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Physiological health indexes predict deterioration and mortality in patients with COVID-19: a comparative study

Old age is a crucial risk factor for severe coronavirus disease 2019 (COVID-19), with serious or fatal outcomes disproportionately affecting older adults compared with the rest of the population. We proposed that the physiological health status and biological age, beyond the chronological age itself...

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Autores principales: Strazhesko, Irina, Tkacheva, Olga, Kashtanova, Daria, Ivanov, Mikhail, Kljashtorny, Vladislav, Esakova, Antonina, Karnaushkina, Maria, Guillemette, Cassandra, Hewett, Amber, Legault, Véronique, Maytesian, Lilit, Litvinova, Maria, Cohen, Alan, Moskalev, Alexey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908924/
https://www.ncbi.nlm.nih.gov/pubmed/35213841
http://dx.doi.org/10.18632/aging.203915
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author Strazhesko, Irina
Tkacheva, Olga
Kashtanova, Daria
Ivanov, Mikhail
Kljashtorny, Vladislav
Esakova, Antonina
Karnaushkina, Maria
Guillemette, Cassandra
Hewett, Amber
Legault, Véronique
Maytesian, Lilit
Litvinova, Maria
Cohen, Alan
Moskalev, Alexey
author_facet Strazhesko, Irina
Tkacheva, Olga
Kashtanova, Daria
Ivanov, Mikhail
Kljashtorny, Vladislav
Esakova, Antonina
Karnaushkina, Maria
Guillemette, Cassandra
Hewett, Amber
Legault, Véronique
Maytesian, Lilit
Litvinova, Maria
Cohen, Alan
Moskalev, Alexey
author_sort Strazhesko, Irina
collection PubMed
description Old age is a crucial risk factor for severe coronavirus disease 2019 (COVID-19), with serious or fatal outcomes disproportionately affecting older adults compared with the rest of the population. We proposed that the physiological health status and biological age, beyond the chronological age itself, could be the driving trends affecting COVID-19 severity and mortality. A total of 155 participants hospitalized with confirmed COVID-19 aged 26–94 years were recruited for the study. Four different physiological summary indices were calculated: Klemera and Doubal’s biological age, PhenoAge, physiological dysregulation (PD; globally and in specific systems), and integrated albunemia. All of these indices significantly predicted the risk of death (p < 0.01) after adjusting for chronological age and sex. In all models, men were 2.4–4.4-times more likely to die than women. The global PD was shown to be a good predictor of deterioration, with the odds of deterioration increasing by 41.7% per 0.5-unit increase in the global PD. As for death, the odds also increased by 68.3% per 0.5-unit increase in the global PD. Our results are partly attributed to common chronic diseases that aggravate COVID-19, but they also suggest that the underlying physiological state could capture vulnerability to severe COVID-19 and serve as a tool for prognosis that would, in turn, help inpatient management.
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spelling pubmed-89089242022-03-11 Physiological health indexes predict deterioration and mortality in patients with COVID-19: a comparative study Strazhesko, Irina Tkacheva, Olga Kashtanova, Daria Ivanov, Mikhail Kljashtorny, Vladislav Esakova, Antonina Karnaushkina, Maria Guillemette, Cassandra Hewett, Amber Legault, Véronique Maytesian, Lilit Litvinova, Maria Cohen, Alan Moskalev, Alexey Aging (Albany NY) Research Paper Old age is a crucial risk factor for severe coronavirus disease 2019 (COVID-19), with serious or fatal outcomes disproportionately affecting older adults compared with the rest of the population. We proposed that the physiological health status and biological age, beyond the chronological age itself, could be the driving trends affecting COVID-19 severity and mortality. A total of 155 participants hospitalized with confirmed COVID-19 aged 26–94 years were recruited for the study. Four different physiological summary indices were calculated: Klemera and Doubal’s biological age, PhenoAge, physiological dysregulation (PD; globally and in specific systems), and integrated albunemia. All of these indices significantly predicted the risk of death (p < 0.01) after adjusting for chronological age and sex. In all models, men were 2.4–4.4-times more likely to die than women. The global PD was shown to be a good predictor of deterioration, with the odds of deterioration increasing by 41.7% per 0.5-unit increase in the global PD. As for death, the odds also increased by 68.3% per 0.5-unit increase in the global PD. Our results are partly attributed to common chronic diseases that aggravate COVID-19, but they also suggest that the underlying physiological state could capture vulnerability to severe COVID-19 and serve as a tool for prognosis that would, in turn, help inpatient management. Impact Journals 2022-02-25 /pmc/articles/PMC8908924/ /pubmed/35213841 http://dx.doi.org/10.18632/aging.203915 Text en Copyright: © 2022 Strazhesko et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Strazhesko, Irina
Tkacheva, Olga
Kashtanova, Daria
Ivanov, Mikhail
Kljashtorny, Vladislav
Esakova, Antonina
Karnaushkina, Maria
Guillemette, Cassandra
Hewett, Amber
Legault, Véronique
Maytesian, Lilit
Litvinova, Maria
Cohen, Alan
Moskalev, Alexey
Physiological health indexes predict deterioration and mortality in patients with COVID-19: a comparative study
title Physiological health indexes predict deterioration and mortality in patients with COVID-19: a comparative study
title_full Physiological health indexes predict deterioration and mortality in patients with COVID-19: a comparative study
title_fullStr Physiological health indexes predict deterioration and mortality in patients with COVID-19: a comparative study
title_full_unstemmed Physiological health indexes predict deterioration and mortality in patients with COVID-19: a comparative study
title_short Physiological health indexes predict deterioration and mortality in patients with COVID-19: a comparative study
title_sort physiological health indexes predict deterioration and mortality in patients with covid-19: a comparative study
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908924/
https://www.ncbi.nlm.nih.gov/pubmed/35213841
http://dx.doi.org/10.18632/aging.203915
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