Cargando…

Tumors carrying BRAF-mutations over-express NAMPT that is genetically amplified and possesses oncogenic properties

BACKGROUND: Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in nicotinamide adenine dinucleotide (NAD) biosynthesis, is up-regulated in several cancers, including metastatic melanoma (MM). The BRAF oncogene is mutated in different cancer types, among which MM and thyroid car...

Descripción completa

Detalles Bibliográficos
Autores principales:	Audrito, Valentina, Moiso, Enrico, Ugolini, Filippo, Messana, Vincenzo Gianluca, Brandimarte, Lorenzo, Manfredonia, Ilaria, Bianchi, Simonetta, De Logu, Francesco, Nassini, Romina, Szumera-Ciećkiewicz, Anna, Taverna, Daniela, Massi, Daniela, Deaglio, Silvia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908704/ https://www.ncbi.nlm.nih.gov/pubmed/35272691 http://dx.doi.org/10.1186/s12967-022-03315-9

Ejemplares similares

NAMPT Over-Expression Recapitulates the BRAF Inhibitor Resistant Phenotype Plasticity in Melanoma
por: Audrito, Valentina, et al.
Publicado: (2020)

NAMPT and NAPRT: Two Metabolic Enzymes With Key Roles in Inflammation
por: Audrito, Valentina, et al.
Publicado: (2020)

Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) is a novel marker for patients with BRAF-mutated metastatic melanoma
por: Audrito, Valentina, et al.
Publicado: (2018)

A Fast and Automated Melanin-bleaching Method for Histopathologic Evaluation of Pigmented Melanoma Tissues
por: Ugolini, Filippo, et al.
Publicado: (2022)

The Extracellular NADome Modulates Immune Responses
por: Audrito, Valentina, et al.
Publicado: (2021)

The TRPA1 Channel Amplifies the Oxidative Stress Signal in Melanoma
por: De Logu, Francesco, et al.
Publicado: (2021)

Recognition of Cutaneous Melanoma on Digitized Histopathological Slides via Artificial Intelligence Algorithm
por: De Logu, Francesco, et al.
Publicado: (2020)

Differential HLA class I subunit (A, B, C heavy chain and β(2)-microglobulin) expression levels in normal tissues
por: Ugolini, Filippo, et al.
Publicado: (2022)

PD-L1 up-regulation in melanoma increases disease aggressiveness and is mediated through miR-17-5p
por: Audrito, Valentina, et al.
Publicado: (2017)

Digital Quantification of Intratumoral CD8+ T-Cells Predicts Relapse and Unfavorable Outcome in Uveal Melanoma
por: Hurdogan, Ozge, et al.
Publicado: (2022)

TRPA1 Expression in Synovial Sarcoma May Support Neural Origin
por: De Logu, Francesco, et al.
Publicado: (2020)

The dual face of NAMPT: Intracellular/extracellular protein and diagnostic/therapeutic target in cancer
por: Audrito, Valentina
Publicado: (2020)

Digital Immunophenotyping Predicts Disease Free and Overall Survival in Early Stage Melanoma Patients
por: De Logu, Francesco, et al.
Publicado: (2021)

Endothelial eNAMPT amplifies pre-clinical acute lung injury: efficacy of an eNAMPT-neutralising monoclonal antibody
por: Quijada, Hector, et al.
Publicado: (2021)

NAD-Biosynthetic and Consuming Enzymes as Central Players of Metabolic Regulation of Innate and Adaptive Immune Responses in Cancer
por: Audrito, Valentina, et al.
Publicado: (2019)

NAD/NAMPT and mTOR Pathways in Melanoma: Drivers of Drug Resistance and Prospective Therapeutic Targets
por: Indini, Alice, et al.
Publicado: (2022)

TRPA1 as a therapeutic target for nociceptive pain
por: Souza Monteiro de Araujo, Daniel, et al.
Publicado: (2020)

