Cargando…

Precision Oncology in Lower-Grade Gliomas: Promises and Pitfalls of Therapeutic Strategies Targeting IDH-Mutations

SIMPLE SUMMARY: Mutations of isocitrate dehydrogenase (IDH) genes are the distinctive genetic feature of lower-grade gliomas (LGGs). Tumor-associated IDH1/2 mutations result in a loss of normal enzymatic function and the abnormal production of 2-hydroxyglutarate (2-HG), which acts as an oncometaboli...

Descripción completa

Detalles Bibliográficos
Autores principales:	Persico, Pasquale, Lorenzi, Elena, Losurdo, Agnese, Dipasquale, Angelo, Di Muzio, Antonio, Navarria, Pierina, Pessina, Federico, Politi, Letterio Salvatore, Lombardi, Giuseppe, Santoro, Armando, Simonelli, Matteo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8909346/ https://www.ncbi.nlm.nih.gov/pubmed/35267433 http://dx.doi.org/10.3390/cancers14051125

Ejemplares similares

Checkpoint Inhibitors as High-Grade Gliomas Treatment: State of the Art and Future Perspectives
por: Persico, Pasquale, et al.
Publicado: (2021)

Immunotherapeutic early-phase clinical trials and malignant gliomas: A single-center experience and comprehensive immunophenotyping of circulating leukocytes
por: Simonelli, Matteo, et al.
Publicado: (2021)

Conducting Phase I Trials During the SARS-Coronavirus-2 Outbreak: About Science and Care
por: Dipasquale, Angelo, et al.
Publicado: (2020)

COVID-19 lung injury as a primer for immune checkpoint inhibitors (ICIs)-related pneumonia in a patient affected by squamous head and neck carcinoma treated with PD-L1 blockade: a case report
por: Dipasquale, Angelo, et al.
Publicado: (2021)

Role of 11C Methionine Positron Emission Tomography (11CMETPET) for Surgery and Radiation Therapy Planning in Newly Diagnosed Glioblastoma Patients Enrolled into a Phase II Clinical Study
por: Pessina, Federico, et al.
Publicado: (2021)

Preoperative [(11)C]methionine PET to personalize treatment decisions in patients with lower-grade gliomas
por: Ninatti, Gaia, et al.
Publicado: (2022)

Circulating endothelial cells in oncology: pitfalls and promises
por: Strijbos, M H, et al.
Publicado: (2008)

The radiologist empowerment through virtual multidisciplinary tumor boards: The commitment of oncologic care during COVID-19 pandemic
por: Gennaro, Nicolò, et al.
Publicado: (2021)

Definition of the Prognostic Role of MGMT Promoter Methylation Value by Pyrosequencing in Newly Diagnosed IDH Wild-Type Glioblastoma Patients Treated with Radiochemotherapy: A Large Multicenter Study
por: Caccese, Mario, et al.
Publicado: (2022)

Integrating next-generation sequencing into clinical oncology: strategies, promises and pitfalls
por: Horak, Peter, et al.
Publicado: (2016)

Liquid Biopsy of Cerebrospinal Fluid Enables Selective Profiling of Glioma Molecular Subtypes at First Clinical Presentation
por: Orzan, Francesca, et al.
Publicado: (2023)

Promise and pitfalls of the Immunochip
por: Cortes, Adrian, et al.
Publicado: (2011)

The Promise and Pitfalls of Prophages
por: McKerral, Jody C., et al.
Publicado: (2023)

Editorial: Novel diagnostic and therapeutic strategies in the management of cerebral gliomas, Volume II
por: Bosio, Alberto, et al.
Publicado: (2023)

DNA Barcoding: Promise and Pitfalls
por: Moritz, Craig, et al.
Publicado: (2004)

Personalized Medicine: Promises and Pitfalls
por: Huang, Jean
Publicado: (2017)

Multimodality therapy approaches, local and systemic treatment, compared with chemotherapy alone in recurrent glioblastoma
por: Scorsetti, Marta, et al.
Publicado: (2015)

Pitfalls in paediatric oncology imaging
por: Wessely, K., et al.
Publicado: (2011)

Promise and Pitfalls of Animal Models of Schizophrenia
por: Feifel, David, et al.
Publicado: (2010)

Promises and Pitfalls of Intracellular Delivery of Proteins
por: Fu, Ailing, et al.
Publicado: (2014)

Nuclear worker studies: promise and pitfalls
por: Wakeford, R
Publicado: (2014)

The Genetics of Sepsis: The Promise, the Progress and the Pitfalls
por: Waterer, Grant W.
Publicado: (2008)

Dissociation and Brain Rhythms: Pitfalls and Promises
por: Grent-'t-Jong, Tineke, et al.
Publicado: (2021)

The promise and pitfalls of cross-partisan conversations for reducing affective polarization: Evidence from randomized experiments
por: Santoro, Erik, et al.
Publicado: (2022)

Potential and Pitfalls of Pharmacovigilance Databases in Oncology
por: Schlam, Ilana, et al.
Publicado: (2023)

Artificial intelligence in oncology: chances and pitfalls
por: Kather, Jakob Nikolas
Publicado: (2023)

Are three weeks hypofractionated radiation therapy (HFRT) comparable to six weeks for newly diagnosed glioblastoma patients? Results of a phase II study
por: Navarria, Pierina, et al.
Publicado: (2017)

Neutrophils in Gliomas
por: Massara, Matteo, et al.
Publicado: (2017)

Mass spectrometry-based assay for the molecular diagnosis of glioma: concomitant detection of chromosome 1p/19q codeletion, and IDH1, IDH2, and TERT mutation status
por: Pesenti, Chiara, et al.
Publicado: (2017)

Laparoscopy for Penetrating Thoracoabdominal Trauma: Pitfalls and Promises
por: Guth, Amber A., et al.
Publicado: (1998)

The promise and pitfalls of the internet for cognitive behavioral therapy
por: Andersson, Gerhard
Publicado: (2010)

Promise and pitfalls of molecular markers of thyroid nodules
por: Jadhav, S., et al.
Publicado: (2012)

Computational neuroscience across the lifespan: Promises and pitfalls
por: van den Bos, Wouter, et al.
Publicado: (2017)

The promise – and pitfalls – of smoke-free policy adoption
por: Rees, Vaughan W.
Publicado: (2019)

Promises and pitfalls of electronic health record analysis
por: Farmer, Ruth, et al.
Publicado: (2017)

Telemedicine in post–CABG patients: promises and pitfalls
por: Hofstra, L., et al.
Publicado: (2021)

Editorial: Pharmacotherapy of Anxiety Disorders: Promises and Pitfalls
por: Garakani, Amir, et al.
Publicado: (2021)

Tele-health in pediatric ophthalmology: Promises and pitfalls
por: Chakrabarti, Rahul, et al.
Publicado: (2021)

Lung cancer immunotherapy: progress, pitfalls, and promises
por: Lahiri, Aritraa, et al.
Publicado: (2023)

Locally led adaptation: Promise, pitfalls, and possibilities
por: Rahman, M. Feisal, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_l1l6iltabk7613003m3e9n4do0