Cargando…

Cepharanthine hydrochloride inhibits the Wnt/β-catenin/Hedgehog signaling axis in liver cancer

Cepharanthine, a biscoclaurine alkaloid isolated from the roots of Stephania cephalantha Hayata, has been reported to demonstrate antitumor activity across multiple cancer types; however, the mechanisms are still under investigation. High transcriptional responses by both the Hedgehog and Wnt pathwa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Su, Gui-Feng, Huang, Ze-Xiu, Huang, Deng-Liang, Chen, Peng-Xiao, Wang, Yao, Wang, Yi-Fei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2022
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908316/ https://www.ncbi.nlm.nih.gov/pubmed/35211762 http://dx.doi.org/10.3892/or.2022.8294

Ejemplares similares

Cepharanthine Hydrochloride Improves Cisplatin Chemotherapy and Enhances Immunity by Regulating Intestinal Microbes in Mice
por: Zhou, Pengjun, et al.
Publicado: (2019)

Activation of the Hedgehog and Wnt/β-Catenin Signaling Pathways in Basal Cell Carcinoma
por: Takada, Tomoaki
Publicado: (2021)

Pharmacological Activity of Cepharanthine
por: Liu, Ke, et al.
Publicado: (2023)

Wnt/β-Catenin Signaling in Liver Cancers
por: Wang, Wenhui, et al.
Publicado: (2019)

In vitro activity of cepharanthine hydrochloride against clinical wild-type and lamivudine-resistant hepatitis B virus isolates
por: Zhou, Yu-Bing, et al.
Publicado: (2012)

Wnt, Hedgehog and Junctional Armadillo/β-Catenin Establish Planar Polarity in the Drosophila Embryo
por: Colosimo, Pamela F., et al.
Publicado: (2006)

Downregulation of MDR1 Gene by Cepharanthine Hydrochloride Is Related to the Activation of c-Jun/JNK in K562/ADR Cells
por: Han, Li, et al.
Publicado: (2014)

Cepharanthine in Experimental Tuberculosis
por: Sirsi, M., et al.
Publicado: (1952)

Wnt/β-catenin and Hedgehog pathways are involved in the inflammatory effect of Interleukin 18 on rat chondrocytes
por: Bao, Jiapeng, et al.
Publicado: (2017)

The hedgehog and Wnt/β-catenin system machinery mediate myofibroblast differentiation of LR-MSCs in pulmonary fibrogenesis
por: Chen, Xiang, et al.
Publicado: (2018)

Activation of hedgehog signaling in mesenchymal stem cells induces cartilage and bone tumor formation via Wnt/β-Catenin
por: Deng, Qi, et al.
Publicado: (2019)

Hyperoside Attenuate Inflammation in HT22 Cells via Upregulating SIRT1 to Activities Wnt/β-Catenin and Sonic Hedgehog Pathways
por: Huang, Jin, et al.
Publicado: (2021)

In vitro antiplasmodial activity of cepharanthine
por: Desgrouas, Camille, et al.
Publicado: (2014)

γ-Catenin Overexpression in AML Patients May Promote Tumor Cell Survival via Activation of the Wnt/β-Catenin Axis
por: Qian, Jiejin, et al.
Publicado: (2020)

In vitro inhibitory effects of cepharanthine on human liver cytochrome P450 enzymes
por: Zhang, Xunge, et al.
Publicado: (2020)

Retracted: Downregulation of MDR1 Gene by Cepharanthine Hydrochloride Is Related to the Activation of c-Jun/JNK in K562/ADR Cells
por: International, BioMed Research
Publicado: (2016)

Using Rhodamine 123 Accumulation in CD8(+) Cells as a Surrogate Indicator to Study the P-Glycoprotein Modulating Effect of Cepharanthine Hydrochloride In Vivo
por: Li, Han, et al.
Publicado: (2011)

Wnt/β-Catenin Signaling and Obesity
por: Chen, Na, et al.
Publicado: (2018)

