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Schwann Cells in Digestive System Disorders

Proper functioning of the digestive system is ensured by coordinated action of the central and peripheral nervous systems (PNS). Peripheral innervation of the digestive system can be viewed as intrinsic and extrinsic. The intrinsic portion is mainly composed of the neurons and glia of the enteric ne...

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Detalles Bibliográficos
Autores principales: Goluba, Karina, Kunrade, Liga, Riekstina, Una, Parfejevs, Vadims
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908985/
https://www.ncbi.nlm.nih.gov/pubmed/35269454
http://dx.doi.org/10.3390/cells11050832
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author Goluba, Karina
Kunrade, Liga
Riekstina, Una
Parfejevs, Vadims
author_facet Goluba, Karina
Kunrade, Liga
Riekstina, Una
Parfejevs, Vadims
author_sort Goluba, Karina
collection PubMed
description Proper functioning of the digestive system is ensured by coordinated action of the central and peripheral nervous systems (PNS). Peripheral innervation of the digestive system can be viewed as intrinsic and extrinsic. The intrinsic portion is mainly composed of the neurons and glia of the enteric nervous system (ENS), while the extrinsic part is formed by sympathetic, parasympathetic, and sensory branches of the PNS. Glial cells are a crucial component of digestive tract innervation, and a great deal of research evidence highlights the important status of ENS glia in health and disease. In this review, we shift the focus a bit and discuss the functions of Schwann cells (SCs), the glial cells of the extrinsic innervation of the digestive system. For more context, we also provide information on the basic findings regarding the function of innervation in disorders of the digestive organs. We find diverse SC roles described particularly in the mouth, the pancreas, and the intestine. We note that most of the scientific evidence concerns the involvement of SCs in cancer progression and pain, but some research identifies stem cell functions and potential for regenerative medicine.
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spelling pubmed-89089852022-03-11 Schwann Cells in Digestive System Disorders Goluba, Karina Kunrade, Liga Riekstina, Una Parfejevs, Vadims Cells Review Proper functioning of the digestive system is ensured by coordinated action of the central and peripheral nervous systems (PNS). Peripheral innervation of the digestive system can be viewed as intrinsic and extrinsic. The intrinsic portion is mainly composed of the neurons and glia of the enteric nervous system (ENS), while the extrinsic part is formed by sympathetic, parasympathetic, and sensory branches of the PNS. Glial cells are a crucial component of digestive tract innervation, and a great deal of research evidence highlights the important status of ENS glia in health and disease. In this review, we shift the focus a bit and discuss the functions of Schwann cells (SCs), the glial cells of the extrinsic innervation of the digestive system. For more context, we also provide information on the basic findings regarding the function of innervation in disorders of the digestive organs. We find diverse SC roles described particularly in the mouth, the pancreas, and the intestine. We note that most of the scientific evidence concerns the involvement of SCs in cancer progression and pain, but some research identifies stem cell functions and potential for regenerative medicine. MDPI 2022-02-28 /pmc/articles/PMC8908985/ /pubmed/35269454 http://dx.doi.org/10.3390/cells11050832 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Goluba, Karina
Kunrade, Liga
Riekstina, Una
Parfejevs, Vadims
Schwann Cells in Digestive System Disorders
title Schwann Cells in Digestive System Disorders
title_full Schwann Cells in Digestive System Disorders
title_fullStr Schwann Cells in Digestive System Disorders
title_full_unstemmed Schwann Cells in Digestive System Disorders
title_short Schwann Cells in Digestive System Disorders
title_sort schwann cells in digestive system disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908985/
https://www.ncbi.nlm.nih.gov/pubmed/35269454
http://dx.doi.org/10.3390/cells11050832
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