Assessing Tumour Haemodynamic Heterogeneity and Response to Choline Kinase Inhibition Using Clustered Dynamic Contrast Enhanced MRI Parameters in Rodent Models of Glioblastoma

SIMPLE SUMMARY: This study was designed to monitor changes in DCE-MRI-based parameters in preclinical GBM models in response to choline kinase inhibition using a cluster analysis approach. In terms of therapeutic response in F98 rat GBMs, a sustained decrease in permeability and perfusion and increa...

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Detalles Bibliográficos
Autores principales: Bhaduri, Sourav, Lesbats, Clémentine, Sharkey, Jack, Kelly, Claire Louise, Mukherjee, Soham, Taylor, Arthur, Delikatny, Edward J., Kim, Sungheon G., Poptani, Harish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8909848/
https://www.ncbi.nlm.nih.gov/pubmed/35267531
http://dx.doi.org/10.3390/cancers14051223

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