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COVIDomics: The Proteomic and Metabolomic Signatures of COVID-19
Omics-based technologies have been largely adopted during this unprecedented global COVID-19 pandemic, allowing the scientific community to perform research on a large scale to understand the pathobiology of the SARS-CoV-2 infection and its replication into human cells. The application of omics tech...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910221/ https://www.ncbi.nlm.nih.gov/pubmed/35269564 http://dx.doi.org/10.3390/ijms23052414 |
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author | Costanzo, Michele Caterino, Marianna Fedele, Roberta Cevenini, Armando Pontillo, Mariarca Barra, Lucia Ruoppolo, Margherita |
author_facet | Costanzo, Michele Caterino, Marianna Fedele, Roberta Cevenini, Armando Pontillo, Mariarca Barra, Lucia Ruoppolo, Margherita |
author_sort | Costanzo, Michele |
collection | PubMed |
description | Omics-based technologies have been largely adopted during this unprecedented global COVID-19 pandemic, allowing the scientific community to perform research on a large scale to understand the pathobiology of the SARS-CoV-2 infection and its replication into human cells. The application of omics techniques has been addressed to every level of application, from the detection of mutations, methods of diagnosis or monitoring, drug target discovery, and vaccine generation, to the basic definition of the pathophysiological processes and the biochemical mechanisms behind the infection and spread of SARS-CoV-2. Thus, the term COVIDomics wants to include those efforts provided by omics-scale investigations with application to the current COVID-19 research. This review summarizes the diverse pieces of knowledge acquired with the application of COVIDomics techniques, with the main focus on proteomics and metabolomics studies, in order to capture a common signature in terms of proteins, metabolites, and pathways dysregulated in COVID-19 disease. Exploring the multiomics perspective and the concurrent data integration may provide new suitable therapeutic solutions to combat the COVID-19 pandemic. |
format | Online Article Text |
id | pubmed-8910221 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89102212022-03-11 COVIDomics: The Proteomic and Metabolomic Signatures of COVID-19 Costanzo, Michele Caterino, Marianna Fedele, Roberta Cevenini, Armando Pontillo, Mariarca Barra, Lucia Ruoppolo, Margherita Int J Mol Sci Review Omics-based technologies have been largely adopted during this unprecedented global COVID-19 pandemic, allowing the scientific community to perform research on a large scale to understand the pathobiology of the SARS-CoV-2 infection and its replication into human cells. The application of omics techniques has been addressed to every level of application, from the detection of mutations, methods of diagnosis or monitoring, drug target discovery, and vaccine generation, to the basic definition of the pathophysiological processes and the biochemical mechanisms behind the infection and spread of SARS-CoV-2. Thus, the term COVIDomics wants to include those efforts provided by omics-scale investigations with application to the current COVID-19 research. This review summarizes the diverse pieces of knowledge acquired with the application of COVIDomics techniques, with the main focus on proteomics and metabolomics studies, in order to capture a common signature in terms of proteins, metabolites, and pathways dysregulated in COVID-19 disease. Exploring the multiomics perspective and the concurrent data integration may provide new suitable therapeutic solutions to combat the COVID-19 pandemic. MDPI 2022-02-22 /pmc/articles/PMC8910221/ /pubmed/35269564 http://dx.doi.org/10.3390/ijms23052414 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Costanzo, Michele Caterino, Marianna Fedele, Roberta Cevenini, Armando Pontillo, Mariarca Barra, Lucia Ruoppolo, Margherita COVIDomics: The Proteomic and Metabolomic Signatures of COVID-19 |
title | COVIDomics: The Proteomic and Metabolomic Signatures of COVID-19 |
title_full | COVIDomics: The Proteomic and Metabolomic Signatures of COVID-19 |
title_fullStr | COVIDomics: The Proteomic and Metabolomic Signatures of COVID-19 |
title_full_unstemmed | COVIDomics: The Proteomic and Metabolomic Signatures of COVID-19 |
title_short | COVIDomics: The Proteomic and Metabolomic Signatures of COVID-19 |
title_sort | covidomics: the proteomic and metabolomic signatures of covid-19 |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910221/ https://www.ncbi.nlm.nih.gov/pubmed/35269564 http://dx.doi.org/10.3390/ijms23052414 |
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