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Modifications of the Triaminoaryl Metabophore of Flupirtine and Retigabine Aimed at Avoiding Quinone Diimine Formation

[Image: see text] The potassium channel opening drugs flupirtine and retigabine have been withdrawn from the market due to occasional drug-induced liver injury (DILI) and tissue discoloration, respectively. While the mechanism underlying DILI after prolonged flupirtine use is not entirely understood...

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Detalles Bibliográficos
Autores principales:	Wurm, Konrad W., Bartz, Frieda-Marie, Schulig, Lukas, Bodtke, Anja, Bednarski, Patrick J., Link, Andreas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908504/ https://www.ncbi.nlm.nih.gov/pubmed/35284765 http://dx.doi.org/10.1021/acsomega.1c07103

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