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Choosing between Homologous or Heterologous COVID-19 Vaccination Regimens: A Cross-Sectional Study among the General Population in Italy

A shortage of COVID-19 vaccines and reports of side-effects led several countries to recommend a heterologous regimen for second vaccine doses. This study aimed to describe the reasons behind individuals’ choices of a homologous or a heterologous second vaccination. This cross-sectional study enroll...

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Autores principales: Clari, Marco, Godono, Alessandro, Albanesi, Beatrice, Casabona, Elena, Comoretto, Rosanna Irene, Mansour, Ihab, Conti, Alessio, Dimonte, Valerio, Ciocan, Catalina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910024/
https://www.ncbi.nlm.nih.gov/pubmed/35270636
http://dx.doi.org/10.3390/ijerph19052944
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author Clari, Marco
Godono, Alessandro
Albanesi, Beatrice
Casabona, Elena
Comoretto, Rosanna Irene
Mansour, Ihab
Conti, Alessio
Dimonte, Valerio
Ciocan, Catalina
author_facet Clari, Marco
Godono, Alessandro
Albanesi, Beatrice
Casabona, Elena
Comoretto, Rosanna Irene
Mansour, Ihab
Conti, Alessio
Dimonte, Valerio
Ciocan, Catalina
author_sort Clari, Marco
collection PubMed
description A shortage of COVID-19 vaccines and reports of side-effects led several countries to recommend a heterologous regimen for second vaccine doses. This study aimed to describe the reasons behind individuals’ choices of a homologous or a heterologous second vaccination. This cross-sectional study enrolled individuals under 60 who had received a first dose of Vaxzevria and could choose between a homologous or heterologous regimen for their second dose. Quantitative (socio-demographic, clinical characteristics) and qualitative data were collected and analysed through a generalized linear model and thematic analysis, respectively. Of the 1437 individuals included in the analysis, the majority (76.1%) chose a heterologous second dose of the COVID-19 vaccination. More females chose a heterologous vaccination regimen (p = 0.003). Younger individuals also tended to choose heterologous vaccination (p < 0.001). The main motivation in favour of heterologous vaccination was to follow the Italian Ministry of Health recommendations (n = 118; 53.9%). This study showed that most individuals, mainly younger people and females, chose a heterologous dose of COVID-19 vaccination after their first viral vector vaccine. Heterologous vaccinations could be an effective public health measure to control the pandemic as they are a safe and efficient alternative to homologous regimens.
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spelling pubmed-89100242022-03-11 Choosing between Homologous or Heterologous COVID-19 Vaccination Regimens: A Cross-Sectional Study among the General Population in Italy Clari, Marco Godono, Alessandro Albanesi, Beatrice Casabona, Elena Comoretto, Rosanna Irene Mansour, Ihab Conti, Alessio Dimonte, Valerio Ciocan, Catalina Int J Environ Res Public Health Article A shortage of COVID-19 vaccines and reports of side-effects led several countries to recommend a heterologous regimen for second vaccine doses. This study aimed to describe the reasons behind individuals’ choices of a homologous or a heterologous second vaccination. This cross-sectional study enrolled individuals under 60 who had received a first dose of Vaxzevria and could choose between a homologous or heterologous regimen for their second dose. Quantitative (socio-demographic, clinical characteristics) and qualitative data were collected and analysed through a generalized linear model and thematic analysis, respectively. Of the 1437 individuals included in the analysis, the majority (76.1%) chose a heterologous second dose of the COVID-19 vaccination. More females chose a heterologous vaccination regimen (p = 0.003). Younger individuals also tended to choose heterologous vaccination (p < 0.001). The main motivation in favour of heterologous vaccination was to follow the Italian Ministry of Health recommendations (n = 118; 53.9%). This study showed that most individuals, mainly younger people and females, chose a heterologous dose of COVID-19 vaccination after their first viral vector vaccine. Heterologous vaccinations could be an effective public health measure to control the pandemic as they are a safe and efficient alternative to homologous regimens. MDPI 2022-03-03 /pmc/articles/PMC8910024/ /pubmed/35270636 http://dx.doi.org/10.3390/ijerph19052944 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Clari, Marco
Godono, Alessandro
Albanesi, Beatrice
Casabona, Elena
Comoretto, Rosanna Irene
Mansour, Ihab
Conti, Alessio
Dimonte, Valerio
Ciocan, Catalina
Choosing between Homologous or Heterologous COVID-19 Vaccination Regimens: A Cross-Sectional Study among the General Population in Italy
title Choosing between Homologous or Heterologous COVID-19 Vaccination Regimens: A Cross-Sectional Study among the General Population in Italy
title_full Choosing between Homologous or Heterologous COVID-19 Vaccination Regimens: A Cross-Sectional Study among the General Population in Italy
title_fullStr Choosing between Homologous or Heterologous COVID-19 Vaccination Regimens: A Cross-Sectional Study among the General Population in Italy
title_full_unstemmed Choosing between Homologous or Heterologous COVID-19 Vaccination Regimens: A Cross-Sectional Study among the General Population in Italy
title_short Choosing between Homologous or Heterologous COVID-19 Vaccination Regimens: A Cross-Sectional Study among the General Population in Italy
title_sort choosing between homologous or heterologous covid-19 vaccination regimens: a cross-sectional study among the general population in italy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910024/
https://www.ncbi.nlm.nih.gov/pubmed/35270636
http://dx.doi.org/10.3390/ijerph19052944
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