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How Comorbidities Affect Hospitalization from Influenza in the Pediatric Population

Influenza is a contagious respiratory illness and can lead to hospitalization and even death. Understanding how comorbidities affect the severity of influenza can help clinical management. The aim of this study is to offer more information about comorbidities that might be associated with the severi...

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Autores principales: Mylonakis, Sophia C., Mylona, Evangelia K., Kalligeros, Markos, Shehadeh, Fadi, Chan, Philip A., Mylonakis, Eleftherios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910429/
https://www.ncbi.nlm.nih.gov/pubmed/35270503
http://dx.doi.org/10.3390/ijerph19052811
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author Mylonakis, Sophia C.
Mylona, Evangelia K.
Kalligeros, Markos
Shehadeh, Fadi
Chan, Philip A.
Mylonakis, Eleftherios
author_facet Mylonakis, Sophia C.
Mylona, Evangelia K.
Kalligeros, Markos
Shehadeh, Fadi
Chan, Philip A.
Mylonakis, Eleftherios
author_sort Mylonakis, Sophia C.
collection PubMed
description Influenza is a contagious respiratory illness and can lead to hospitalization and even death. Understanding how comorbidities affect the severity of influenza can help clinical management. The aim of this study is to offer more information about comorbidities that might be associated with the severity of influenza in children. We used a statewide network in Rhode Island, USA, to extract data for laboratory-confirmed influenza cases among children 19 years old or younger. We identified 1169 lab-confirmed influenza cases. The most common comorbidities were asthma (17.1%), neurodevelopmental disorders (10.3%), gastrointestinal disorders (7.6%), atopic dermatitis (7%), and endocrine and metabolic diseases (6.8%). Interestingly, 80.8% (63 out of 78) of children who had an influenza-related hospital admission had at least one comorbidity, and among hospitalized children with influenza, the most common comorbidities were neurological diseases (28.2%, 22/78), gastrointestinal disorders (25.6%, 20/78), endocrine and metabolic diseases (24.4%, 19/78), and neurodevelopmental disorders (23.1%, 18/78). Children with endocrine or metabolic diseases were 8.23 times more likely to be admitted to the hospital, and children with neurological disorders were 6.35 times more likely to be admitted (OR: 8.23, 95% CI: 4.42–15.32 and OR: 6.35, 95% CI: 3.60–11.24, respectively). In summary, we identified specific comorbidities associated with influenza hospitalization and length of hospital stay, and these groups should be prioritized for public health interventions.
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spelling pubmed-89104292022-03-11 How Comorbidities Affect Hospitalization from Influenza in the Pediatric Population Mylonakis, Sophia C. Mylona, Evangelia K. Kalligeros, Markos Shehadeh, Fadi Chan, Philip A. Mylonakis, Eleftherios Int J Environ Res Public Health Article Influenza is a contagious respiratory illness and can lead to hospitalization and even death. Understanding how comorbidities affect the severity of influenza can help clinical management. The aim of this study is to offer more information about comorbidities that might be associated with the severity of influenza in children. We used a statewide network in Rhode Island, USA, to extract data for laboratory-confirmed influenza cases among children 19 years old or younger. We identified 1169 lab-confirmed influenza cases. The most common comorbidities were asthma (17.1%), neurodevelopmental disorders (10.3%), gastrointestinal disorders (7.6%), atopic dermatitis (7%), and endocrine and metabolic diseases (6.8%). Interestingly, 80.8% (63 out of 78) of children who had an influenza-related hospital admission had at least one comorbidity, and among hospitalized children with influenza, the most common comorbidities were neurological diseases (28.2%, 22/78), gastrointestinal disorders (25.6%, 20/78), endocrine and metabolic diseases (24.4%, 19/78), and neurodevelopmental disorders (23.1%, 18/78). Children with endocrine or metabolic diseases were 8.23 times more likely to be admitted to the hospital, and children with neurological disorders were 6.35 times more likely to be admitted (OR: 8.23, 95% CI: 4.42–15.32 and OR: 6.35, 95% CI: 3.60–11.24, respectively). In summary, we identified specific comorbidities associated with influenza hospitalization and length of hospital stay, and these groups should be prioritized for public health interventions. MDPI 2022-02-28 /pmc/articles/PMC8910429/ /pubmed/35270503 http://dx.doi.org/10.3390/ijerph19052811 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mylonakis, Sophia C.
Mylona, Evangelia K.
Kalligeros, Markos
Shehadeh, Fadi
Chan, Philip A.
Mylonakis, Eleftherios
How Comorbidities Affect Hospitalization from Influenza in the Pediatric Population
title How Comorbidities Affect Hospitalization from Influenza in the Pediatric Population
title_full How Comorbidities Affect Hospitalization from Influenza in the Pediatric Population
title_fullStr How Comorbidities Affect Hospitalization from Influenza in the Pediatric Population
title_full_unstemmed How Comorbidities Affect Hospitalization from Influenza in the Pediatric Population
title_short How Comorbidities Affect Hospitalization from Influenza in the Pediatric Population
title_sort how comorbidities affect hospitalization from influenza in the pediatric population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910429/
https://www.ncbi.nlm.nih.gov/pubmed/35270503
http://dx.doi.org/10.3390/ijerph19052811
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