Cargando…
Androgen Receptor-Mediated Transcription in Prostate Cancer
Androgen receptor (AR)-mediated transcription is critical in almost all stages of prostate cancer (PCa) growth and differentiation. This process involves a complex interplay of coregulatory proteins, chromatin remodeling complexes, and other transcription factors that work with AR at cis-regulatory...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8909478/ https://www.ncbi.nlm.nih.gov/pubmed/35269520 http://dx.doi.org/10.3390/cells11050898 |
_version_ | 1784666163117031424 |
---|---|
author | Özturan, Doğancan Morova, Tunç Lack, Nathan A. |
author_facet | Özturan, Doğancan Morova, Tunç Lack, Nathan A. |
author_sort | Özturan, Doğancan |
collection | PubMed |
description | Androgen receptor (AR)-mediated transcription is critical in almost all stages of prostate cancer (PCa) growth and differentiation. This process involves a complex interplay of coregulatory proteins, chromatin remodeling complexes, and other transcription factors that work with AR at cis-regulatory enhancer regions to induce the spatiotemporal transcription of target genes. This enhancer-driven mechanism is remarkably dynamic and undergoes significant alterations during PCa progression. In this review, we discuss the AR mechanism of action in PCa with a focus on how cis-regulatory elements modulate gene expression. We explore emerging evidence of genetic variants that can impact AR regulatory regions and alter gene transcription in PCa. Finally, we highlight several outstanding questions and discuss potential mechanisms of this critical transcription factor. |
format | Online Article Text |
id | pubmed-8909478 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89094782022-03-11 Androgen Receptor-Mediated Transcription in Prostate Cancer Özturan, Doğancan Morova, Tunç Lack, Nathan A. Cells Review Androgen receptor (AR)-mediated transcription is critical in almost all stages of prostate cancer (PCa) growth and differentiation. This process involves a complex interplay of coregulatory proteins, chromatin remodeling complexes, and other transcription factors that work with AR at cis-regulatory enhancer regions to induce the spatiotemporal transcription of target genes. This enhancer-driven mechanism is remarkably dynamic and undergoes significant alterations during PCa progression. In this review, we discuss the AR mechanism of action in PCa with a focus on how cis-regulatory elements modulate gene expression. We explore emerging evidence of genetic variants that can impact AR regulatory regions and alter gene transcription in PCa. Finally, we highlight several outstanding questions and discuss potential mechanisms of this critical transcription factor. MDPI 2022-03-05 /pmc/articles/PMC8909478/ /pubmed/35269520 http://dx.doi.org/10.3390/cells11050898 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Özturan, Doğancan Morova, Tunç Lack, Nathan A. Androgen Receptor-Mediated Transcription in Prostate Cancer |
title | Androgen Receptor-Mediated Transcription in Prostate Cancer |
title_full | Androgen Receptor-Mediated Transcription in Prostate Cancer |
title_fullStr | Androgen Receptor-Mediated Transcription in Prostate Cancer |
title_full_unstemmed | Androgen Receptor-Mediated Transcription in Prostate Cancer |
title_short | Androgen Receptor-Mediated Transcription in Prostate Cancer |
title_sort | androgen receptor-mediated transcription in prostate cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8909478/ https://www.ncbi.nlm.nih.gov/pubmed/35269520 http://dx.doi.org/10.3390/cells11050898 |
work_keys_str_mv | AT ozturandogancan androgenreceptormediatedtranscriptioninprostatecancer AT morovatunc androgenreceptormediatedtranscriptioninprostatecancer AT lacknathana androgenreceptormediatedtranscriptioninprostatecancer |