Cargando…

A Redox-Silent Analogue of Tocotrienol May Break the Homeostasis of Proteasomes in Human Malignant Mesothelioma Cells by Inhibiting STAT3 and NRF1

6-O-Carboxypropyl-alpha-tocotrienol (α-T3E) is a multi-target redox-silent analogue of tocotrienol that exhibits cytotoxicity against many cancer cells, including malignant mesothelioma (MM) cells. α-T3E has several molecular targets to effectively induce cytotoxicity against MM cells; however, the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ishii, Kyota, Fusegi, Momoka, Mori, Tatsuki, Teshima, Kosuke, Ninomiya, Nanako, Kohno, Kakeru, Sato, Ayami, Ishida, Tatsuya, Miyakoshi, Yuichi, Yano, Tomohiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910454/ https://www.ncbi.nlm.nih.gov/pubmed/35269802 http://dx.doi.org/10.3390/ijms23052655

Ejemplares similares

α-Tocotrienol and Redox-Silent Analogs of Vitamin E Enhances Bortezomib Sensitivity in Solid Cancer Cells through Modulation of NFE2L1
por: Ishii, Kyota, et al.
Publicado: (2023)

466 Development of a novel tocotrienol analogue, tocoflexol, as a radiomitigator
por: Shrimali, Shivangi, et al.
Publicado: (2023)

Synthesis of [(18)F]F-γ-T-3, a Redox-Silent γ-Tocotrienol (γ-T-3) Vitamin E Analogue for Image-Based In Vivo Studies of Vitamin E Biodistribution and Dynamics
por: Roselt, Peter, et al.
Publicado: (2020)

Transcriptomic Analysis of the Anticancer Effects of Annatto Tocotrienol, Delta-Tocotrienol and Gamma-Tocotrienol on Chondrosarcoma Cells
por: Pang, Kok-Lun, et al.
Publicado: (2022)

Resveratrol can induce differentiating phenotypes in canine oral mucosal melanoma cells
por: FUKUOKA, Nana, et al.
Publicado: (2023)

Withaferin A Inhibits the Proteasome Activity in Mesothelioma In Vitro and In Vivo
por: Yang, Huanjie, et al.
Publicado: (2012)

Alpha-tocotrienol is the most abundant tocotrienol isomer circulated in plasma and lipoproteins after postprandial tocotrienol-rich vitamin E supplementation
por: Fairus, Syed, et al.
Publicado: (2012)

Proteasomal degradation of polycomb-group protein CBX6 confers MMP-2 expression essential for mesothelioma invasion
por: Sakai, Katsuya, et al.
Publicado: (2020)

Correction: Withaferin A Inhibits the Proteasome Activity in Mesothelioma In Vitro and In Vivo
por: Yang, Huanjie, et al.
Publicado: (2013)

Tocotrienols: Exciting Biological and Pharmacological Properties of Tocotrienols and Naturally Occurring Compounds, Part II
por: Qureshi, Asaf A
Publicado: (2022)

Cerebellar Transcranial Magnetic Stimulation Reduces the Silent Period on Hand Muscle Electromyography During Force Control
por: Matsugi, Akiyoshi, et al.
Publicado: (2020)

Revisiting the therapeutic potential of tocotrienol
por: Ranasinghe, Ranmali, et al.
Publicado: (2022)

Transmucosal Delivery of Tocotrienols From a Delta-Tocotrienol Powder: A Multidose Pharmacokinetic Study
por: Moon, Jordan, et al.
Publicado: (2022)

Tocotrienols: Exciting Biological and Pharmacological Properties of Tocotrienols and other Naturally Occurring Compounds, Part I
por: Qureshi, AA
Publicado: (2022)

Advancing the Role of Gamma-Tocotrienol as Proteasomes Inhibitor: A Quantitative Proteomic Analysis of MDA-MB-231 Human Breast Cancer Cells
por: Ramdas, Premdass, et al.
Publicado: (2019)

