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The Role of Seminal Oxidative Stress Scavenging System in the Pathogenesis of Sperm DNA Damage in Men Exposed and Not Exposed to Genital Heat Stress

Responding to the need for the verification of some experimental animal studies showing the involvement of oxidative stress in germ cell damage in the heat-induced testis, we investigated the possibility of a direct relationship between seminal oxidative stress markers (total antioxidant capacity, c...

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Autores principales: Fraczek, Monika, Lewandowska, Angelika, Budzinska, Marta, Kamieniczna, Marzena, Wojnar, Lukasz, Gill, Kamil, Piasecka, Malgorzata, Kups, Michal, Havrylyuk, Anna, Chopyak, Valentina, Nakonechnyy, Jozef, Nakonechnyy, Andrij, Kurpisz, Maciej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910598/
https://www.ncbi.nlm.nih.gov/pubmed/35270405
http://dx.doi.org/10.3390/ijerph19052713
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author Fraczek, Monika
Lewandowska, Angelika
Budzinska, Marta
Kamieniczna, Marzena
Wojnar, Lukasz
Gill, Kamil
Piasecka, Malgorzata
Kups, Michal
Havrylyuk, Anna
Chopyak, Valentina
Nakonechnyy, Jozef
Nakonechnyy, Andrij
Kurpisz, Maciej
author_facet Fraczek, Monika
Lewandowska, Angelika
Budzinska, Marta
Kamieniczna, Marzena
Wojnar, Lukasz
Gill, Kamil
Piasecka, Malgorzata
Kups, Michal
Havrylyuk, Anna
Chopyak, Valentina
Nakonechnyy, Jozef
Nakonechnyy, Andrij
Kurpisz, Maciej
author_sort Fraczek, Monika
collection PubMed
description Responding to the need for the verification of some experimental animal studies showing the involvement of oxidative stress in germ cell damage in the heat-induced testis, we investigated the possibility of a direct relationship between seminal oxidative stress markers (total antioxidant capacity, catalase activity, superoxide dismutase activity, and malondialdehyde concentration) and ejaculated sperm chromatin/DNA integrity (DNA fragmentation and chromatin condensation abnormalities) in distinct groups of men exposed and not exposed to prolonged scrotal hyperthermia. A statistical increase in the proportion of sperm with DNA fragmentation was observed in all the studied subgroups compared to the fertile men. In turn, the groups subjected to heat stress as professional drivers or infertile men with varicocele presented greater disturbances in the oxidative stress scavenging system than men not exposed to genital heat stress. Based on the comparative analysis of the studied parameters, we can conclude that alterations in the seminal oxidative stress scavenging system are directly engaged in the pathogenesis of ejaculated sperm DNA damage regardless of the intensity of the impact of thermal insult. To the best of our knowledge, this study, for the first time, revealed the co-existence of oxidative stress and sperm DNA damage in the semen of professional drivers.
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spelling pubmed-89105982022-03-11 The Role of Seminal Oxidative Stress Scavenging System in the Pathogenesis of Sperm DNA Damage in Men Exposed and Not Exposed to Genital Heat Stress Fraczek, Monika Lewandowska, Angelika Budzinska, Marta Kamieniczna, Marzena Wojnar, Lukasz Gill, Kamil Piasecka, Malgorzata Kups, Michal Havrylyuk, Anna Chopyak, Valentina Nakonechnyy, Jozef Nakonechnyy, Andrij Kurpisz, Maciej Int J Environ Res Public Health Article Responding to the need for the verification of some experimental animal studies showing the involvement of oxidative stress in germ cell damage in the heat-induced testis, we investigated the possibility of a direct relationship between seminal oxidative stress markers (total antioxidant capacity, catalase activity, superoxide dismutase activity, and malondialdehyde concentration) and ejaculated sperm chromatin/DNA integrity (DNA fragmentation and chromatin condensation abnormalities) in distinct groups of men exposed and not exposed to prolonged scrotal hyperthermia. A statistical increase in the proportion of sperm with DNA fragmentation was observed in all the studied subgroups compared to the fertile men. In turn, the groups subjected to heat stress as professional drivers or infertile men with varicocele presented greater disturbances in the oxidative stress scavenging system than men not exposed to genital heat stress. Based on the comparative analysis of the studied parameters, we can conclude that alterations in the seminal oxidative stress scavenging system are directly engaged in the pathogenesis of ejaculated sperm DNA damage regardless of the intensity of the impact of thermal insult. To the best of our knowledge, this study, for the first time, revealed the co-existence of oxidative stress and sperm DNA damage in the semen of professional drivers. MDPI 2022-02-25 /pmc/articles/PMC8910598/ /pubmed/35270405 http://dx.doi.org/10.3390/ijerph19052713 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fraczek, Monika
Lewandowska, Angelika
Budzinska, Marta
Kamieniczna, Marzena
Wojnar, Lukasz
Gill, Kamil
Piasecka, Malgorzata
Kups, Michal
Havrylyuk, Anna
Chopyak, Valentina
Nakonechnyy, Jozef
Nakonechnyy, Andrij
Kurpisz, Maciej
The Role of Seminal Oxidative Stress Scavenging System in the Pathogenesis of Sperm DNA Damage in Men Exposed and Not Exposed to Genital Heat Stress
title The Role of Seminal Oxidative Stress Scavenging System in the Pathogenesis of Sperm DNA Damage in Men Exposed and Not Exposed to Genital Heat Stress
title_full The Role of Seminal Oxidative Stress Scavenging System in the Pathogenesis of Sperm DNA Damage in Men Exposed and Not Exposed to Genital Heat Stress
title_fullStr The Role of Seminal Oxidative Stress Scavenging System in the Pathogenesis of Sperm DNA Damage in Men Exposed and Not Exposed to Genital Heat Stress
title_full_unstemmed The Role of Seminal Oxidative Stress Scavenging System in the Pathogenesis of Sperm DNA Damage in Men Exposed and Not Exposed to Genital Heat Stress
title_short The Role of Seminal Oxidative Stress Scavenging System in the Pathogenesis of Sperm DNA Damage in Men Exposed and Not Exposed to Genital Heat Stress
title_sort role of seminal oxidative stress scavenging system in the pathogenesis of sperm dna damage in men exposed and not exposed to genital heat stress
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910598/
https://www.ncbi.nlm.nih.gov/pubmed/35270405
http://dx.doi.org/10.3390/ijerph19052713
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