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Understanding the Molecular Mechanisms of Succinic Semialdehyde Dehydrogenase Deficiency (SSADHD): Towards the Development of SSADH-Targeted Medicine

Succinic semialdehyde dehydrogenase deficiency (SSADHD) is a rare genetic disorder caused by inefficient metabolic breakdown of the major inhibitory neurotransmitter, γ-aminobutyric acid (GABA). Pathologic brain accumulation of GABA and γ-hydroxybutyrate (GHB), a neuroactive by-product of GABA catab...

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Detalles Bibliográficos
Autores principales:	Lee, Henry H. C., McGinty, Gabrielle E., Pearl, Phillip L., Rotenberg, Alexander
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910003/ https://www.ncbi.nlm.nih.gov/pubmed/35269750 http://dx.doi.org/10.3390/ijms23052606

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