Proteasome stress sensitizes malignant pleural mesothelioma cells to bortezomib-induced apoptosis
por: Cerruti, Fulvia, et al.
Publicado: (2017)

Bioavailability of tocotrienols: evidence in human studies
por: Fu, Ju-Yen, et al.
Publicado: (2014)

Pharmacological potential of tocotrienols: a review
por: Ahsan, Haseeb, et al.
Publicado: (2014)

Tocotrienol regulates osteoclastogenesis in rheumatoid arthritis
por: Kim, Kyoung-Woon, et al.
Publicado: (2021)

Tocotrienols as an Anti-Breast Cancer Agent
por: Trujillo, Madison, et al.
Publicado: (2021)

Vitamin E δ-tocotrienol sensitizes human pancreatic cancer cells to TRAIL-induced apoptosis through proteasome-mediated down-regulation of c-FLIP(s)
por: Francois, Rony A., et al.
Publicado: (2019)

Synthesis and Characterization of Octacyano-Fe-Phthalocyanine
por: Isobe, Momoka, et al.
Publicado: (2023)

Inhibition of Human and Yeast 20S Proteasome by Analogues of Trypsin Inhibitor SFTI-1
por: Dębowski, Dawid, et al.
Publicado: (2014)

Development of Tyrphostin Analogues to Study Inhibition of the Mycobacterium tuberculosis Pup Proteasome System
por: Janssen, Guido V., et al.
Publicado: (2021)

Tocotrienols are good adjuvants for developing cancer vaccines
por: Abdul Hafid, Sitti Rahma, et al.
Publicado: (2010)

Tocopherol and tocotrienol homologs in parenteral lipid emulsions
por: Xu, Zhidong, et al.
Publicado: (2015)

Biological Properties of Tocotrienols: Evidence in Human Studies
por: Meganathan, Puvaneswari, et al.
Publicado: (2016)

The Role of Tocotrienol in Protecting Against Metabolic Diseases
por: Pang, Kok-Lun, et al.
Publicado: (2019)

An Update on Vitamin E, Tocopherol and Tocotrienol—Perspectives
por: Colombo, Maria Laura
Publicado: (2010)

An Interactive Review on the Role of Tocotrienols in the Neurodegenerative Disorders
por: Naomi, Ruth, et al.
Publicado: (2021)

Tocotrienol in the Treatment of Topical Wounds: Recent Updates
por: Nair, Anroop B., et al.
Publicado: (2022)

Tocotrienol Rich Palm Oil Extract Is More Effective Than Pure Tocotrienols at Improving Endothelium-Dependent Relaxation in the Presence of Oxidative Stress
por: Ali, Saher F., et al.
Publicado: (2015)

A new formulation of Gamma Delta Tocotrienol has superior bioavailability compared to existing Tocotrienol-Rich Fraction in healthy human subjects
por: Meganathan, Puvaneswari, et al.
Publicado: (2015)

Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core
por: da Fonseca, Paula C.A., et al.
Publicado: (2015)

Cystargolide-based amide and ester Pz analogues as proteasome inhibitors and anti-cancer agents
por: Viera, Carlos R., et al.
Publicado: (2022)

Attenuation of lipopolysaccharide (LPS)-induced cytotoxicity by tocopherols and tocotrienols()
por: Nishio, Keiko, et al.
Publicado: (2013)

Vitamin E: tocopherols and tocotrienols as potential radiation countermeasures
por: Singh, Vijay K., et al.
Publicado: (2013)

Reversal of Myoblast Aging by Tocotrienol Rich Fraction Posttreatment
por: Lim, Jing Jye, et al.
Publicado: (2013)

Tocotrienol improves learning and memory deficit of aged rats
por: Kaneai, Nozomi, et al.
Publicado: (2016)

Progenitors Mobilized by Gamma-Tocotrienol as an Effective Radiation Countermeasure
por: Singh, Vijay K., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_0qq778hlaj65anh80v2pg0trs8