Bile Acids: Key Players in Inflammatory Bowel Diseases?

Inflammatory bowel diseases (IBDs) have emerged as a public health problem worldwide with a limited number of efficient therapeutic options despite advances in medical therapy. Although changes in the gut microbiota composition are recognized as key drivers of dysregulated intestinal immunity, alter...

Descripción completa

Detalles Bibliográficos
Autores principales: Kriaa, Aicha, Mariaule, Vincent, Jablaoui, Amin, Rhimi, Soufien, Mkaouar, Hela, Hernandez, Juan, Korkmaz, Brice, Lesner, Adam, Maguin, Emmanuelle, Aghdassi, Ali, Rhimi, Moez
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8909766/
https://www.ncbi.nlm.nih.gov/pubmed/35269523
http://dx.doi.org/10.3390/cells11050901
Descripción
Sumario:Inflammatory bowel diseases (IBDs) have emerged as a public health problem worldwide with a limited number of efficient therapeutic options despite advances in medical therapy. Although changes in the gut microbiota composition are recognized as key drivers of dysregulated intestinal immunity, alterations in bile acids (BAs) have been shown to influence gut homeostasis and contribute to the pathogenesis of the disease. In this review, we explore the interactions involving BAs and gut microbiota in IBDs, and discuss how the gut microbiota–BA–host axis may influence digestive inflammation.

Ejemplares similares