaricus_sp_SymCcos and fungal_sp_ARF18 significantly decreased in adenoma. Phanerochaete_chrysosporium, Lachancea_waltii, and Aspergillus_rambellii were the top 3 fungi that were significantly enriched in colorectal cancer, while Candida_versatilis, Pseudocercospora_pini_densiflorae, and Candida_sp_JCM_15000 were dominant in the healthy controls. Thirteen fungi, ranked as critical biomarkers in diagnosing colorectal cancer, showed positive associations among all samples. Lachancea_waltii and Phanerochaete_chrysosporium showed the most significant association within CRC. The values of area under the receiver-operating characteristics curve (AUROC) of selected 13 mycobiota were 0.926 in the training model and 0.757 in the 10-fold validation model. Our study provided a reliable investigation of the alterations of gut mycobiota in the development of colorectal cancer and established a convincing diagnostic model for colorectal cancer, which might improve the treatment strategy for colorectal cancer in the future.
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spelling pubmed-89083102022-03-11 Alterations of Gut Mycobiota Profiles in Adenoma and Colorectal Cancer Gao, Renyuan Xia, Kai Wu, Minkang Zhong, Hui Sun, Jing Zhu, Yin Huang, Linsheng Wu, Xiaocai Yin, Lu Yang, Rong Chen, Chunqiu Qin, Huanlong Front Cell Infect Microbiol Cellular and Infection Microbiology Accumulating evidence indicates that gut microbiota dysbiosis contributes to colorectal cancer and adenoma. However, a few studies revealed the altered gut mycobiota architecture in colorectal cancer. The present study characterized the gut mycobiota profiles in adenoma and colorectal cancer patients by metagenomic sequencing. Malassezia restricta increased, while Leucoagaricus_sp_SymCcos and fungal_sp_ARF18 significantly decreased in adenoma. Phanerochaete_chrysosporium, Lachancea_waltii, and Aspergillus_rambellii were the top 3 fungi that were significantly enriched in colorectal cancer, while Candida_versatilis, Pseudocercospora_pini_densiflorae, and Candida_sp_JCM_15000 were dominant in the healthy controls. Thirteen fungi, ranked as critical biomarkers in diagnosing colorectal cancer, showed positive associations among all samples. Lachancea_waltii and Phanerochaete_chrysosporium showed the most significant association within CRC. The values of area under the receiver-operating characteristics curve (AUROC) of selected 13 mycobiota were 0.926 in the training model and 0.757 in the 10-fold validation model. Our study provided a reliable investigation of the alterations of gut mycobiota in the development of colorectal cancer and established a convincing diagnostic model for colorectal cancer, which might improve the treatment strategy for colorectal cancer in the future. Frontiers Media S.A. 2022-02-24 /pmc/articles/PMC8908310/ /pubmed/35281451 http://dx.doi.org/10.3389/fcimb.2022.839435 Text en Copyright © 2022 Gao, Xia, Wu, Zhong, Sun, Zhu, Huang, Wu, Yin, Yang, Chen and Qin https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Gao, Renyuan
Xia, Kai
Wu, Minkang
Zhong, Hui
Sun, Jing
Zhu, Yin
Huang, Linsheng
Wu, Xiaocai
Yin, Lu
Yang, Rong
Chen, Chunqiu
Qin, Huanlong
Alterations of Gut Mycobiota Profiles in Adenoma and Colorectal Cancer
title Alterations of Gut Mycobiota Profiles in Adenoma and Colorectal Cancer
title_full Alterations of Gut Mycobiota Profiles in Adenoma and Colorectal Cancer
title_fullStr Alterations of Gut Mycobiota Profiles in Adenoma and Colorectal Cancer
title_full_unstemmed Alterations of Gut Mycobiota Profiles in Adenoma and Colorectal Cancer
title_short Alterations of Gut Mycobiota Profiles in Adenoma and Colorectal Cancer
title_sort alterations of gut mycobiota profiles in adenoma and colorectal cancer
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908310/
https://www.ncbi.nlm.nih.gov/pubmed/35281451
http://dx.doi.org/10.3389/fcimb.2022.839435
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