Spatiotemporal regulation of liver development by the Wnt/β-catenin pathway
por: Burke, Zoë D., et al.
Publicado: (2018)

miR‑122/SENP1 axis confers stemness and chemoresistance to liver cancer through Wnt/β‑catenin signaling
por: Dai, Jianbo, et al.
Publicado: (2023)

Pharmacological Effects and Clinical Prospects of Cepharanthine
por: Liang, Di, et al.
Publicado: (2022)

Cepharanthine hydrochloride reverses the mdr1 (P-glycoprotein)-mediated esophageal squamous cell carcinoma cell cisplatin resistance through JNK and p53 signals
por: Zhou, Pengjun, et al.
Publicado: (2017)

Self-Renewal and Pluripotency in Osteosarcoma Stem Cells’ Chemoresistance: Notch, Hedgehog, and Wnt/β-Catenin Interplay with Embryonic Markers
por: Martins-Neves, Sara R., et al.
Publicado: (2023)

Wnt/β-catenin signaling in cancers and targeted therapies
por: Yu, Fanyuan, et al.
Publicado: (2021)

KCTD9 inhibits the Wnt/β-catenin pathway by decreasing the level of β-catenin in colorectal cancer
por: Yao, Hanhui, et al.
Publicado: (2022)

Wnt-5/pipetail functions in vertebrate axis formation as a negative regulator of Wnt/β-catenin activity
por: Westfall, Trudi A., et al.
Publicado: (2003)

Dual activation of Hedgehog and Wnt/β-catenin signaling pathway caused by downregulation of SUFU targeted by miRNA-150 in human gastric cancer
por: Peng, Yin, et al.
Publicado: (2021)

Gallic Acid Suppressed Tumorigenesis by an LncRNA MALAT1-Wnt/β-Catenin Axis in Hepatocellular Carcinoma
por: Shi, Chuan-jian, et al.
Publicado: (2021)

Correction: Cepharanthine hydrochloride reverses the mdr1 (P-glycoprotein)-mediated esophageal squamous cell carcinoma cell cisplatin resistance through JNK and p53 signals
por: Zhou, Pengjun, et al.
Publicado: (2021)

The CK1δ/ϵ-Tip60 Axis Enhances Wnt/β-Catenin Signaling via Regulating β-Catenin Acetylation in Colon Cancer
por: Ning, Jiong, et al.
Publicado: (2022)

Triptonide Effectively Inhibits Wnt/β-Catenin Signaling via C-terminal Transactivation Domain of β-catenin
por: Chinison, Jessica, et al.
Publicado: (2016)

MicroRNA-200a suppresses the Wnt/β-catenin signaling pathway by interacting with β-catenin
por: SU, JUAN, et al.
Publicado: (2011)

WSB2 as a target of Hedgehog signaling promoted the malignant biological behavior of Xuanwei lung cancer through regulating Wnt/β-catenin signaling
por: Wei, Xueqiang, et al.
Publicado: (2020)

WNKs in Wnt/β-catenin signaling
por: Serysheva, Ekatherina, et al.
Publicado: (2014)

Alisol B 23-Acetate Increases the Antitumor Effect of Bufalin on Liver Cancer through Inactivating Wnt/β-Catenin Axis
por: Ye, Miaoqing, et al.
Publicado: (2022)

Nrf1 Is Endowed with a Dominant Tumor-Repressing Effect onto the Wnt/β-Catenin-Dependent and Wnt/β-Catenin-Independent Signaling Networks in the Human Liver Cancer
por: Chen, Jiayu, et al.
Publicado: (2020)

Cepharanthine Prevents Estrogen Deficiency-Induced Bone Loss by Inhibiting Bone Resorption
por: Zhou, Chen-he, et al.
Publicado: (2018)

Aberrant Activation of the WNT/β-Catenin Signaling Pathway in Lupus Nephritis
por: Wang, Xiao-dong, et al.
Publicado: (2014)

TAZ/Wnt-β-catenin/c-MYC axis regulates cystogenesis in polycystic kidney disease
por: Lee, Eun Ji, et al.
Publicado: (2020)

Apigenin-induced lysosomal degradation of β-catenin in Wnt/β-catenin signaling
por: Lin, Chung-Ming, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_35orej29utm7pdqch0dipasak7