Cargando…

The Risk of Herpes Zoster in Women with Polycystic Ovary Syndrome: A Retrospective Population-Based Study

Background: The association between polycystic ovary syndrome (PCOS) and the risk of herpes zoster (HZ) remains unclear. This study investigated the risk of HZ in women with PCOS. Methods: This study used data from the Longitudinal Generation Tracking Database (LGTD 2005) which contains the informat...

Descripción completa

Detalles Bibliográficos
Autores principales: Hsieh, Wen-Che, Chen, Chia-Hung, Cheng, Yung-Chi, Yu, Teng-Shun, Hsu, Chung Y., Ke, Der-Shin, Lin, Chih-Ming, Hsu, Chao-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8909925/
https://www.ncbi.nlm.nih.gov/pubmed/35270787
http://dx.doi.org/10.3390/ijerph19053094
_version_ 1784666312864169984
author Hsieh, Wen-Che
Chen, Chia-Hung
Cheng, Yung-Chi
Yu, Teng-Shun
Hsu, Chung Y.
Ke, Der-Shin
Lin, Chih-Ming
Hsu, Chao-Yu
author_facet Hsieh, Wen-Che
Chen, Chia-Hung
Cheng, Yung-Chi
Yu, Teng-Shun
Hsu, Chung Y.
Ke, Der-Shin
Lin, Chih-Ming
Hsu, Chao-Yu
author_sort Hsieh, Wen-Che
collection PubMed
description Background: The association between polycystic ovary syndrome (PCOS) and the risk of herpes zoster (HZ) remains unclear. This study investigated the risk of HZ in women with PCOS. Methods: This study used data from the Longitudinal Generation Tracking Database (LGTD 2005) which contains the information of 2 million randomly selected from National Health Insurance beneficiaries. Patients who received a diagnosis of PCOS between 2000 and 2017 were included in the PCOS cohort. Patients who were not diagnosed as having PCOS were randomly selected from the LGTD 2005 and included in the control cohort. Patients who were aged <20 years and had a history of HZ before the index date were excluded. Patients who were in both the cohorts were matched at a ratio of 1:1 through propensity score matching based on age, comorbidities, and medication. The primary outcome was the diagnosis of HZ. Results: A total of 20,142 patients were included in each case and control cohorts. The incidence rates of HZ in the PCOS and control cohorts were 3.92 and 3.17 per 1000 person-years, respectively. The PCOS cohort had a significantly higher risk of HZ than did the control cohort (adjusted hazard ratios [aHR] = 1.26). Among the patients aged 30–39 years, those with PCOS had a significantly higher risk of HZ than did those without PCOS (aHR = 1.31). Among the patients without any comorbidities, those with PCOS had a significantly higher risk of HZ (aHR = 1.26) than did those without PCOS. Conclusion: PCOS is associated with the risk of HZ, especially in young women. The risk of HZ should be addressed while treating patients with PCOS. An HZ vaccine is recommended for these patients.
format Online
Article
Text
id pubmed-8909925
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-89099252022-03-11 The Risk of Herpes Zoster in Women with Polycystic Ovary Syndrome: A Retrospective Population-Based Study Hsieh, Wen-Che Chen, Chia-Hung Cheng, Yung-Chi Yu, Teng-Shun Hsu, Chung Y. Ke, Der-Shin Lin, Chih-Ming Hsu, Chao-Yu Int J Environ Res Public Health Article Background: The association between polycystic ovary syndrome (PCOS) and the risk of herpes zoster (HZ) remains unclear. This study investigated the risk of HZ in women with PCOS. Methods: This study used data from the Longitudinal Generation Tracking Database (LGTD 2005) which contains the information of 2 million randomly selected from National Health Insurance beneficiaries. Patients who received a diagnosis of PCOS between 2000 and 2017 were included in the PCOS cohort. Patients who were not diagnosed as having PCOS were randomly selected from the LGTD 2005 and included in the control cohort. Patients who were aged <20 years and had a history of HZ before the index date were excluded. Patients