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Sepsis and the Risks of Long-Term Renal Adverse Outcomes in Patients With Chronic Kidney Disease
BACKGROUND: Sepsis is known to cause renal function fluctuations during hospitalization, but whether these patients discharged from sepsis were still at greater risks of long-term renal adverse outcomes remains unknown. METHODS: From 2011 to 2018, we included 1,12,628 patients with chronic kidney di...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908417/ https://www.ncbi.nlm.nih.gov/pubmed/35280875 http://dx.doi.org/10.3389/fmed.2022.809292 |
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author | Ou, Shuo-Ming Lee, Kuo-Hua Tsai, Ming-Tsun Tseng, Wei-Cheng Chu, Yuan-Chia Tarng, Der-Cherng |
author_facet | Ou, Shuo-Ming Lee, Kuo-Hua Tsai, Ming-Tsun Tseng, Wei-Cheng Chu, Yuan-Chia Tarng, Der-Cherng |
author_sort | Ou, Shuo-Ming |
collection | PubMed |
description | BACKGROUND: Sepsis is known to cause renal function fluctuations during hospitalization, but whether these patients discharged from sepsis were still at greater risks of long-term renal adverse outcomes remains unknown. METHODS: From 2011 to 2018, we included 1,12,628 patients with chronic kidney disease (CKD) aged ≥ 20 years. The patients with CKD were further divided into 11,661 sepsis group and 1,00,967 non-sepsis group. The following outcome of interest was included: all-cause mortality, readmission for acute kidney injury, estimated glomerular filtration rate decline ≥50% or doubling of serum creatinine, and end-stage renal disease. RESULTS: After propensity score matching, the sepsis group was at higher risks of all-cause mortality [hazard ratio (HR) 1.39, 95% CI, 1.31–1.47], readmission for acute kidney injury (HR 1.67, 95% CI 1.58–1.76), eGFR decline ≥ 50% or doubling of serum creatinine (HR 3.34, 95% CI 2.78–4.01), and end-stage renal disease (HR 1.43, 95% CI 1.34–1.53) than non-sepsis group. CONCLUSIONS: Our study found that patients with CKD discharged from hospitalization for sepsis have higher risks of subsequent renal adverse events. |
format | Online Article Text |
id | pubmed-8908417 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89084172022-03-11 Sepsis and the Risks of Long-Term Renal Adverse Outcomes in Patients With Chronic Kidney Disease Ou, Shuo-Ming Lee, Kuo-Hua Tsai, Ming-Tsun Tseng, Wei-Cheng Chu, Yuan-Chia Tarng, Der-Cherng Front Med (Lausanne) Medicine BACKGROUND: Sepsis is known to cause renal function fluctuations during hospitalization, but whether these patients discharged from sepsis were still at greater risks of long-term renal adverse outcomes remains unknown. METHODS: From 2011 to 2018, we included 1,12,628 patients with chronic kidney disease (CKD) aged ≥ 20 years. The patients with CKD were further divided into 11,661 sepsis group and 1,00,967 non-sepsis group. The following outcome of interest was included: all-cause mortality, readmission for acute kidney injury, estimated glomerular filtration rate decline ≥50% or doubling of serum creatinine, and end-stage renal disease. RESULTS: After propensity score matching, the sepsis group was at higher risks of all-cause mortality [hazard ratio (HR) 1.39, 95% CI, 1.31–1.47], readmission for acute kidney injury (HR 1.67, 95% CI 1.58–1.76), eGFR decline ≥ 50% or doubling of serum creatinine (HR 3.34, 95% CI 2.78–4.01), and end-stage renal disease (HR 1.43, 95% CI 1.34–1.53) than non-sepsis group. CONCLUSIONS: Our study found that patients with CKD discharged from hospitalization for sepsis have higher risks of subsequent renal adverse events. Frontiers Media S.A. 2022-02-24 /pmc/articles/PMC8908417/ /pubmed/35280875 http://dx.doi.org/10.3389/fmed.2022.809292 Text en Copyright © 2022 Ou, Lee, Tsai, Tseng, Chu and Tarng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Ou, Shuo-Ming Lee, Kuo-Hua Tsai, Ming-Tsun Tseng, Wei-Cheng Chu, Yuan-Chia Tarng, Der-Cherng Sepsis and the Risks of Long-Term Renal Adverse Outcomes in Patients With Chronic Kidney Disease |
title | Sepsis and the Risks of Long-Term Renal Adverse Outcomes in Patients With Chronic Kidney Disease |
title_full | Sepsis and the Risks of Long-Term Renal Adverse Outcomes in Patients With Chronic Kidney Disease |
title_fullStr | Sepsis and the Risks of Long-Term Renal Adverse Outcomes in Patients With Chronic Kidney Disease |
title_full_unstemmed | Sepsis and the Risks of Long-Term Renal Adverse Outcomes in Patients With Chronic Kidney Disease |
title_short | Sepsis and the Risks of Long-Term Renal Adverse Outcomes in Patients With Chronic Kidney Disease |
title_sort | sepsis and the risks of long-term renal adverse outcomes in patients with chronic kidney disease |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908417/ https://www.ncbi.nlm.nih.gov/pubmed/35280875 http://dx.doi.org/10.3389/fmed.2022.809292 |
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