Subtypes in pancreatic ductal adenocarcinoma based on niche factor dependency show distinct drug treatment responses

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is characterized by abundant stroma in which microenvironmental (niche) factors promote PDAC progression. In mouse models, reduction of the stroma increased the proportion of poorly differentiated PDAC with a worse prognosis. Here, we aimed to clar...

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Detalles Bibliográficos
Autores principales: Shinkawa, Tomohiko, Ohuchida, Kenoki, Mochida, Yuki, Sakihama, Kukiko, Iwamoto, Chika, Abe, Toshiya, Ideno, Noboru, Mizuuchi, Yusuke, Shindo, Koji, Ikenaga, Naoki, Moriyama, Taiki, Nakata, Kohei, Oda, Yoshinao, Nakamura, Masafumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908673/
https://www.ncbi.nlm.nih.gov/pubmed/35272688
http://dx.doi.org/10.1186/s13046-022-02301-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908673/
https://www.ncbi.nlm.nih.gov/pubmed/35272688
http://dx.doi.org/10.1186/s13046-022-02301-9

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