who were in both the cohorts were matched at a ratio of 1:1 through propensity score matching based on age, comorbidities, and medication. The primary outcome was the diagnosis of HZ. Results: A total of 20,142 patients were included in each case and control cohorts. The incidence rates of HZ in the PCOS and control cohorts were 3.92 and 3.17 per 1000 person-years, respectively. The PCOS cohort had a significantly higher risk of HZ than did the control cohort (adjusted hazard ratios [aHR] = 1.26). Among the patients aged 30–39 years, those with PCOS had a significantly higher risk of HZ than did those without PCOS (aHR = 1.31). Among the patients without any comorbidities, those with PCOS had a significantly higher risk of HZ (aHR = 1.26) than did those without PCOS. Conclusion: PCOS is associated with the risk of HZ, especially in young women. The risk of HZ should be addressed while treating patients with PCOS. An HZ vaccine is recommended for these patients. MDPI 2022-03-06 /pmc/articles/PMC8909925/ /pubmed/35270787 http://dx.doi.org/10.3390/ijerph19053094 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hsieh, Wen-Che
Chen, Chia-Hung
Cheng, Yung-Chi
Yu, Teng-Shun
Hsu, Chung Y.
Ke, Der-Shin
Lin, Chih-Ming
Hsu, Chao-Yu
The Risk of Herpes Zoster in Women with Polycystic Ovary Syndrome: A Retrospective Population-Based Study
title The Risk of Herpes Zoster in Women with Polycystic Ovary Syndrome: A Retrospective Population-Based Study
title_full The Risk of Herpes Zoster in Women with Polycystic Ovary Syndrome: A Retrospective Population-Based Study
title_fullStr The Risk of Herpes Zoster in Women with Polycystic Ovary Syndrome: A Retrospective Population-Based Study
title_full_unstemmed The Risk of Herpes Zoster in Women with Polycystic Ovary Syndrome: A Retrospective Population-Based Study
title_short The Risk of Herpes Zoster in Women with Polycystic Ovary Syndrome: A Retrospective Population-Based Study
title_sort risk of herpes zoster in women with polycystic ovary syndrome: a retrospective population-based study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8909925/
https://www.ncbi.nlm.nih.gov/pubmed/35270787
http://dx.doi.org/10.3390/ijerph19053094
work_keys_str_mv AT hsiehwenche theriskofherpeszosterinwomenwithpolycysticovarysyndromearetrospectivepopulationbasedstudy
AT chenchiahung theriskofherpeszosterinwomenwithpolycysticovarysyndromearetrospectivepopulationbasedstudy
AT chengyungchi theriskofherpeszosterinwomenwithpolycysticovarysyndromearetrospectivepopulationbasedstudy
AT yutengshun theriskofherpeszosterinwomenwithpolycysticovarysyndromearetrospectivepopulationbasedstudy
AT hsuchungy theriskofherpeszosterinwomenwithpolycysticovarysyndromearetrospectivepopulationbasedstudy
AT kedershin theriskofherpeszosterinwomenwithpolycysticovarysyndromearetrospectivepopulationbasedstudy
AT linchihming theriskofherpeszosterinwomenwithpolycysticovarysyndromearetrospectivepopulationbasedstudy
AT hsuchaoyu theriskofherpeszosterinwomenwithpolycysticovarysyndromearetrospectivepopulationbasedstudy
AT hsiehwenche riskofherpeszosterinwomenwithpolycysticovarysyndromearetrospectivepopulationbasedstudy
AT chenchiahung riskofherpeszosterinwomenwithpolycysticovarysyndromearetrospectivepopulationbasedstudy
AT chengyungchi riskofherpeszosterinwomenwithpolycysticovarysyndromearetrospectivepopulationbasedstudy
AT yutengshun riskofherpeszosterinwomenwithpolycysticovarysyndromearetrospectivepopulationbasedstudy
AT hsuchungy riskofherpeszosterinwomenwithpolycysticovarysyndromearetrospectivepopulationbasedstudy
AT kedershin riskofherpeszosterinwomenwithpolycysticovarysyndromearetrospectivepopulationbasedstudy
AT linchihming riskofherpeszosterinwomenwithpolycysticovarysyndromearetrospectivepopulationbasedstudy
AT hsuchaoyu riskofherpeszosterinwomenwithpolycysticovarysyndromearetrospectivepopulationbasedstudy