Cargando…

COVIDomics: The Proteomic and Metabolomic Signatures of COVID-19

Omics-based technologies have been largely adopted during this unprecedented global COVID-19 pandemic, allowing the scientific community to perform research on a large scale to understand the pathobiology of the SARS-CoV-2 infection and its replication into human cells. The application of omics tech...

Descripción completa

Detalles Bibliográficos
Autores principales: Costanzo, Michele, Caterino, Marianna, Fedele, Roberta, Cevenini, Armando, Pontillo, Mariarca, Barra, Lucia, Ruoppolo, Margherita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910221/
https://www.ncbi.nlm.nih.gov/pubmed/35269564
http://dx.doi.org/10.3390/ijms23052414
_version_ 1784666410156294144
author Costanzo, Michele
Caterino, Marianna
Fedele, Roberta
Cevenini, Armando
Pontillo, Mariarca
Barra, Lucia
Ruoppolo, Margherita
author_facet Costanzo, Michele
Caterino, Marianna
Fedele, Roberta
Cevenini, Armando
Pontillo, Mariarca
Barra, Lucia
Ruoppolo, Margherita
author_sort Costanzo, Michele
collection PubMed
description Omics-based technologies have been largely adopted during this unprecedented global COVID-19 pandemic, allowing the scientific community to perform research on a large scale to understand the pathobiology of the SARS-CoV-2 infection and its replication into human cells. The application of omics techniques has been addressed to every level of application, from the detection of mutations, methods of diagnosis or monitoring, drug target discovery, and vaccine generation, to the basic definition of the pathophysiological processes and the biochemical mechanisms behind the infection and spread of SARS-CoV-2. Thus, the term COVIDomics wants to include those efforts provided by omics-scale investigations with application to the current COVID-19 research. This review summarizes the diverse pieces of knowledge acquired with the application of COVIDomics techniques, with the main focus on proteomics and metabolomics studies, in order to capture a common signature in terms of proteins, metabolites, and pathways dysregulated in COVID-19 disease. Exploring the multiomics perspective and the concurrent data integration may provide new suitable therapeutic solutions to combat the COVID-19 pandemic.
format Online
Article
Text
id pubmed-8910221
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-89102212022-03-11 COVIDomics: The Proteomic and Metabolomic Signatures of COVID-19 Costanzo, Michele Caterino, Marianna Fedele, Roberta Cevenini, Armando Pontillo, Mariarca Barra, Lucia Ruoppolo, Margherita Int J Mol Sci Review Omics-based technologies have been largely adopted during this unprecedented global COVID-19 pandemic, allowing the scientific community to perform research on a large scale to understand the pathobiology of the SARS-CoV-2 infection and its replication into human cells. The application of omics techniques has been addressed to every level of application, from the detection of mutations, methods of diagnosis or monitoring, drug target discovery, and vaccine generation, to the basic definition of the pathophysiological processes and the biochemical mechanisms behind the infection and spread of SARS-CoV-2. Thus, the term COVIDomics wants to include those efforts provided by omics-scale investigations with application to the current COVID-19 research. This review summarizes the diverse pieces of knowledge acquired with the application of COVIDomics techniques, with the main focus on proteomics and metabolomics studies, in order to capture a common signature in terms of proteins, metabolites, and pathways dysregulated in COVID-19 disease. Exploring the multiomics perspective and the concurrent data integration may provide new suitable therapeutic solutions to combat the COVID-19 pandemic. MDPI 2022-02-22 /pmc/articles/PMC8910221/ /pubmed/35269564 http://dx.doi.org/10.3390/ijms23052414 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Costanzo, Michele
Caterino, Marianna
Fedele, Roberta
Cevenini, Armando
Pontillo, Mariarca
Barra, Lucia
Ruoppolo, Margherita
COVIDomics: The Proteomic and Metabolomic Signatures of COVID-19
title COVIDomics: The Proteomic and Metabolomic Signatures of COVID-19
title_full COVIDomics: The Proteomic and Metabolomic Signatures of COVID-19
title_fullStr COVIDomics: The Proteomic and Metabolomic Signatures of COVID-19
title_full_unstemmed COVIDomics: The Proteomic and Metabolomic Signatures of COVID-19
title_short COVIDomics: The Proteomic and Metabolomic Signatures of COVID-19
title_sort covidomics: the proteomic and metabolomic signatures of covid-19
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910221/
https://www.ncbi.nlm.nih.gov/pubmed/35269564
http://dx.doi.org/10.3390/ijms23052414
work_keys_str_mv AT costanzomichele covidomicstheproteomicandmetabolomicsignaturesofcovid19
AT caterinomarianna covidomicstheproteomicandmetabolomicsignaturesofcovid19
AT fedeleroberta covidomicstheproteomicandmetabolomicsignaturesofcovid19
AT ceveniniarmando covidomicstheproteomicandmetabolomicsignaturesofcovid19
AT pontillomariarca covidomicstheproteomicandmetabolomicsignaturesofcovid19
AT barralucia covidomicstheproteomicandmetabolomicsignaturesofcovid19
AT ruoppolomargherita covidomicstheproteomicandmetabolomicsignaturesofcovid19