Functional vulnerability of liver macrophages to capsules defines virulence of blood-borne bacteria

Many encapsulated bacteria use capsules to cause invasive diseases. However, it remains largely unknown how the capsules enhance bacterial virulence under in vivo infection conditions. Here we show that the capsules primarily target the liver to enhance bacterial survival at the onset of blood-borne...

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Detalles Bibliográficos
Autores principales: An, Haoran, Qian, Chenyun, Huang, Yijia, Li, Jing, Tian, Xianbin, Feng, Jiaying, Hu, Jiao, Fang, Yujie, Jiao, Fangfang, Zeng, Yuna, Huang, Xueting, Meng, Xianbin, Liu, Xue, Lin, Xin, Zeng, Zhutian, Guilliams, Martin, Beschin, Alain, Chen, Yongwen, Wu, Yuzhang, Wang, Jing, Oggioni, Marco Rinaldo, Leong, John, Veening, Jan-Willem, Deng, Haiteng, Zhang, Rong, Wang, Hui, Wu, Jiang, Cui, Yan, Zhang, Jing-Ren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908791/
https://www.ncbi.nlm.nih.gov/pubmed/35258552
http://dx.doi.org/10.1084/jem.20212032

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