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Human Papillomavirus Self-Sampling for Primary Cervical Cancer Screening in Under-Screened Women in Hong Kong during the COVID-19 Pandemic

The aim of this study was to assess the effectiveness of HPV self-sampling for cervical cancer screening and the best means of service delivery, with a specific focus on under-screened women, particularly during the COVID-19 pandemic. Using three arms of service delivery (social media, school outrea...

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Autores principales: Ngu, Siew-Fei, Lau, Lesley S. K., Li, Justin, Wong, Grace C. Y., Cheung, Annie N. Y., Ngan, Hextan Y. S., Chan, Karen K. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910259/
https://www.ncbi.nlm.nih.gov/pubmed/35270303
http://dx.doi.org/10.3390/ijerph19052610
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author Ngu, Siew-Fei
Lau, Lesley S. K.
Li, Justin
Wong, Grace C. Y.
Cheung, Annie N. Y.
Ngan, Hextan Y. S.
Chan, Karen K. L.
author_facet Ngu, Siew-Fei
Lau, Lesley S. K.
Li, Justin
Wong, Grace C. Y.
Cheung, Annie N. Y.
Ngan, Hextan Y. S.
Chan, Karen K. L.
author_sort Ngu, Siew-Fei
collection PubMed
description The aim of this study was to assess the effectiveness of HPV self-sampling for cervical cancer screening and the best means of service delivery, with a specific focus on under-screened women, particularly during the COVID-19 pandemic. Using three arms of service delivery (social media, school outreach and underserved outreach), we recruited under-screened women aged 30–65 years from two population groups: the general public and specific underserved communities, from whom self-sampled specimens and optional clinician-sampled cervical specimens were obtained for HPV testing. A total of 521 self-sampling kits were distributed, of which 321 were returned, giving an overall uptake rate of 61.6%. The response rate was higher in the face-to-face underserved outreach (65.5%) compared to social media (22.8%) and school outreach (18.2%). The concordance for HPV detection between self-sampled and clinician-sampled specimens was 90.2% [95% confidence interval (CI) 85.1–93.8%; Cohen’s kappa 0.59 (95% CI 0.42–0.75)]. Overall, 89.2% of women were willing to have self-sampling again. In conclusion, HPV self-sampling is an effective method for cervical cancer screening and can be considered as an option, particularly in women who are reluctant or unable to attend regular screening. Various service deliveries could be considered to increase participation in cervical cancer screening.
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spelling pubmed-89102592022-03-11 Human Papillomavirus Self-Sampling for Primary Cervical Cancer Screening in Under-Screened Women in Hong Kong during the COVID-19 Pandemic Ngu, Siew-Fei Lau, Lesley S. K. Li, Justin Wong, Grace C. Y. Cheung, Annie N. Y. Ngan, Hextan Y. S. Chan, Karen K. L. Int J Environ Res Public Health Article The aim of this study was to assess the effectiveness of HPV self-sampling for cervical cancer screening and the best means of service delivery, with a specific focus on under-screened women, particularly during the COVID-19 pandemic. Using three arms of service delivery (social media, school outreach and underserved outreach), we recruited under-screened women aged 30–65 years from two population groups: the general public and specific underserved communities, from whom self-sampled specimens and optional clinician-sampled cervical specimens were obtained for HPV testing. A total of 521 self-sampling kits were distributed, of which 321 were returned, giving an overall uptake rate of 61.6%. The response rate was higher in the face-to-face underserved outreach (65.5%) compared to social media (22.8%) and school outreach (18.2%). The concordance for HPV detection between self-sampled and clinician-sampled specimens was 90.2% [95% confidence interval (CI) 85.1–93.8%; Cohen’s kappa 0.59 (95% CI 0.42–0.75)]. Overall, 89.2% of women were willing to have self-sampling again. In conclusion, HPV self-sampling is an effective method for cervical cancer screening and can be considered as an option, particularly in women who are reluctant or unable to attend regular screening. Various service deliveries could be considered to increase participation in cervical cancer screening. MDPI 2022-02-24 /pmc/articles/PMC8910259/ /pubmed/35270303 http://dx.doi.org/10.3390/ijerph19052610 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ngu, Siew-Fei
Lau, Lesley S. K.
Li, Justin
Wong, Grace C. Y.
Cheung, Annie N. Y.
Ngan, Hextan Y. S.
Chan, Karen K. L.
Human Papillomavirus Self-Sampling for Primary Cervical Cancer Screening in Under-Screened Women in Hong Kong during the COVID-19 Pandemic
title Human Papillomavirus Self-Sampling for Primary Cervical Cancer Screening in Under-Screened Women in Hong Kong during the COVID-19 Pandemic
title_full Human Papillomavirus Self-Sampling for Primary Cervical Cancer Screening in Under-Screened Women in Hong Kong during the COVID-19 Pandemic
title_fullStr Human Papillomavirus Self-Sampling for Primary Cervical Cancer Screening in Under-Screened Women in Hong Kong during the COVID-19 Pandemic
title_full_unstemmed Human Papillomavirus Self-Sampling for Primary Cervical Cancer Screening in Under-Screened Women in Hong Kong during the COVID-19 Pandemic
title_short Human Papillomavirus Self-Sampling for Primary Cervical Cancer Screening in Under-Screened Women in Hong Kong during the COVID-19 Pandemic
title_sort human papillomavirus self-sampling for primary cervical cancer screening in under-screened women in hong kong during the covid-19 pandemic
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910259/
https://www.ncbi.nlm.nih.gov/pubmed/35270303
http://dx.doi.org/10.3390/ijerph19052610
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