Cargando…

Cancer-Associated Fibroblasts: Mechanisms of Tumor Progression and Novel Therapeutic Targets

SIMPLE SUMMARY: The tumor microenvironment plays an important role in determining the biological behavior of several of the more aggressive malignancies. Among the various cell types evident in the tumor “field”, cancer-associated fibroblasts (CAFs) are a heterogenous collection of activated fibrobl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Czekay, Ralf-Peter, Cheon, Dong-Joo, Samarakoon, Rohan, Kutz, Stacie M., Higgins, Paul J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8909913/ https://www.ncbi.nlm.nih.gov/pubmed/35267539 http://dx.doi.org/10.3390/cancers14051231

Ejemplares similares

Downstream Targets of VHL/HIF-α Signaling in Renal Clear Cell Carcinoma Progression: Mechanisms and Therapeutic Relevance
por: Mazumder, Sonia, et al.
Publicado: (2023)

PAI-1: An Integrator of Cell Signaling and Migration
por: Czekay, Ralf-Peter, et al.
Publicado: (2011)

Deregulation of Negative Controls on TGF-β1 Signaling in Tumor Progression
por: Tang, Jiaqi, et al.
Publicado: (2018)

Heat Shock Protein 27, a Novel Downstream Target of Collagen Type XI alpha 1, Synergizes with Fatty Acid Oxidation to Confer Cisplatin Resistance in Ovarian Cancer Cells
por: Heiserman, James Patrick, et al.
Publicado: (2021)

Mineralocorticoid Receptor-Associated Mechanisms in Diabetic Kidney Disease and Clinical Significance of Mineralocorticoid Receptor Antagonists
por: Mende, Christian W., et al.
Publicado: (2023)

TGF-β1-Induced Expression of the Poor Prognosis SERPINE1/PAI-1 Gene Requires EGFR Signaling: A New Target for Anti-EGFR Therapy
por: Samarakoon, Rohan, et al.
Publicado: (2009)

Editorial: Premature Aging and Senescence in Renal Fibrosis
por: Samarakoon, Rohan, et al.
Publicado: (2021)

The TGF-β1/p53/PAI-1 Signaling Axis in Vascular Senescence: Role of Caveolin-1
por: Samarakoon, Rohan, et al.
Publicado: (2019)

Activated Fibroblast Program Orchestrates Tumor Initiation and Progression; Molecular Mechanisms and the Associated Therapeutic Strategies
por: Yoshida, Go J., et al.
Publicado: (2019)

Natural Compounds Targeting Cancer-Associated Fibroblasts against Digestive System Tumor Progression: Therapeutic Insights
por: Chiu, Kuan-Jung, et al.
Publicado: (2022)

Redox-Induced Src Kinase and Caveolin-1 Signaling in TGF-β1-Initiated SMAD2/3 Activation and PAI-1 Expression
por: Samarakoon, Rohan, et al.
Publicado: (2011)

The Genomic Response to TGF-β1 Dictates Failed Repair and Progression of Fibrotic Disease in the Obstructed Kidney
por: Higgins, Craig E., et al.
Publicado: (2021)

Tumor Progression from a Fibroblast Activation Protein Perspective: Novel Diagnostic and Therapeutic Scenarios for Colorectal Cancer
por: Rossetti, Martina, et al.
Publicado: (2023)

Fibroblast Growth Factor Receptors as Novel Therapeutic Targets in SNF5-Deleted Malignant Rhabdoid Tumors
por: Wöhrle, Simon, et al.
Publicado: (2013)

Targeting the SLIT/ROBO pathway in tumor progression: molecular mechanisms and therapeutic perspectives
por: Jiang, Zhengdong, et al.
Publicado: (2019)

Research Progress on Therapeutic Targeting of Cancer-Associated Fibroblasts to Tackle Treatment-Resistant NSCLC
por: Li, Chenxin, et al.
Publicado: (2022)

Plasminogen activator inhibitor-1 detaches cells from extracellular matrices by inactivating integrins
por: Czekay, Ralf-Peter, et al.
Publicado: (2003)

