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Downregulated exosome-associated gene FGF9 as a novel diagnostic and prognostic target for ovarian cancer and its underlying roles in immune regulation
Exosome has been demonstrated to be secreted from cells and seized by targeted cells. Exosome could transmit signals and exert biological functions in cancer progression. Nevertheless, the underlying mechanisms of exosome in ovarian cancer (OC) have not been fully explored. In this study, we wanted...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908935/ https://www.ncbi.nlm.nih.gov/pubmed/35190498 http://dx.doi.org/10.18632/aging.203905 |
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author | Xu, Zhijie Cai, Yuan Liu, Wei Kang, Fanhua He, Qingchun Hong, Qianhui Zhang, Wenqin Li, Jianbo Yan, Yuanliang Peng, Jinwu |
author_facet | Xu, Zhijie Cai, Yuan Liu, Wei Kang, Fanhua He, Qingchun Hong, Qianhui Zhang, Wenqin Li, Jianbo Yan, Yuanliang Peng, Jinwu |
author_sort | Xu, Zhijie |
collection | PubMed |
description | Exosome has been demonstrated to be secreted from cells and seized by targeted cells. Exosome could transmit signals and exert biological functions in cancer progression. Nevertheless, the underlying mechanisms of exosome in ovarian cancer (OC) have not been fully explored. In this study, we wanted to explore whether Fibroblast growth factor 9 (FGF9), as an exosome-associated gene, was importantly essential in OC progression and prognosis. Firstly, comprehensive bioinformatics platforms were applied to find that FGF9 expression was lower in OC tissues compared to normal ovarian tissues. Meanwhile, downregulated FGF9 displayed favorable prognostic values in OC patients. The gene enrichment of biological functions indicated that abnormally expressed FGF9 could be involved in the OC-related immune signatures, such as immunoinhibitors and chemokine receptors. Taken together, these findings could provide a novel insight into the significance of FGF9 in OC progress and supply a new destination of FGF9-related immunotherapy in clinical treatment. |
format | Online Article Text |
id | pubmed-8908935 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-89089352022-03-11 Downregulated exosome-associated gene FGF9 as a novel diagnostic and prognostic target for ovarian cancer and its underlying roles in immune regulation Xu, Zhijie Cai, Yuan Liu, Wei Kang, Fanhua He, Qingchun Hong, Qianhui Zhang, Wenqin Li, Jianbo Yan, Yuanliang Peng, Jinwu Aging (Albany NY) Research Paper Exosome has been demonstrated to be secreted from cells and seized by targeted cells. Exosome could transmit signals and exert biological functions in cancer progression. Nevertheless, the underlying mechanisms of exosome in ovarian cancer (OC) have not been fully explored. In this study, we wanted to explore whether Fibroblast growth factor 9 (FGF9), as an exosome-associated gene, was importantly essential in OC progression and prognosis. Firstly, comprehensive bioinformatics platforms were applied to find that FGF9 expression was lower in OC tissues compared to normal ovarian tissues. Meanwhile, downregulated FGF9 displayed favorable prognostic values in OC patients. The gene enrichment of biological functions indicated that abnormally expressed FGF9 could be involved in the OC-related immune signatures, such as immunoinhibitors and chemokine receptors. Taken together, these findings could provide a novel insight into the significance of FGF9 in OC progress and supply a new destination of FGF9-related immunotherapy in clinical treatment. Impact Journals 2022-02-21 /pmc/articles/PMC8908935/ /pubmed/35190498 http://dx.doi.org/10.18632/aging.203905 Text en Copyright: © 2022 Xu et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Xu, Zhijie Cai, Yuan Liu, Wei Kang, Fanhua He, Qingchun Hong, Qianhui Zhang, Wenqin Li, Jianbo Yan, Yuanliang Peng, Jinwu Downregulated exosome-associated gene FGF9 as a novel diagnostic and prognostic target for ovarian cancer and its underlying roles in immune regulation |
title | Downregulated exosome-associated gene FGF9 as a novel diagnostic and prognostic target for ovarian cancer and its underlying roles in immune regulation |
title_full | Downregulated exosome-associated gene FGF9 as a novel diagnostic and prognostic target for ovarian cancer and its underlying roles in immune regulation |
title_fullStr | Downregulated exosome-associated gene FGF9 as a novel diagnostic and prognostic target for ovarian cancer and its underlying roles in immune regulation |
title_full_unstemmed | Downregulated exosome-associated gene FGF9 as a novel diagnostic and prognostic target for ovarian cancer and its underlying roles in immune regulation |
title_short | Downregulated exosome-associated gene FGF9 as a novel diagnostic and prognostic target for ovarian cancer and its underlying roles in immune regulation |
title_sort | downregulated exosome-associated gene fgf9 as a novel diagnostic and prognostic target for ovarian cancer and its underlying roles in immune regulation |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908935/ https://www.ncbi.nlm.nih.gov/pubmed/35190498 http://dx.doi.org/10.18632/aging.203905 |
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