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Oxygen-Ozone Therapy for Reducing Pro-Inflammatory Cytokines Serum Levels in Musculoskeletal and Temporomandibular Disorders: A Comprehensive Review

To date, the application of oxygen-ozone (O(2)O(3)) therapy has significantly increased in the common clinical practice in several pathological conditions. However, beyond the favorable clinical effects, the biochemical effects of O(2)O(3) are still far from being understood. This comprehensive revi...

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Autores principales: de Sire, Alessandro, Marotta, Nicola, Ferrillo, Martina, Agostini, Francesco, Sconza, Cristiano, Lippi, Lorenzo, Respizzi, Stefano, Giudice, Amerigo, Invernizzi, Marco, Ammendolia, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910188/
https://www.ncbi.nlm.nih.gov/pubmed/35269681
http://dx.doi.org/10.3390/ijms23052528
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author de Sire, Alessandro
Marotta, Nicola
Ferrillo, Martina
Agostini, Francesco
Sconza, Cristiano
Lippi, Lorenzo
Respizzi, Stefano
Giudice, Amerigo
Invernizzi, Marco
Ammendolia, Antonio
author_facet de Sire, Alessandro
Marotta, Nicola
Ferrillo, Martina
Agostini, Francesco
Sconza, Cristiano
Lippi, Lorenzo
Respizzi, Stefano
Giudice, Amerigo
Invernizzi, Marco
Ammendolia, Antonio
author_sort de Sire, Alessandro
collection PubMed
description To date, the application of oxygen-ozone (O(2)O(3)) therapy has significantly increased in the common clinical practice in several pathological conditions. However, beyond the favorable clinical effects, the biochemical effects of O(2)O(3) are still far from being understood. This comprehensive review aimed at investigating the state of the art about the effects of O(2)O(3) therapy on pro-inflammatory cytokines serum levels as a modulator of oxidative stress in patients with musculoskeletal and temporomandibular disorders (TMD). The efficacy of O(2)O(3) therapy could be related to the moderate oxidative stress modulation produced by the interaction of ozone with biological components. More in detail, O(2)O(3) therapy is widely used as an adjuvant therapeutic option in several pathological conditions characterized by chronic inflammatory processes and immune overactivation. In this context, most musculoskeletal and temporomandibular disorders (TMD) share these two pathophysiological processes. Despite the paucity of in vivo studies, this comprehensive review suggests that O(2)O(3) therapy might reduce serum levels of interleukin 6 in patients with TMD, low back pain, knee osteoarthritis and rheumatic diseases with a concrete and measurable interaction with the inflammatory pathway. However, to date, further studies are needed to clarify the effects of this promising therapy on inflammatory mediators and their clinical implications.
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spelling pubmed-89101882022-03-11 Oxygen-Ozone Therapy for Reducing Pro-Inflammatory Cytokines Serum Levels in Musculoskeletal and Temporomandibular Disorders: A Comprehensive Review de Sire, Alessandro Marotta, Nicola Ferrillo, Martina Agostini, Francesco Sconza, Cristiano Lippi, Lorenzo Respizzi, Stefano Giudice, Amerigo Invernizzi, Marco Ammendolia, Antonio Int J Mol Sci Review To date, the application of oxygen-ozone (O(2)O(3)) therapy has significantly increased in the common clinical practice in several pathological conditions. However, beyond the favorable clinical effects, the biochemical effects of O(2)O(3) are still far from being understood. This comprehensive review aimed at investigating the state of the art about the effects of O(2)O(3) therapy on pro-inflammatory cytokines serum levels as a modulator of oxidative stress in patients with musculoskeletal and temporomandibular disorders (TMD). The efficacy of O(2)O(3) therapy could be related to the moderate oxidative stress modulation produced by the interaction of ozone with biological components. More in detail, O(2)O(3) therapy is widely used as an adjuvant therapeutic option in several pathological conditions characterized by chronic inflammatory processes and immune overactivation. In this context, most musculoskeletal and temporomandibular disorders (TMD) share these two pathophysiological processes. Despite the paucity of in vivo studies, this comprehensive review suggests that O(2)O(3) therapy might reduce serum levels of interleukin 6 in patients with TMD, low back pain, knee osteoarthritis and rheumatic diseases with a concrete and measurable interaction with the inflammatory pathway. However, to date, further studies are needed to clarify the effects of this promising therapy on inflammatory mediators and their clinical implications. MDPI 2022-02-25 /pmc/articles/PMC8910188/ /pubmed/35269681 http://dx.doi.org/10.3390/ijms23052528 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
de Sire, Alessandro
Marotta, Nicola
Ferrillo, Martina
Agostini, Francesco
Sconza, Cristiano
Lippi, Lorenzo
Respizzi, Stefano
Giudice, Amerigo
Invernizzi, Marco
Ammendolia, Antonio
Oxygen-Ozone Therapy for Reducing Pro-Inflammatory Cytokines Serum Levels in Musculoskeletal and Temporomandibular Disorders: A Comprehensive Review
title Oxygen-Ozone Therapy for Reducing Pro-Inflammatory Cytokines Serum Levels in Musculoskeletal and Temporomandibular Disorders: A Comprehensive Review
title_full Oxygen-Ozone Therapy for Reducing Pro-Inflammatory Cytokines Serum Levels in Musculoskeletal and Temporomandibular Disorders: A Comprehensive Review
title_fullStr Oxygen-Ozone Therapy for Reducing Pro-Inflammatory Cytokines Serum Levels in Musculoskeletal and Temporomandibular Disorders: A Comprehensive Review
title_full_unstemmed Oxygen-Ozone Therapy for Reducing Pro-Inflammatory Cytokines Serum Levels in Musculoskeletal and Temporomandibular Disorders: A Comprehensive Review
title_short Oxygen-Ozone Therapy for Reducing Pro-Inflammatory Cytokines Serum Levels in Musculoskeletal and Temporomandibular Disorders: A Comprehensive Review
title_sort oxygen-ozone therapy for reducing pro-inflammatory cytokines serum levels in musculoskeletal and temporomandibular disorders: a comprehensive review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910188/
https://www.ncbi.nlm.nih.gov/pubmed/35269681
http://dx.doi.org/10.3390/ijms23052528
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