Role of Polo-like Kinases Plk1 and Plk4 in the Initiation of Centriole Duplication—Impact on Cancer

Centrosomes nucleate and anchor microtubules and therefore play major roles in spindle formation and chromosome segregation during mitosis. Duplication of the centrosome occurs, similar to DNA, only once during the cell cycle. Aberration of the centrosome number is common in human tumors. At the cor...

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Detalles Bibliográficos
Autor principal: Hoffmann, Ingrid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908989/
https://www.ncbi.nlm.nih.gov/pubmed/35269408
http://dx.doi.org/10.3390/cells11050786
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author Hoffmann, Ingrid
author_facet Hoffmann, Ingrid
author_sort Hoffmann, Ingrid
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description Centrosomes nucleate and anchor microtubules and therefore play major roles in spindle formation and chromosome segregation during mitosis. Duplication of the centrosome occurs, similar to DNA, only once during the cell cycle. Aberration of the centrosome number is common in human tumors. At the core of centriole duplication is the conserved polo-like kinase 4, Plk4, and two structural proteins, STIL and Sas-6. In this review, I summarize and discuss developments in our understanding of the first steps of centriole duplication and their regulation.
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spelling pubmed-89089892022-03-11 Role of Polo-like Kinases Plk1 and Plk4 in the Initiation of Centriole Duplication—Impact on Cancer Hoffmann, Ingrid Cells Review Centrosomes nucleate and anchor microtubules and therefore play major roles in spindle formation and chromosome segregation during mitosis. Duplication of the centrosome occurs, similar to DNA, only once during the cell cycle. Aberration of the centrosome number is common in human tumors. At the core of centriole duplication is the conserved polo-like kinase 4, Plk4, and two structural proteins, STIL and Sas-6. In this review, I summarize and discuss developments in our understanding of the first steps of centriole duplication and their regulation. MDPI 2022-02-24 /pmc/articles/PMC8908989/ /pubmed/35269408 http://dx.doi.org/10.3390/cells11050786 Text en © 2022 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hoffmann, Ingrid
Role of Polo-like Kinases Plk1 and Plk4 in the Initiation of Centriole Duplication—Impact on Cancer
title Role of Polo-like Kinases Plk1 and Plk4 in the Initiation of Centriole Duplication—Impact on Cancer
title_full Role of Polo-like Kinases Plk1 and Plk4 in the Initiation of Centriole Duplication—Impact on Cancer
title_fullStr Role of Polo-like Kinases Plk1 and Plk4 in the Initiation of Centriole Duplication—Impact on Cancer
title_full_unstemmed Role of Polo-like Kinases Plk1 and Plk4 in the Initiation of Centriole Duplication—Impact on Cancer
title_short Role of Polo-like Kinases Plk1 and Plk4 in the Initiation of Centriole Duplication—Impact on Cancer
title_sort role of polo-like kinases plk1 and plk4 in the initiation of centriole duplication—impact on cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908989/
https://www.ncbi.nlm.nih.gov/pubmed/35269408
http://dx.doi.org/10.3390/cells11050786
work_keys_str_mv AT hoffmanningrid roleofpololikekinasesplk1andplk4intheinitiationofcentrioleduplicationimpactoncancer

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