Comprehensive Metabolic Profiling of MYC-Amplified Medulloblastoma Tumors Reveals Key Dependencies on Amino Acid, Tricarboxylic Acid and Hexosamine Pathways

SIMPLE SUMMARY: The oncogene MYC alters cellular metabolism. Medulloblastoma is the most common malignant pediatric brain tumor. MYC-amplified medulloblastoma has a poor prognosis, and the metabolism of MYC-amplified medulloblastoma is poorly understood. We performed comprehensive metabolic profilin...

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Detalles Bibliográficos
Autores principales: Pham, Khoa, Hanaford, Allison R., Poore, Brad A., Maxwell, Micah J., Sweeney, Heather, Parthasarathy, Akhila, Alt, Jesse, Rais, Rana, Slusher, Barbara S., Eberhart, Charles G., Raabe, Eric H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8909278/
https://www.ncbi.nlm.nih.gov/pubmed/35267619
http://dx.doi.org/10.3390/cancers14051311

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8909278/
https://www.ncbi.nlm.nih.gov/pubmed/35267619
http://dx.doi.org/10.3390/cancers14051311

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