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Bone Reconstruction Using Two-Layer Porcine-Derived Bone Scaffold Composed of Cortical and Cancellous Bones in a Rabbit Calvarial Defect Model

In this study, we aimed to investigate the bone regeneration efficiency of two-layer porcine-derived bone scaffolds composed of cancellous and cortical bones in a rabbit calvarial defect model. Four circular calvaria defects were formed on cranium of rabbit and were filled with block bone scaffolds...

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Autores principales: Seo, Yong-Ho, Hwang, Su-Hyun, Kim, Yu-Na, Kim, Hyung-Joon, Bae, Eun-Bin, Huh, Jung-Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910567/
https://www.ncbi.nlm.nih.gov/pubmed/35269791
http://dx.doi.org/10.3390/ijms23052647
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author Seo, Yong-Ho
Hwang, Su-Hyun
Kim, Yu-Na
Kim, Hyung-Joon
Bae, Eun-Bin
Huh, Jung-Bo
author_facet Seo, Yong-Ho
Hwang, Su-Hyun
Kim, Yu-Na
Kim, Hyung-Joon
Bae, Eun-Bin
Huh, Jung-Bo
author_sort Seo, Yong-Ho
collection PubMed
description In this study, we aimed to investigate the bone regeneration efficiency of two-layer porcine-derived bone scaffolds composed of cancellous and cortical bones in a rabbit calvarial defect model. Four circular calvaria defects were formed on cranium of rabbit and were filled with block bone scaffolds of each group: cortical bone block (Cortical group), cancellous bone block (Cancellous group), and two-layer bone block (2layer group). After 8 weeks, new bones were primarily observed in cancellous parts of the Cancellous and 2layer groups, while the Cortical group exhibited few new bones. In the results of new bone volume and area analyses, the Cancellous group showed the highest value, followed by the 2layer group, and were significantly higher than the Cortical group. Within the limitations of this study, the cancellous and two-layer porcine-derived bone scaffolds showed satisfactory bone regeneration efficiency; further studies on regulating the ratio of cortical and cancellous bones in two-layer bones are needed.
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spelling pubmed-89105672022-03-11 Bone Reconstruction Using Two-Layer Porcine-Derived Bone Scaffold Composed of Cortical and Cancellous Bones in a Rabbit Calvarial Defect Model Seo, Yong-Ho Hwang, Su-Hyun Kim, Yu-Na Kim, Hyung-Joon Bae, Eun-Bin Huh, Jung-Bo Int J Mol Sci Article In this study, we aimed to investigate the bone regeneration efficiency of two-layer porcine-derived bone scaffolds composed of cancellous and cortical bones in a rabbit calvarial defect model. Four circular calvaria defects were formed on cranium of rabbit and were filled with block bone scaffolds of each group: cortical bone block (Cortical group), cancellous bone block (Cancellous group), and two-layer bone block (2layer group). After 8 weeks, new bones were primarily observed in cancellous parts of the Cancellous and 2layer groups, while the Cortical group exhibited few new bones. In the results of new bone volume and area analyses, the Cancellous group showed the highest value, followed by the 2layer group, and were significantly higher than the Cortical group. Within the limitations of this study, the cancellous and two-layer porcine-derived bone scaffolds showed satisfactory bone regeneration efficiency; further studies on regulating the ratio of cortical and cancellous bones in two-layer bones are needed. MDPI 2022-02-28 /pmc/articles/PMC8910567/ /pubmed/35269791 http://dx.doi.org/10.3390/ijms23052647 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Seo, Yong-Ho
Hwang, Su-Hyun
Kim, Yu-Na
Kim, Hyung-Joon
Bae, Eun-Bin
Huh, Jung-Bo
Bone Reconstruction Using Two-Layer Porcine-Derived Bone Scaffold Composed of Cortical and Cancellous Bones in a Rabbit Calvarial Defect Model
title Bone Reconstruction Using Two-Layer Porcine-Derived Bone Scaffold Composed of Cortical and Cancellous Bones in a Rabbit Calvarial Defect Model
title_full Bone Reconstruction Using Two-Layer Porcine-Derived Bone Scaffold Composed of Cortical and Cancellous Bones in a Rabbit Calvarial Defect Model
title_fullStr Bone Reconstruction Using Two-Layer Porcine-Derived Bone Scaffold Composed of Cortical and Cancellous Bones in a Rabbit Calvarial Defect Model
title_full_unstemmed Bone Reconstruction Using Two-Layer Porcine-Derived Bone Scaffold Composed of Cortical and Cancellous Bones in a Rabbit Calvarial Defect Model
title_short Bone Reconstruction Using Two-Layer Porcine-Derived Bone Scaffold Composed of Cortical and Cancellous Bones in a Rabbit Calvarial Defect Model
title_sort bone reconstruction using two-layer porcine-derived bone scaffold composed of cortical and cancellous bones in a rabbit calvarial defect model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910567/
https://www.ncbi.nlm.nih.gov/pubmed/35269791
http://dx.doi.org/10.3390/ijms23052647
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