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Tumors carrying BRAF-mutations over-express NAMPT that is genetically amplified and possesses oncogenic properties

BACKGROUND: Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in nicotinamide adenine dinucleotide (NAD) biosynthesis, is up-regulated in several cancers, including metastatic melanoma (MM). The BRAF oncogene is mutated in different cancer types, among which MM and thyroid car...

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Detalles Bibliográficos
Autores principales:	Audrito, Valentina, Moiso, Enrico, Ugolini, Filippo, Messana, Vincenzo Gianluca, Brandimarte, Lorenzo, Manfredonia, Ilaria, Bianchi, Simonetta, De Logu, Francesco, Nassini, Romina, Szumera-Ciećkiewicz, Anna, Taverna, Daniela, Massi, Daniela, Deaglio, Silvia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908704/ https://www.ncbi.nlm.nih.gov/pubmed/35272691 http://dx.doi.org/10.1186/s12967-022-03315-9

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