Sirtuin1, not NAMPT, possesses anti-inflammatory effects in epicardial, pericardial and subcutaneous adipose tissue in patients with CHD
por: Opstad, Trine Baur, et al.
Publicado: (2023)

Metabolic Interplay between the Immune System and Melanoma Cells: Therapeutic Implications
por: Indini, Alice, et al.
Publicado: (2021)

Linkage of NAMPT promoter variants to eNAMPT secretion, plasma eNAMPT levels, and ARDS severity
por: Lynn, Heather, et al.
Publicado: (2023)

The Role of TRPA1 in Skin Physiology and Pathology
por: Maglie, Roberto, et al.
Publicado: (2021)

TRPA1 Role in Inflammatory Disorders: What Is Known So Far?
por: Landini, Lorenzo, et al.
Publicado: (2022)

TRP Channels in Cancer: Signaling Mechanisms and Translational Approaches
por: Marini, Matilde, et al.
Publicado: (2023)

Enhanced NAMPT-Mediated NAD Salvage Pathway Contributes to Psoriasis Pathogenesis by Amplifying Epithelial Auto-Inflammatory Circuits
por: Mercurio, Laura, et al.
Publicado: (2021)

Migraine-provoking substances evoke periorbital allodynia in mice
por: De Logu, Francesco, et al.
Publicado: (2019)

Efficacy of Neoadjuvant Targeted Therapy for Borderline Resectable III B-D or IV Stage BRAF (V600) Mutation-Positive Melanoma
por: Czarnecka, Anna M., et al.
Publicado: (2021)

The NAMPT inhibitor FK866 reverts the damage in spinal cord injury
por: Esposito, Emanuela, et al.
Publicado: (2012)

Bright-Field Multiplex Immunohistochemistry Assay for Tumor Microenvironment Evaluation in Melanoma Tissues
por: Ugolini, Filippo, et al.
Publicado: (2022)

Expression and Regulation of Nampt in Human Islets
por: Kover, Karen, et al.
Publicado: (2013)

Regulation of Regenerative Periodontal Healing by NAMPT
por: Nokhbehsaim, Marjan, et al.
Publicado: (2013)

Visfatin/Nampt: An Adipokine with Cardiovascular Impact
por: Romacho, Tania, et al.
Publicado: (2013)

Association of Nicotinamide Phosphoribosyltransferase (NAMPT) Gene Polymorphisms and of Serum NAMPT Levels with Dilated Cardiomyopathy in a Chinese Population
por: Dou, Qingyu, et al.
Publicado: (2015)

Endothelial eNAMPT drives EndMT and preclinical PH: rescue by an eNAMPT-neutralizing mAb
por: Ahmed, Mohamed, et al.
Publicado: (2021)

Chemistry-led investigations into the mode of action of NAMPT activators, resulting in the discovery of non-pyridyl class NAMPT activators
por: Tang, Siyuan, et al.
Publicado: (2023)

Acetaldehyde via CGRP receptor and TRPA1 in Schwann cells mediates ethanol-evoked periorbital mechanical allodynia in mice: relevance for migraine
por: Landini, Lorenzo, et al.
Publicado: (2023)

β2-and β3-Adrenergic Receptors Contribute to Cancer-Evoked Pain in a Mouse Model of Osteosarcoma via Modulation of Neural Macrophages
por: Bruno, Gennaro, et al.
Publicado: (2021)

The Role of Pathology-Based Methods in Qualitative and Quantitative Approaches to Cancer Immunotherapy
por: Kuczkiewicz-Siemion, Olga, et al.
Publicado: (2022)

Regulation of NAMPT in Human Gingival Fibroblasts and Biopsies
por: Damanaki, Anna, et al.
Publicado: (2014)

Chemosensitization of leukemia cells through inhibition of NAMPT
por: Gorski, Theresa, et al.
Publicado: (2014)

Review of various NAMPT inhibitors for the treatment of cancer
por: Wei, Yichen, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ptm2mi61tnilgr4enbfnl3pi8s