An integrative gene expression signature analysis identifies CMS4 KRAS-mutated colorectal cancers sensitive to combined MEK and SRC targeted therapy

BACKGROUND: Over half of colorectal cancers (CRCs) are hard-wired to RAS/RAF/MEK/ERK pathway oncogenic signaling. However, the promise of targeted therapeutic inhibitors, has been tempered by disappointing clinical activity, likely due to complex resistance mechanisms that are not well understood. T...

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Detalles Bibliográficos
Autores principales: Yang, Mingli, Davis, Thomas B., Pflieger, Lance, Nebozhyn, Michael V., Loboda, Andrey, Wang, Heiman, Schell, Michael J., Thota, Ramya, Pledger, W. Jack, Yeatman, Timothy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908604/
https://www.ncbi.nlm.nih.gov/pubmed/35272617
http://dx.doi.org/10.1186/s12885-022-09344-3

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