Targeted Agents in the Treatment of Indolent B-Cell Non-Hodgkin Lymphomas

SIMPLE SUMMARY: New therapies for lymphoma continue to be developed at a rapid rate, including for the indolent lymphomas. While traditional cytotoxic chemotherapy remains an effective treatment option, many new treatments target specific aspects of cancer cells such as surface proteins or signaling pathways with the aim of providing a more personalized and tailored approach. By doing so, targeted agents can interrupt cancer cell growth and development, make cancer cells more susceptible to other treatments, or direct the immune system to recognize and destroy cancer cells. This review highlights and discusses the currently available and emerging targeted therapies that apply to follicular lymphoma, lymphoplasmacytic lymphoma/Waldenstrom macroglublinaemia and marginal zone lymphoma. ABSTRACT: Targeted therapies continue to change the landscape of lymphoma treatment, resulting in improved therapy options and patient outcomes. Numerous agents are now approved for use in the indolent lymphomas and many others under development demonstrate significant promise. In this article, we review the landscape of targeted agents that apply to the indolent lymphomas, predominantly follicular lymphoma, lymphoplasmacytic lymphoma/Waldenstrom macroglobulinaemia and marginal zone lymphoma. The review covers small molecule inhibitors, immunomodulators and targeted immunotherapies, as well as presenting emerging and promising combination therapies.