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Transcriptomic and Network Analyses Reveal Immune Modulation by Endocannabinoids in Approach/Avoidance Traits
Approach and avoidance (A/A) tendencies are stable behavioral traits in responding to rewarding and fearful stimuli. They represent the superordinate division of emotion, and individual differences in such traits are associated with disease susceptibility. The neural circuitry underlying A/A traits...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910341/ https://www.ncbi.nlm.nih.gov/pubmed/35269678 http://dx.doi.org/10.3390/ijms23052538 |
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author | Termine, Andrea Fabrizio, Carlo Gimenez, Juliette Panuccio, Anna Balsamo, Francesca Passarello, Noemi Caioli, Silvia Saba, Luana De Bardi, Marco Della Valle, Francesco Orlando, Valerio Petrosini, Laura Laricchiuta, Daniela |
author_facet | Termine, Andrea Fabrizio, Carlo Gimenez, Juliette Panuccio, Anna Balsamo, Francesca Passarello, Noemi Caioli, Silvia Saba, Luana De Bardi, Marco Della Valle, Francesco Orlando, Valerio Petrosini, Laura Laricchiuta, Daniela |
author_sort | Termine, Andrea |
collection | PubMed |
description | Approach and avoidance (A/A) tendencies are stable behavioral traits in responding to rewarding and fearful stimuli. They represent the superordinate division of emotion, and individual differences in such traits are associated with disease susceptibility. The neural circuitry underlying A/A traits is retained to be the cortico-limbic pathway including the amygdala, the central hub for the emotional processing. Furthermore, A/A-specific individual differences are associated with the activity of the endocannabinoid system (ECS) and especially of CB1 receptors whose density and functionality in amygdala differ according to A/A traits. ECS markedly interacts with the immune system (IS). However, how the interplay between ECS and IS is associated with A/A individual differences is still ill-defined. To fill this gap, here we analyzed the interaction between the gene expression of ECS and immune system (IS) in relation to individual differences. To unveil the deep architecture of ECS-IS interaction, we performed cell-specific transcriptomics analysis. Differential gene expression profiling, functional enrichment, and protein–protein interaction network analyses were performed in amygdala pyramidal neurons of mice showing different A/A behavioral tendencies. Several altered pro-inflammatory pathways were identified as associated with individual differences in A/A traits, indicating the chronic activation of the adaptive immune response sustained by the interplay between endocannabinoids and the IS. Furthermore, results showed that the interaction between the two systems modulates synaptic plasticity and neuronal metabolism in individual difference-specific manner. Deepening our knowledge about ECS/IS interaction may provide useful targets for treatment and prevention of psychopathology associated with A/A traits. |
format | Online Article Text |
id | pubmed-8910341 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89103412022-03-11 Transcriptomic and Network Analyses Reveal Immune Modulation by Endocannabinoids in Approach/Avoidance Traits Termine, Andrea Fabrizio, Carlo Gimenez, Juliette Panuccio, Anna Balsamo, Francesca Passarello, Noemi Caioli, Silvia Saba, Luana De Bardi, Marco Della Valle, Francesco Orlando, Valerio Petrosini, Laura Laricchiuta, Daniela Int J Mol Sci Article Approach and avoidance (A/A) tendencies are stable behavioral traits in responding to rewarding and fearful stimuli. They represent the superordinate division of emotion, and individual differences in such traits are associated with disease susceptibility. The neural circuitry underlying A/A traits is retained to be the cortico-limbic pathway including the amygdala, the central hub for the emotional processing. Furthermore, A/A-specific individual differences are associated with the activity of the endocannabinoid system (ECS) and especially of CB1 receptors whose density and functionality in amygdala differ according to A/A traits. ECS markedly interacts with the immune system (IS). However, how the interplay between ECS and IS is associated with A/A individual differences is still ill-defined. To fill this gap, here we analyzed the interaction between the gene expression of ECS and immune system (IS) in relation to individual differences. To unveil the deep architecture of ECS-IS interaction, we performed cell-specific transcriptomics analysis. Differential gene expression profiling, functional enrichment, and protein–protein interaction network analyses were performed in amygdala pyramidal neurons of mice showing different A/A behavioral tendencies. Several altered pro-inflammatory pathways were identified as associated with individual differences in A/A traits, indicating the chronic activation of the adaptive immune response sustained by the interplay between endocannabinoids and the IS. Furthermore, results showed that the interaction between the two systems modulates synaptic plasticity and neuronal metabolism in individual difference-specific manner. Deepening our knowledge about ECS/IS interaction may provide useful targets for treatment and prevention of psychopathology associated with A/A traits. MDPI 2022-02-25 /pmc/articles/PMC8910341/ /pubmed/35269678 http://dx.doi.org/10.3390/ijms23052538 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Termine, Andrea Fabrizio, Carlo Gimenez, Juliette Panuccio, Anna Balsamo, Francesca Passarello, Noemi Caioli, Silvia Saba, Luana De Bardi, Marco Della Valle, Francesco Orlando, Valerio Petrosini, Laura Laricchiuta, Daniela Transcriptomic and Network Analyses Reveal Immune Modulation by Endocannabinoids in Approach/Avoidance Traits |
title | Transcriptomic and Network Analyses Reveal Immune Modulation by Endocannabinoids in Approach/Avoidance Traits |
title_full | Transcriptomic and Network Analyses Reveal Immune Modulation by Endocannabinoids in Approach/Avoidance Traits |
title_fullStr | Transcriptomic and Network Analyses Reveal Immune Modulation by Endocannabinoids in Approach/Avoidance Traits |
title_full_unstemmed | Transcriptomic and Network Analyses Reveal Immune Modulation by Endocannabinoids in Approach/Avoidance Traits |
title_short | Transcriptomic and Network Analyses Reveal Immune Modulation by Endocannabinoids in Approach/Avoidance Traits |
title_sort | transcriptomic and network analyses reveal immune modulation by endocannabinoids in approach/avoidance traits |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910341/ https://www.ncbi.nlm.nih.gov/pubmed/35269678 http://dx.doi.org/10.3390/ijms23052538 |
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