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Postnatal Development of Centrifugal Inputs to the Olfactory Bulb

Processing in primary sensory areas is influenced by centrifugal inputs from higher brain areas, providing information about behavioral state, attention, or context. Activity in the olfactory bulb (OB), the first central processing stage of olfactory information, is dynamically modulated by direct p...

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Autores principales: Kostka, Johanna K., Bitzenhofer, Sebastian H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908425/
https://www.ncbi.nlm.nih.gov/pubmed/35281496
http://dx.doi.org/10.3389/fnins.2022.815282
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author Kostka, Johanna K.
Bitzenhofer, Sebastian H.
author_facet Kostka, Johanna K.
Bitzenhofer, Sebastian H.
author_sort Kostka, Johanna K.
collection PubMed
description Processing in primary sensory areas is influenced by centrifugal inputs from higher brain areas, providing information about behavioral state, attention, or context. Activity in the olfactory bulb (OB), the first central processing stage of olfactory information, is dynamically modulated by direct projections from a variety of areas in adult mice. Despite the early onset of olfactory sensation compared to other senses, the development of centrifugal inputs to the OB remains largely unknown. Using retrograde tracing across development, we show that centrifugal projections to the OB are established during the postnatal period in an area-specific manner. While feedback projections from the piriform cortex (PIR) are already present shortly after birth, they strongly increase in number during postnatal development with an anterior-posterior gradient. Contralateral projections from the anterior olfactory nucleus (AON) are present at birth but only appeared postnatally for the nucleus of the lateral olfactory tract (nLOT). Numbers of OB projecting neurons from the lateral entorhinal cortex (LEC), ventral hippocampus, and cortical amygdala (CoA) show a sudden increase at the beginning of the second postnatal week and a delayed development compared to more anterior areas. These anatomical data suggest that limited top-down influence on odor processing in the OB may be present at birth, but strongly increases during postnatal development and is only fully established later in life.
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spelling pubmed-89084252022-03-11 Postnatal Development of Centrifugal Inputs to the Olfactory Bulb Kostka, Johanna K. Bitzenhofer, Sebastian H. Front Neurosci Neuroscience Processing in primary sensory areas is influenced by centrifugal inputs from higher brain areas, providing information about behavioral state, attention, or context. Activity in the olfactory bulb (OB), the first central processing stage of olfactory information, is dynamically modulated by direct projections from a variety of areas in adult mice. Despite the early onset of olfactory sensation compared to other senses, the development of centrifugal inputs to the OB remains largely unknown. Using retrograde tracing across development, we show that centrifugal projections to the OB are established during the postnatal period in an area-specific manner. While feedback projections from the piriform cortex (PIR) are already present shortly after birth, they strongly increase in number during postnatal development with an anterior-posterior gradient. Contralateral projections from the anterior olfactory nucleus (AON) are present at birth but only appeared postnatally for the nucleus of the lateral olfactory tract (nLOT). Numbers of OB projecting neurons from the lateral entorhinal cortex (LEC), ventral hippocampus, and cortical amygdala (CoA) show a sudden increase at the beginning of the second postnatal week and a delayed development compared to more anterior areas. These anatomical data suggest that limited top-down influence on odor processing in the OB may be present at birth, but strongly increases during postnatal development and is only fully established later in life. Frontiers Media S.A. 2022-02-24 /pmc/articles/PMC8908425/ /pubmed/35281496 http://dx.doi.org/10.3389/fnins.2022.815282 Text en Copyright © 2022 Kostka and Bitzenhofer. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Kostka, Johanna K.
Bitzenhofer, Sebastian H.
Postnatal Development of Centrifugal Inputs to the Olfactory Bulb
title Postnatal Development of Centrifugal Inputs to the Olfactory Bulb
title_full Postnatal Development of Centrifugal Inputs to the Olfactory Bulb
title_fullStr Postnatal Development of Centrifugal Inputs to the Olfactory Bulb
title_full_unstemmed Postnatal Development of Centrifugal Inputs to the Olfactory Bulb
title_short Postnatal Development of Centrifugal Inputs to the Olfactory Bulb
title_sort postnatal development of centrifugal inputs to the olfactory bulb
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908425/
https://www.ncbi.nlm.nih.gov/pubmed/35281496
http://dx.doi.org/10.3389/fnins.2022.815282
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