Monthly Dynamics of Plasma Elements, Hematology, Oxidative Stress Markers, and Hormonal Concentrations in Growing Male Shiba Goats (Capra hircus) Reared in Tokyo-Japan

SIMPLE SUMMARY: During the first stage of an animal’s life, various physiological alterations with the concomitant development of different body organs occur. This period is also accompanied by different kinds of stressors, including, but not limited to, the stress of weaning, metabolic change, and peri-puberty changes in reproductive functions. Shiba goats, the main goat breed in Japan, are not commonly used as food animals. However, male Shiba goats largely contribute to reproductive and cardiology research activities, as well as being used for educational purposes for elementary school children. The physiological data regarding laboratory measurements in Shiba goats are lacking, especially at a young age. In this study, we investigated the age-related changes in hematology, plasma mineral concentrations, hormones, and oxidative stress markers during the first five months (neonatal and peri-puberty age) in male Shiba goats. ABSTRACT: From a clinical point of view, the establishment of laboratory variables during the first few months of an animal’s life helps clinicians to make sure they base their medical decisions on laboratory values for the specific breed and age group. The present study aimed to investigate the monthly dynamics in some plasma elements, hematology, reproductive hormones, and oxidative stress marker profiles during the first five months of age (neonatal and peri-puberty stage) in male Shiba goat’s kids. Sixteen kids were investigated from the first to the fifth month (M1 to M5), and the data were presented as the statistical difference between them. Whole blood and plasma samples were collected monthly for analysis of basal hematology, plasma elements concentration (trace elements: Cu, Zn, Se, Fe, and Cr; macroelements: Ca and Mg), circulating hormones (cortisol, FSH, LH, IGF1, immunoreactive inhibin, testosterone, T3, and T4), and oxidative stress markers (MDA, CAT, SOD, and GPX). The results showed age-related changes in the observed parameters. The fifth month recorded the lowest level of almost all investigated minerals, except for Cr. Plasma hormone levels revealed age-dependent increases in IGF-1 and testosterone, age-related decreases in T3 and T4, and non-significant changes in cortisol and FSH. Besides, the concentrations of inhibin and LH were significantly higher at M1–M3 compared with M4–M5. Plasma SOD, GPX, and CAT were increased with age. In conclusion, age-related changes and a distinction of age in months was found necessary to interpret the laboratory results, specifically in terms of age in months and the peri-puberty stage in young goats, which are important to follow up the age-specific diseases, reproductive status, and treatment follow-ups in this stage.