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Synergistic and Detrimental Effects of Alcohol Intake on Progression of Liver Steatosis

Nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) are the most common liver disorders worldwide and the major causes of non-viral liver cirrhosis in the general population. In NAFLD, metabolic abnormalities, obesity, and metabolic syndrome are the driving factors for liver d...

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Autores principales: Di Ciaula, Agostino, Bonfrate, Leonilde, Krawczyk, Marcin, Frühbeck, Gema, Portincasa, Piero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910376/
https://www.ncbi.nlm.nih.gov/pubmed/35269779
http://dx.doi.org/10.3390/ijms23052636
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author Di Ciaula, Agostino
Bonfrate, Leonilde
Krawczyk, Marcin
Frühbeck, Gema
Portincasa, Piero
author_facet Di Ciaula, Agostino
Bonfrate, Leonilde
Krawczyk, Marcin
Frühbeck, Gema
Portincasa, Piero
author_sort Di Ciaula, Agostino
collection PubMed
description Nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) are the most common liver disorders worldwide and the major causes of non-viral liver cirrhosis in the general population. In NAFLD, metabolic abnormalities, obesity, and metabolic syndrome are the driving factors for liver damage with no or minimal alcohol consumption. ALD refers to liver damage caused by excess alcohol intake in individuals drinking more than 5 to 10 daily units for years. Although NAFLD and ALD are nosologically considered two distinct entities, they show a continuum and exert synergistic effects on the progression toward liver cirrhosis. The current view is that low alcohol use might also increase the risk of advanced clinical liver disease in NAFLD, whereas metabolic factors increase the risk of cirrhosis among alcohol risk drinkers. Therefore, special interest is now addressed to individuals with metabolic abnormalities who consume small amounts of alcohol or who binge drink, for the role of light-to-moderate alcohol use in fibrosis progression and clinical severity of the liver disease. Evidence shows that in the presence of NAFLD, there is no liver-safe limit of alcohol intake. We discuss the epidemiological and clinical features of NAFLD/ALD, aspects of alcohol metabolism, and mechanisms of damage concerning steatosis, fibrosis, cumulative effects, and deleterious consequences which include hepatocellular carcinoma.
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spelling pubmed-89103762022-03-11 Synergistic and Detrimental Effects of Alcohol Intake on Progression of Liver Steatosis Di Ciaula, Agostino Bonfrate, Leonilde Krawczyk, Marcin Frühbeck, Gema Portincasa, Piero Int J Mol Sci Review Nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) are the most common liver disorders worldwide and the major causes of non-viral liver cirrhosis in the general population. In NAFLD, metabolic abnormalities, obesity, and metabolic syndrome are the driving factors for liver damage with no or minimal alcohol consumption. ALD refers to liver damage caused by excess alcohol intake in individuals drinking more than 5 to 10 daily units for years. Although NAFLD and ALD are nosologically considered two distinct entities, they show a continuum and exert synergistic effects on the progression toward liver cirrhosis. The current view is that low alcohol use might also increase the risk of advanced clinical liver disease in NAFLD, whereas metabolic factors increase the risk of cirrhosis among alcohol risk drinkers. Therefore, special interest is now addressed to individuals with metabolic abnormalities who consume small amounts of alcohol or who binge drink, for the role of light-to-moderate alcohol use in fibrosis progression and clinical severity of the liver disease. Evidence shows that in the presence of NAFLD, there is no liver-safe limit of alcohol intake. We discuss the epidemiological and clinical features of NAFLD/ALD, aspects of alcohol metabolism, and mechanisms of damage concerning steatosis, fibrosis, cumulative effects, and deleterious consequences which include hepatocellular carcinoma. MDPI 2022-02-27 /pmc/articles/PMC8910376/ /pubmed/35269779 http://dx.doi.org/10.3390/ijms23052636 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Di Ciaula, Agostino
Bonfrate, Leonilde
Krawczyk, Marcin
Frühbeck, Gema
Portincasa, Piero
Synergistic and Detrimental Effects of Alcohol Intake on Progression of Liver Steatosis
title Synergistic and Detrimental Effects of Alcohol Intake on Progression of Liver Steatosis
title_full Synergistic and Detrimental Effects of Alcohol Intake on Progression of Liver Steatosis
title_fullStr Synergistic and Detrimental Effects of Alcohol Intake on Progression of Liver Steatosis
title_full_unstemmed Synergistic and Detrimental Effects of Alcohol Intake on Progression of Liver Steatosis
title_short Synergistic and Detrimental Effects of Alcohol Intake on Progression of Liver Steatosis
title_sort synergistic and detrimental effects of alcohol intake on progression of liver steatosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910376/
https://www.ncbi.nlm.nih.gov/pubmed/35269779
http://dx.doi.org/10.3390/ijms23052636
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