Functional Conversion of Acetyl-Coenzyme a Synthase to a Nickel Superoxide Dismutase via Rational Design of Coordination Microenvironment for the Ni(d)-Site

The Ni(d) site coordination microenvironment of a truncated acetyl-coenzyme A synthase has been designed systematically for functional conversion to a Ni-SOD-like enzyme. To this end, the first strategy is to introduce an axial histidine ligand, using mutations F598H, S594H and S594H-GP individually...

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Detalles Bibliográficos
Autores principales: Wei, Yaozhu, Zhou, Yajun, Yuan, Hong, Liu, Yi, Lin, Ying-Wu, Su, Jihu, Tan, Xiangshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910529/
https://www.ncbi.nlm.nih.gov/pubmed/35269794
http://dx.doi.org/10.3390/ijms23052652

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