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CXC Chemokine Signaling in Progression of Epithelial Ovarian Cancer: Theranostic Perspectives

Patients with epithelial ovarian cancer (EOC) are often diagnosed at an advanced stage due to nonspecific symptoms and ineffective screening approaches. Although chemotherapy has been available and widely used for the treatment of advanced EOC, the overall prognosis remains dismal. As part of the in...

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Autores principales: Huang, Xinxin, Hao, Juncheng, Tan, Yan Qin, Zhu, Tao, Pandey, Vijay, Lobie, Peter E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910147/
https://www.ncbi.nlm.nih.gov/pubmed/35269786
http://dx.doi.org/10.3390/ijms23052642
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author Huang, Xinxin
Hao, Juncheng
Tan, Yan Qin
Zhu, Tao
Pandey, Vijay
Lobie, Peter E.
author_facet Huang, Xinxin
Hao, Juncheng
Tan, Yan Qin
Zhu, Tao
Pandey, Vijay
Lobie, Peter E.
author_sort Huang, Xinxin
collection PubMed
description Patients with epithelial ovarian cancer (EOC) are often diagnosed at an advanced stage due to nonspecific symptoms and ineffective screening approaches. Although chemotherapy has been available and widely used for the treatment of advanced EOC, the overall prognosis remains dismal. As part of the intrinsic defense mechanisms against cancer development and progression, immune cells are recruited into the tumor microenvironment (TME), and this process is directed by the interactions between different chemokines and their receptors. In this review, the functional significance of CXC chemokine ligands/chemokine receptors (CXCL/CXCR) and their roles in modulating EOC progression are summarized. The status and prospects of CXCR/CXCL-based theranostic strategies in EOC management are also discussed.
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spelling pubmed-89101472022-03-11 CXC Chemokine Signaling in Progression of Epithelial Ovarian Cancer: Theranostic Perspectives Huang, Xinxin Hao, Juncheng Tan, Yan Qin Zhu, Tao Pandey, Vijay Lobie, Peter E. Int J Mol Sci Perspective Patients with epithelial ovarian cancer (EOC) are often diagnosed at an advanced stage due to nonspecific symptoms and ineffective screening approaches. Although chemotherapy has been available and widely used for the treatment of advanced EOC, the overall prognosis remains dismal. As part of the intrinsic defense mechanisms against cancer development and progression, immune cells are recruited into the tumor microenvironment (TME), and this process is directed by the interactions between different chemokines and their receptors. In this review, the functional significance of CXC chemokine ligands/chemokine receptors (CXCL/CXCR) and their roles in modulating EOC progression are summarized. The status and prospects of CXCR/CXCL-based theranostic strategies in EOC management are also discussed. MDPI 2022-02-27 /pmc/articles/PMC8910147/ /pubmed/35269786 http://dx.doi.org/10.3390/ijms23052642 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Perspective
Huang, Xinxin
Hao, Juncheng
Tan, Yan Qin
Zhu, Tao
Pandey, Vijay
Lobie, Peter E.
CXC Chemokine Signaling in Progression of Epithelial Ovarian Cancer: Theranostic Perspectives
title CXC Chemokine Signaling in Progression of Epithelial Ovarian Cancer: Theranostic Perspectives
title_full CXC Chemokine Signaling in Progression of Epithelial Ovarian Cancer: Theranostic Perspectives
title_fullStr CXC Chemokine Signaling in Progression of Epithelial Ovarian Cancer: Theranostic Perspectives
title_full_unstemmed CXC Chemokine Signaling in Progression of Epithelial Ovarian Cancer: Theranostic Perspectives
title_short CXC Chemokine Signaling in Progression of Epithelial Ovarian Cancer: Theranostic Perspectives
title_sort cxc chemokine signaling in progression of epithelial ovarian cancer: theranostic perspectives
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910147/
https://www.ncbi.nlm.nih.gov/pubmed/35269786
http://dx.doi.org/10.3390/ijms23052642
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