Precision Oncology in Lower-Grade Gliomas: Promises and Pitfalls of Therapeutic Strategies Targeting IDH-Mutations

SIMPLE SUMMARY: Mutations of isocitrate dehydrogenase (IDH) genes are the distinctive genetic feature of lower-grade gliomas (LGGs). Tumor-associated IDH1/2 mutations result in a loss of normal enzymatic function and the abnormal production of 2-hydroxyglutarate (2-HG), which acts as an oncometaboli...

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Detalles Bibliográficos
Autores principales: Persico, Pasquale, Lorenzi, Elena, Losurdo, Agnese, Dipasquale, Angelo, Di Muzio, Antonio, Navarria, Pierina, Pessina, Federico, Politi, Letterio Salvatore, Lombardi, Giuseppe, Santoro, Armando, Simonelli, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8909346/
https://www.ncbi.nlm.nih.gov/pubmed/35267433
http://dx.doi.org/10.3390/cancers14051125

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8909346/
https://www.ncbi.nlm.nih.gov/pubmed/35267433
http://dx.doi.org/10.3390/cancers14051125

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