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Projecting Lifetime Health Outcomes and Costs Associated with the Ambient Fine Particulate Matter Exposure among Adult Women in Korea

We sought to estimate the lifetime healthcare costs and outcomes associated with the exposure to the escalated concentration of fine particulate matter (particle size < 2.5 μm, PM(2.5)) among adult Korean women. We adapted a previously developed Markov model, and a hypothetical cohort composed of...

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Autores principales: Choi, Gyeyoung, Kim, Yujeong, Shin, Gyeongseon, Bae, SeungJin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8909340/
https://www.ncbi.nlm.nih.gov/pubmed/35270187
http://dx.doi.org/10.3390/ijerph19052494
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author Choi, Gyeyoung
Kim, Yujeong
Shin, Gyeongseon
Bae, SeungJin
author_facet Choi, Gyeyoung
Kim, Yujeong
Shin, Gyeongseon
Bae, SeungJin
author_sort Choi, Gyeyoung
collection PubMed
description We sought to estimate the lifetime healthcare costs and outcomes associated with the exposure to the escalated concentration of fine particulate matter (particle size < 2.5 μm, PM(2.5)) among adult Korean women. We adapted a previously developed Markov model, and a hypothetical cohort composed of Korean women was exposed to either a standard (15 μg/m(3)) or increased (25 μg/m(3)) concentration of PM(2.5). The time horizon of the analysis was 60 years, and the cycle length was 1 year. The outcomes were presented as direct healthcare costs and quality-adjusted life years (QALYs), and costs were discounted annually at 5%. Deterministic and probabilistic sensitivity analyses were performed. The model estimated that when the exposure concentration was increased by 10 μg/m(3), the lifetime healthcare cost increased by USD 9309, which is an 11.3% increase compared to the standard concentration group. Women exposed to a higher concentration of PM(2.5) were predicted to live 30.64 QALYs, compared to 32.08 QALYs for women who were exposed to the standard concentration of PM(2.5). The tendency of a higher cost and shorter QALYs at increased exposure was consistent across a broad range of sensitivity analyses. The negative impact of PM(2.5) was higher on cost than on QALYs and accelerated as the exposure time increased, emphasizing the importance of early intervention.
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spelling pubmed-89093402022-03-11 Projecting Lifetime Health Outcomes and Costs Associated with the Ambient Fine Particulate Matter Exposure among Adult Women in Korea Choi, Gyeyoung Kim, Yujeong Shin, Gyeongseon Bae, SeungJin Int J Environ Res Public Health Article We sought to estimate the lifetime healthcare costs and outcomes associated with the exposure to the escalated concentration of fine particulate matter (particle size < 2.5 μm, PM(2.5)) among adult Korean women. We adapted a previously developed Markov model, and a hypothetical cohort composed of Korean women was exposed to either a standard (15 μg/m(3)) or increased (25 μg/m(3)) concentration of PM(2.5). The time horizon of the analysis was 60 years, and the cycle length was 1 year. The outcomes were presented as direct healthcare costs and quality-adjusted life years (QALYs), and costs were discounted annually at 5%. Deterministic and probabilistic sensitivity analyses were performed. The model estimated that when the exposure concentration was increased by 10 μg/m(3), the lifetime healthcare cost increased by USD 9309, which is an 11.3% increase compared to the standard concentration group. Women exposed to a higher concentration of PM(2.5) were predicted to live 30.64 QALYs, compared to 32.08 QALYs for women who were exposed to the standard concentration of PM(2.5). The tendency of a higher cost and shorter QALYs at increased exposure was consistent across a broad range of sensitivity analyses. The negative impact of PM(2.5) was higher on cost than on QALYs and accelerated as the exposure time increased, emphasizing the importance of early intervention. MDPI 2022-02-22 /pmc/articles/PMC8909340/ /pubmed/35270187 http://dx.doi.org/10.3390/ijerph19052494 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Choi, Gyeyoung
Kim, Yujeong
Shin, Gyeongseon
Bae, SeungJin
Projecting Lifetime Health Outcomes and Costs Associated with the Ambient Fine Particulate Matter Exposure among Adult Women in Korea
title Projecting Lifetime Health Outcomes and Costs Associated with the Ambient Fine Particulate Matter Exposure among Adult Women in Korea
title_full Projecting Lifetime Health Outcomes and Costs Associated with the Ambient Fine Particulate Matter Exposure among Adult Women in Korea
title_fullStr Projecting Lifetime Health Outcomes and Costs Associated with the Ambient Fine Particulate Matter Exposure among Adult Women in Korea
title_full_unstemmed Projecting Lifetime Health Outcomes and Costs Associated with the Ambient Fine Particulate Matter Exposure among Adult Women in Korea
title_short Projecting Lifetime Health Outcomes and Costs Associated with the Ambient Fine Particulate Matter Exposure among Adult Women in Korea
title_sort projecting lifetime health outcomes and costs associated with the ambient fine particulate matter exposure among adult women in korea
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8909340/
https://www.ncbi.nlm.nih.gov/pubmed/35270187
http://dx.doi.org/10.3390/ijerph19052494
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