CBMS-04 Novel xenograft model to clarify tumor progressive mechanism and therapeutic target in primary central nervous system lymphoma
por: Tateishi, Kensuke, et al.
Publicado: (2020)

Cellular and Molecular Mechanisms of the Tumor Stroma in Colorectal Cancer: Insights into Disease Progression and Therapeutic Targets
por: Shakhpazyan, Nikolay, et al.
Publicado: (2023)

H/ACA Small Ribonucleoproteins: Structural and Functional Comparison Between Archaea and Eukaryotes
por: Czekay, Dominic P., et al.
Publicado: (2021)

Cancer-associated fibroblast regulation of tumor neo-angiogenesis as a therapeutic target in cancer
por: Wang, Fang-Tao, et al.
Publicado: (2019)

The Role of Cancer-Associated Fibroblasts in Tumor Progression
por: Joshi, Rushikesh S., et al.
Publicado: (2021)

Cancer-associated fibroblasts and their role in tumor progression
por: Ermakov, M.S., et al.
Publicado: (2022)

Targeting Macrophage-Recruiting Chemokines as a Novel Therapeutic Strategy to Prevent the Progression of Solid Tumors
por: Argyle, David, et al.
Publicado: (2018)

Therapeutic Targeting of CDK7 Suppresses Tumor Progression in Intrahepatic Cholangiocarcinoma
por: Chen, Hua-Dong, et al.
Publicado: (2020)

Fibroblast activation protein-α expression in fibroblasts is common in the tumor microenvironment of colorectal cancer and may serve as a therapeutic target
por: Greimelmaier, K., et al.
Publicado: (2023)

Stromal Fibroblast in Age-Related Cancer: Role in Tumorigenesis and Potential as Novel Therapeutic Target
por: Elkhattouti, Abdelouahid, et al.
Publicado: (2015)

Tumor Progression Locus 2 (Tpl2) Kinase as a Novel Therapeutic Target for Cancer: Double-Sided Effects of Tpl2 on Cancer
por: Lee, Hye Won, et al.
Publicado: (2015)

Role of cancer-associated fibroblasts in the progression, therapeutic resistance and targeted therapy of oesophageal squamous cell carcinoma
por: Xue, Mengying, et al.
Publicado: (2023)

Novel Therapeutic Targets in the Brain Tumor Microenvironment
por: Phillips, Joanna J.
Publicado: (2012)

Novel Therapeutic Targets for Tumor Microenvironment in Cancer
por: Bei, Roberto, et al.
Publicado: (2023)

The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis
por: Huang, Yuhe, et al.
Publicado: (2022)

Therapeutic Targeting of Cancer-Associated Fibroblasts in the Non-Small Cell Lung Cancer Tumor Microenvironment
por: Shintani, Yasushi, et al.
Publicado: (2023)

Fibroblast Growth Factor Receptor 4 Targeting in Cancer: New Insights into Mechanisms and Therapeutic Strategies †
por: Lang, Liwei, et al.
Publicado: (2019)

Fibroblast growth factor receptors in cancer: genetic alterations, diagnostics, therapeutic targets and mechanisms of resistance
por: Krook, Melanie A., et al.
Publicado: (2020)

SERPINE1 associated with remodeling of the tumor microenvironment in colon cancer progression: a novel therapeutic target
por: Wang, Shaokun, et al.
Publicado: (2021)

A Novel Prognostic Marker and Therapeutic Target Associated with Glioma Progression in a Tumor Immune Microenvironment
por: Zhang, Jun-Jie, et al.
Publicado: (2023)

PAI-1 Regulates the Invasive Phenotype in Human Cutaneous Squamous Cell Carcinoma
por: Freytag, Jennifer, et al.
Publicado: (2009)

The Dual-Role of Methylglyoxal in Tumor Progression – Novel Therapeutic Approaches
por: Leone, Alessia, et al.
Publicado: (2021)

Carcinoma-Associated Fibroblasts Are a Promising Therapeutic Target
por: Togo, Shinsaku, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_ajfjcdjq0loq2skja98o4p3547