Cargando…

Androgen Receptor-Mediated Transcription in Prostate Cancer

Androgen receptor (AR)-mediated transcription is critical in almost all stages of prostate cancer (PCa) growth and differentiation. This process involves a complex interplay of coregulatory proteins, chromatin remodeling complexes, and other transcription factors that work with AR at cis-regulatory...

Descripción completa

Detalles Bibliográficos
Autores principales: Özturan, Doğancan, Morova, Tunç, Lack, Nathan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8909478/
https://www.ncbi.nlm.nih.gov/pubmed/35269520
http://dx.doi.org/10.3390/cells11050898
_version_ 1784666163117031424
author Özturan, Doğancan
Morova, Tunç
Lack, Nathan A.
author_facet Özturan, Doğancan
Morova, Tunç
Lack, Nathan A.
author_sort Özturan, Doğancan
collection PubMed
description Androgen receptor (AR)-mediated transcription is critical in almost all stages of prostate cancer (PCa) growth and differentiation. This process involves a complex interplay of coregulatory proteins, chromatin remodeling complexes, and other transcription factors that work with AR at cis-regulatory enhancer regions to induce the spatiotemporal transcription of target genes. This enhancer-driven mechanism is remarkably dynamic and undergoes significant alterations during PCa progression. In this review, we discuss the AR mechanism of action in PCa with a focus on how cis-regulatory elements modulate gene expression. We explore emerging evidence of genetic variants that can impact AR regulatory regions and alter gene transcription in PCa. Finally, we highlight several outstanding questions and discuss potential mechanisms of this critical transcription factor.
format Online
Article
Text
id pubmed-8909478
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-89094782022-03-11 Androgen Receptor-Mediated Transcription in Prostate Cancer Özturan, Doğancan Morova, Tunç Lack, Nathan A. Cells Review Androgen receptor (AR)-mediated transcription is critical in almost all stages of prostate cancer (PCa) growth and differentiation. This process involves a complex interplay of coregulatory proteins, chromatin remodeling complexes, and other transcription factors that work with AR at cis-regulatory enhancer regions to induce the spatiotemporal transcription of target genes. This enhancer-driven mechanism is remarkably dynamic and undergoes significant alterations during PCa progression. In this review, we discuss the AR mechanism of action in PCa with a focus on how cis-regulatory elements modulate gene expression. We explore emerging evidence of genetic variants that can impact AR regulatory regions and alter gene transcription in PCa. Finally, we highlight several outstanding questions and discuss potential mechanisms of this critical transcription factor. MDPI 2022-03-05 /pmc/articles/PMC8909478/ /pubmed/35269520 http://dx.doi.org/10.3390/cells11050898 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Özturan, Doğancan
Morova, Tunç
Lack, Nathan A.
Androgen Receptor-Mediated Transcription in Prostate Cancer
title Androgen Receptor-Mediated Transcription in Prostate Cancer
title_full Androgen Receptor-Mediated Transcription in Prostate Cancer
title_fullStr Androgen Receptor-Mediated Transcription in Prostate Cancer
title_full_unstemmed Androgen Receptor-Mediated Transcription in Prostate Cancer
title_short Androgen Receptor-Mediated Transcription in Prostate Cancer
title_sort androgen receptor-mediated transcription in prostate cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8909478/
https://www.ncbi.nlm.nih.gov/pubmed/35269520
http://dx.doi.org/10.3390/cells11050898
work_keys_str_mv AT ozturandogancan androgenreceptormediatedtranscriptioninprostatecancer
AT morovatunc androgenreceptormediatedtranscriptioninprostatecancer
AT lacknathana androgenreceptormediatedtranscriptioninprostatecancer