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Touch and Go: Membrane Contact Sites Between Lipid Droplets and Other Organelles
Lipid droplets (LDs) have emerged not just as storage sites for lipids but as central regulators of metabolism and organelle quality control. These critical functions are achieved, in part, at membrane contact sites (MCS) between LDs and other organelles. MCS are sites of transfer of cellular consti...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908909/ https://www.ncbi.nlm.nih.gov/pubmed/35281095 http://dx.doi.org/10.3389/fcell.2022.852021 |
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author | Liao, Pin-Chao Yang, Emily J. Borgman, Taylor Boldogh, Istvan R. Sing, Cierra N. Swayne, Theresa C. Pon, Liza A. |
author_facet | Liao, Pin-Chao Yang, Emily J. Borgman, Taylor Boldogh, Istvan R. Sing, Cierra N. Swayne, Theresa C. Pon, Liza A. |
author_sort | Liao, Pin-Chao |
collection | PubMed |
description | Lipid droplets (LDs) have emerged not just as storage sites for lipids but as central regulators of metabolism and organelle quality control. These critical functions are achieved, in part, at membrane contact sites (MCS) between LDs and other organelles. MCS are sites of transfer of cellular constituents to or from LDs for energy mobilization in response to nutrient limitations, as well as LD biogenesis, expansion and autophagy. Here, we describe recent findings on the mechanisms underlying the formation and function of MCS between LDs and mitochondria, ER and lysosomes/vacuoles and the role of the cytoskeleton in promoting LD MCS through its function in LD movement and distribution in response to environmental cues. |
format | Online Article Text |
id | pubmed-8908909 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89089092022-03-11 Touch and Go: Membrane Contact Sites Between Lipid Droplets and Other Organelles Liao, Pin-Chao Yang, Emily J. Borgman, Taylor Boldogh, Istvan R. Sing, Cierra N. Swayne, Theresa C. Pon, Liza A. Front Cell Dev Biol Cell and Developmental Biology Lipid droplets (LDs) have emerged not just as storage sites for lipids but as central regulators of metabolism and organelle quality control. These critical functions are achieved, in part, at membrane contact sites (MCS) between LDs and other organelles. MCS are sites of transfer of cellular constituents to or from LDs for energy mobilization in response to nutrient limitations, as well as LD biogenesis, expansion and autophagy. Here, we describe recent findings on the mechanisms underlying the formation and function of MCS between LDs and mitochondria, ER and lysosomes/vacuoles and the role of the cytoskeleton in promoting LD MCS through its function in LD movement and distribution in response to environmental cues. Frontiers Media S.A. 2022-02-24 /pmc/articles/PMC8908909/ /pubmed/35281095 http://dx.doi.org/10.3389/fcell.2022.852021 Text en Copyright © 2022 Liao, Yang, Borgman, Boldogh, Sing, Swayne and Pon. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Liao, Pin-Chao Yang, Emily J. Borgman, Taylor Boldogh, Istvan R. Sing, Cierra N. Swayne, Theresa C. Pon, Liza A. Touch and Go: Membrane Contact Sites Between Lipid Droplets and Other Organelles |
title | Touch and Go: Membrane Contact Sites Between Lipid Droplets and Other Organelles |
title_full | Touch and Go: Membrane Contact Sites Between Lipid Droplets and Other Organelles |
title_fullStr | Touch and Go: Membrane Contact Sites Between Lipid Droplets and Other Organelles |
title_full_unstemmed | Touch and Go: Membrane Contact Sites Between Lipid Droplets and Other Organelles |
title_short | Touch and Go: Membrane Contact Sites Between Lipid Droplets and Other Organelles |
title_sort | touch and go: membrane contact sites between lipid droplets and other organelles |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908909/ https://www.ncbi.nlm.nih.gov/pubmed/35281095 http://dx.doi.org/10.3389/fcell.2022.852021 |
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