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Molecular Mechanisms and Biomarkers Associated with Chemotherapy-Induced AKI

Acute kidney injury (AKI) is a life-threatening condition characterized by a rapid and transient decrease in kidney function. AKI is part of an array of conditions collectively defined as acute kidney diseases (AKD). In AKD, persistent kidney damage and dysfunction lead to chronic kidney disease (CK...

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Autores principales: De Chiara, Letizia, Lugli, Gianmarco, Villa, Gianluca, Raglianti, Valentina, Husain-Syed, Faeq, Ravaglia, Fiammetta, Romagnani, Paola, Lazzeri, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910619/
https://www.ncbi.nlm.nih.gov/pubmed/35269781
http://dx.doi.org/10.3390/ijms23052638
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author De Chiara, Letizia
Lugli, Gianmarco
Villa, Gianluca
Raglianti, Valentina
Husain-Syed, Faeq
Ravaglia, Fiammetta
Romagnani, Paola
Lazzeri, Elena
author_facet De Chiara, Letizia
Lugli, Gianmarco
Villa, Gianluca
Raglianti, Valentina
Husain-Syed, Faeq
Ravaglia, Fiammetta
Romagnani, Paola
Lazzeri, Elena
author_sort De Chiara, Letizia
collection PubMed
description Acute kidney injury (AKI) is a life-threatening condition characterized by a rapid and transient decrease in kidney function. AKI is part of an array of conditions collectively defined as acute kidney diseases (AKD). In AKD, persistent kidney damage and dysfunction lead to chronic kidney disease (CKD) over time. A variety of insults can trigger AKI; however, chemotherapy-associated nephrotoxicity is increasingly recognized as a significant side effect of chemotherapy. New biomarkers are urgently needed to identify patients at high risk of developing chemotherapy-associated nephrotoxicity and subsequent AKI. However, a lack of understanding of cellular mechanisms that trigger chemotherapy-related nephrotoxicity has hindered the identification of effective biomarkers to date. In this review, we aim to (1) describe the known and potential mechanisms related to chemotherapy-induced AKI; (2) summarize the available biomarkers for early AKI detection, and (3) raise awareness of chemotherapy-induced AKI.
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spelling pubmed-89106192022-03-11 Molecular Mechanisms and Biomarkers Associated with Chemotherapy-Induced AKI De Chiara, Letizia Lugli, Gianmarco Villa, Gianluca Raglianti, Valentina Husain-Syed, Faeq Ravaglia, Fiammetta Romagnani, Paola Lazzeri, Elena Int J Mol Sci Review Acute kidney injury (AKI) is a life-threatening condition characterized by a rapid and transient decrease in kidney function. AKI is part of an array of conditions collectively defined as acute kidney diseases (AKD). In AKD, persistent kidney damage and dysfunction lead to chronic kidney disease (CKD) over time. A variety of insults can trigger AKI; however, chemotherapy-associated nephrotoxicity is increasingly recognized as a significant side effect of chemotherapy. New biomarkers are urgently needed to identify patients at high risk of developing chemotherapy-associated nephrotoxicity and subsequent AKI. However, a lack of understanding of cellular mechanisms that trigger chemotherapy-related nephrotoxicity has hindered the identification of effective biomarkers to date. In this review, we aim to (1) describe the known and potential mechanisms related to chemotherapy-induced AKI; (2) summarize the available biomarkers for early AKI detection, and (3) raise awareness of chemotherapy-induced AKI. MDPI 2022-02-27 /pmc/articles/PMC8910619/ /pubmed/35269781 http://dx.doi.org/10.3390/ijms23052638 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
De Chiara, Letizia
Lugli, Gianmarco
Villa, Gianluca
Raglianti, Valentina
Husain-Syed, Faeq
Ravaglia, Fiammetta
Romagnani, Paola
Lazzeri, Elena
Molecular Mechanisms and Biomarkers Associated with Chemotherapy-Induced AKI
title Molecular Mechanisms and Biomarkers Associated with Chemotherapy-Induced AKI
title_full Molecular Mechanisms and Biomarkers Associated with Chemotherapy-Induced AKI
title_fullStr Molecular Mechanisms and Biomarkers Associated with Chemotherapy-Induced AKI
title_full_unstemmed Molecular Mechanisms and Biomarkers Associated with Chemotherapy-Induced AKI
title_short Molecular Mechanisms and Biomarkers Associated with Chemotherapy-Induced AKI
title_sort molecular mechanisms and biomarkers associated with chemotherapy-induced aki
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910619/
https://www.ncbi.nlm.nih.gov/pubmed/35269781
http://dx.doi.org/10.3390/ijms23052638
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