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The Effects of Fucoidan Dietary Supplementation on Growth Performance, Serum Antioxidant Capacity, Immune Function Indices and Intestinal Morphology in Weaned Kids
SIMPLE SUMMARY: During the weaning period, the change of feed and separation from ewe induce weaning stress and may affect the growth and health of kids. The application of antibiotics could relieve weaning stress; however, their prophylactic application coerces researchers to find antibiotic altern...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8909077/ https://www.ncbi.nlm.nih.gov/pubmed/35268143 http://dx.doi.org/10.3390/ani12050574 |
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author | Yang, Weiguang Chen, Jiayi Guo, Guangzhen Wang, Shengnan Peng, Su Gao, Zhenhua Zhao, Zhihui Lan, Ruixia Yin, Fuquan |
author_facet | Yang, Weiguang Chen, Jiayi Guo, Guangzhen Wang, Shengnan Peng, Su Gao, Zhenhua Zhao, Zhihui Lan, Ruixia Yin, Fuquan |
author_sort | Yang, Weiguang |
collection | PubMed |
description | SIMPLE SUMMARY: During the weaning period, the change of feed and separation from ewe induce weaning stress and may affect the growth and health of kids. The application of antibiotics could relieve weaning stress; however, their prophylactic application coerces researchers to find antibiotic alternatives to relieve weaning stress. Fucoidan is a natural plant extract widely used in animal production with antioxidant and immune-modulatory properties resulting in beneficial effects on the intestinal tract. In the present study, fucoidan dietary supplementation boosted antioxidant and immune functions, improved the morphology of the intestinal tract and promoted the growth performance of kids. These results indicated that fucoidan could be used to alleviate weaning stress in kids. ABSTRACT: The purpose of this study was to evaluate the effects of fucoidan dietary supplementation on growth performance, organs’ relative weight, serum anti-oxidation markers, immune function indices and intestinal morphology in weaned kids. A total of 60 2-month-old weaned castrated male kids (Chuanzhong black goat) were used for this 30-day experiment and randomly allocated to four groups. The control group (CON) fed a basal diet, while the other three groups were provided with the same diet further supplemented with fucoidan at 0.1%, 0.3% or 0.5%, namely, F1, F2 and F3 groups, respectively. The results indicated that dietary fucoidan supplementation significantly increased (p < 0.05) the activity of catalase (CAT) when compared to the CON group on day 15. Moreover, the addition of fucoidan at 0.3% and 0.5% significantly increased (p < 0.05) the activities of glutathione peroxidase (GSH-Px) and total superoxide dismutase (T-SOD). On day 30, dietary fucoidan supplementation significantly reduced (p < 0.05) the feed conversion rate (FCR), contents of tumor necrosis-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6), while it significantly increased (p < 0.05) the activity of total superoxide dismutase (T-SOD), the content of immunoglobulin G (IgG) and the villus height (VH) of the duodenum. Moreover, dietary 0.3% and 0.5% fucoidan supplementation significantly increased (p < 0.05) the villus height (VH) of the jejunum and ileum and significantly reduced (p < 0.05) the crypt depth (CD) of ileum. In conclusion, dietary fucoidan had positive effects on growth performance, serum anti-oxidation, immune function and intestinal morphology of weaned kids. |
format | Online Article Text |
id | pubmed-8909077 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89090772022-03-11 The Effects of Fucoidan Dietary Supplementation on Growth Performance, Serum Antioxidant Capacity, Immune Function Indices and Intestinal Morphology in Weaned Kids Yang, Weiguang Chen, Jiayi Guo, Guangzhen Wang, Shengnan Peng, Su Gao, Zhenhua Zhao, Zhihui Lan, Ruixia Yin, Fuquan Animals (Basel) Article SIMPLE SUMMARY: During the weaning period, the change of feed and separation from ewe induce weaning stress and may affect the growth and health of kids. The application of antibiotics could relieve weaning stress; however, their prophylactic application coerces researchers to find antibiotic alternatives to relieve weaning stress. Fucoidan is a natural plant extract widely used in animal production with antioxidant and immune-modulatory properties resulting in beneficial effects on the intestinal tract. In the present study, fucoidan dietary supplementation boosted antioxidant and immune functions, improved the morphology of the intestinal tract and promoted the growth performance of kids. These results indicated that fucoidan could be used to alleviate weaning stress in kids. ABSTRACT: The purpose of this study was to evaluate the effects of fucoidan dietary supplementation on growth performance, organs’ relative weight, serum anti-oxidation markers, immune function indices and intestinal morphology in weaned kids. A total of 60 2-month-old weaned castrated male kids (Chuanzhong black goat) were used for this 30-day experiment and randomly allocated to four groups. The control group (CON) fed a basal diet, while the other three groups were provided with the same diet further supplemented with fucoidan at 0.1%, 0.3% or 0.5%, namely, F1, F2 and F3 groups, respectively. The results indicated that dietary fucoidan supplementation significantly increased (p < 0.05) the activity of catalase (CAT) when compared to the CON group on day 15. Moreover, the addition of fucoidan at 0.3% and 0.5% significantly increased (p < 0.05) the activities of glutathione peroxidase (GSH-Px) and total superoxide dismutase (T-SOD). On day 30, dietary fucoidan supplementation significantly reduced (p < 0.05) the feed conversion rate (FCR), contents of tumor necrosis-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6), while it significantly increased (p < 0.05) the activity of total superoxide dismutase (T-SOD), the content of immunoglobulin G (IgG) and the villus height (VH) of the duodenum. Moreover, dietary 0.3% and 0.5% fucoidan supplementation significantly increased (p < 0.05) the villus height (VH) of the jejunum and ileum and significantly reduced (p < 0.05) the crypt depth (CD) of ileum. In conclusion, dietary fucoidan had positive effects on growth performance, serum anti-oxidation, immune function and intestinal morphology of weaned kids. MDPI 2022-02-24 /pmc/articles/PMC8909077/ /pubmed/35268143 http://dx.doi.org/10.3390/ani12050574 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Yang, Weiguang Chen, Jiayi Guo, Guangzhen Wang, Shengnan Peng, Su Gao, Zhenhua Zhao, Zhihui Lan, Ruixia Yin, Fuquan The Effects of Fucoidan Dietary Supplementation on Growth Performance, Serum Antioxidant Capacity, Immune Function Indices and Intestinal Morphology in Weaned Kids |
title | The Effects of Fucoidan Dietary Supplementation on Growth Performance, Serum Antioxidant Capacity, Immune Function Indices and Intestinal Morphology in Weaned Kids |
title_full | The Effects of Fucoidan Dietary Supplementation on Growth Performance, Serum Antioxidant Capacity, Immune Function Indices and Intestinal Morphology in Weaned Kids |
title_fullStr | The Effects of Fucoidan Dietary Supplementation on Growth Performance, Serum Antioxidant Capacity, Immune Function Indices and Intestinal Morphology in Weaned Kids |
title_full_unstemmed | The Effects of Fucoidan Dietary Supplementation on Growth Performance, Serum Antioxidant Capacity, Immune Function Indices and Intestinal Morphology in Weaned Kids |
title_short | The Effects of Fucoidan Dietary Supplementation on Growth Performance, Serum Antioxidant Capacity, Immune Function Indices and Intestinal Morphology in Weaned Kids |
title_sort | effects of fucoidan dietary supplementation on growth performance, serum antioxidant capacity, immune function indices and intestinal morphology in weaned kids |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8909077/ https://www.ncbi.nlm.nih.gov/pubmed/35268143 http://dx.doi.org/10.3390/ani12050574 |
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