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Choosing between Homologous or Heterologous COVID-19 Vaccination Regimens: A Cross-Sectional Study among the General Population in Italy
A shortage of COVID-19 vaccines and reports of side-effects led several countries to recommend a heterologous regimen for second vaccine doses. This study aimed to describe the reasons behind individuals’ choices of a homologous or a heterologous second vaccination. This cross-sectional study enroll...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910024/ https://www.ncbi.nlm.nih.gov/pubmed/35270636 http://dx.doi.org/10.3390/ijerph19052944 |
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author | Clari, Marco Godono, Alessandro Albanesi, Beatrice Casabona, Elena Comoretto, Rosanna Irene Mansour, Ihab Conti, Alessio Dimonte, Valerio Ciocan, Catalina |
author_facet | Clari, Marco Godono, Alessandro Albanesi, Beatrice Casabona, Elena Comoretto, Rosanna Irene Mansour, Ihab Conti, Alessio Dimonte, Valerio Ciocan, Catalina |
author_sort | Clari, Marco |
collection | PubMed |
description | A shortage of COVID-19 vaccines and reports of side-effects led several countries to recommend a heterologous regimen for second vaccine doses. This study aimed to describe the reasons behind individuals’ choices of a homologous or a heterologous second vaccination. This cross-sectional study enrolled individuals under 60 who had received a first dose of Vaxzevria and could choose between a homologous or heterologous regimen for their second dose. Quantitative (socio-demographic, clinical characteristics) and qualitative data were collected and analysed through a generalized linear model and thematic analysis, respectively. Of the 1437 individuals included in the analysis, the majority (76.1%) chose a heterologous second dose of the COVID-19 vaccination. More females chose a heterologous vaccination regimen (p = 0.003). Younger individuals also tended to choose heterologous vaccination (p < 0.001). The main motivation in favour of heterologous vaccination was to follow the Italian Ministry of Health recommendations (n = 118; 53.9%). This study showed that most individuals, mainly younger people and females, chose a heterologous dose of COVID-19 vaccination after their first viral vector vaccine. Heterologous vaccinations could be an effective public health measure to control the pandemic as they are a safe and efficient alternative to homologous regimens. |
format | Online Article Text |
id | pubmed-8910024 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89100242022-03-11 Choosing between Homologous or Heterologous COVID-19 Vaccination Regimens: A Cross-Sectional Study among the General Population in Italy Clari, Marco Godono, Alessandro Albanesi, Beatrice Casabona, Elena Comoretto, Rosanna Irene Mansour, Ihab Conti, Alessio Dimonte, Valerio Ciocan, Catalina Int J Environ Res Public Health Article A shortage of COVID-19 vaccines and reports of side-effects led several countries to recommend a heterologous regimen for second vaccine doses. This study aimed to describe the reasons behind individuals’ choices of a homologous or a heterologous second vaccination. This cross-sectional study enrolled individuals under 60 who had received a first dose of Vaxzevria and could choose between a homologous or heterologous regimen for their second dose. Quantitative (socio-demographic, clinical characteristics) and qualitative data were collected and analysed through a generalized linear model and thematic analysis, respectively. Of the 1437 individuals included in the analysis, the majority (76.1%) chose a heterologous second dose of the COVID-19 vaccination. More females chose a heterologous vaccination regimen (p = 0.003). Younger individuals also tended to choose heterologous vaccination (p < 0.001). The main motivation in favour of heterologous vaccination was to follow the Italian Ministry of Health recommendations (n = 118; 53.9%). This study showed that most individuals, mainly younger people and females, chose a heterologous dose of COVID-19 vaccination after their first viral vector vaccine. Heterologous vaccinations could be an effective public health measure to control the pandemic as they are a safe and efficient alternative to homologous regimens. MDPI 2022-03-03 /pmc/articles/PMC8910024/ /pubmed/35270636 http://dx.doi.org/10.3390/ijerph19052944 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Clari, Marco Godono, Alessandro Albanesi, Beatrice Casabona, Elena Comoretto, Rosanna Irene Mansour, Ihab Conti, Alessio Dimonte, Valerio Ciocan, Catalina Choosing between Homologous or Heterologous COVID-19 Vaccination Regimens: A Cross-Sectional Study among the General Population in Italy |
title | Choosing between Homologous or Heterologous COVID-19 Vaccination Regimens: A Cross-Sectional Study among the General Population in Italy |
title_full | Choosing between Homologous or Heterologous COVID-19 Vaccination Regimens: A Cross-Sectional Study among the General Population in Italy |
title_fullStr | Choosing between Homologous or Heterologous COVID-19 Vaccination Regimens: A Cross-Sectional Study among the General Population in Italy |
title_full_unstemmed | Choosing between Homologous or Heterologous COVID-19 Vaccination Regimens: A Cross-Sectional Study among the General Population in Italy |
title_short | Choosing between Homologous or Heterologous COVID-19 Vaccination Regimens: A Cross-Sectional Study among the General Population in Italy |
title_sort | choosing between homologous or heterologous covid-19 vaccination regimens: a cross-sectional study among the general population in italy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910024/ https://www.ncbi.nlm.nih.gov/pubmed/35270636 http://dx.doi.org/10.3390/ijerph19052944 |
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