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Bone Fragility in Gastrointestinal Disorders

Osteoporosis is a common systemic disease of the skeleton, characterized by compromised bone mass and strength, consequently leading to an increased risk of fragility fractures. In women, the disease mainly occurs due to the menopausal fall in estrogen levels, leading to an imbalance between bone re...

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Autores principales: Merlotti, Daniela, Mingiano, Christian, Valenti, Roberto, Cavati, Guido, Calabrese, Marco, Pirrotta, Filippo, Bianciardi, Simone, Palazzuoli, Alberto, Gennari, Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910640/
https://www.ncbi.nlm.nih.gov/pubmed/35269854
http://dx.doi.org/10.3390/ijms23052713
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author Merlotti, Daniela
Mingiano, Christian
Valenti, Roberto
Cavati, Guido
Calabrese, Marco
Pirrotta, Filippo
Bianciardi, Simone
Palazzuoli, Alberto
Gennari, Luigi
author_facet Merlotti, Daniela
Mingiano, Christian
Valenti, Roberto
Cavati, Guido
Calabrese, Marco
Pirrotta, Filippo
Bianciardi, Simone
Palazzuoli, Alberto
Gennari, Luigi
author_sort Merlotti, Daniela
collection PubMed
description Osteoporosis is a common systemic disease of the skeleton, characterized by compromised bone mass and strength, consequently leading to an increased risk of fragility fractures. In women, the disease mainly occurs due to the menopausal fall in estrogen levels, leading to an imbalance between bone resorption and bone formation and, consequently, to bone loss and bone fragility. Moreover, osteoporosis may affect men and may occur as a sequela to different diseases or even to their treatments. Despite their wide prevalence in the general population, the skeletal implications of many gastrointestinal diseases have been poorly investigated and their potential contribution to bone fragility is often underestimated in clinical practice. However, proper functioning of the gastrointestinal system appears essential for the skeleton, allowing correct absorption of calcium, vitamins, or other nutrients relevant to bone, preserving the gastrointestinal barrier function, and maintaining an optimal endocrine-metabolic balance, so that it is very likely that most chronic diseases of the gastrointestinal tract, and even gastrointestinal dysbiosis, may have profound implications for bone health. In this manuscript, we provide an updated and critical revision of the role of major gastrointestinal disorders in the pathogenesis of osteoporosis and fragility fractures.
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spelling pubmed-89106402022-03-11 Bone Fragility in Gastrointestinal Disorders Merlotti, Daniela Mingiano, Christian Valenti, Roberto Cavati, Guido Calabrese, Marco Pirrotta, Filippo Bianciardi, Simone Palazzuoli, Alberto Gennari, Luigi Int J Mol Sci Review Osteoporosis is a common systemic disease of the skeleton, characterized by compromised bone mass and strength, consequently leading to an increased risk of fragility fractures. In women, the disease mainly occurs due to the menopausal fall in estrogen levels, leading to an imbalance between bone resorption and bone formation and, consequently, to bone loss and bone fragility. Moreover, osteoporosis may affect men and may occur as a sequela to different diseases or even to their treatments. Despite their wide prevalence in the general population, the skeletal implications of many gastrointestinal diseases have been poorly investigated and their potential contribution to bone fragility is often underestimated in clinical practice. However, proper functioning of the gastrointestinal system appears essential for the skeleton, allowing correct absorption of calcium, vitamins, or other nutrients relevant to bone, preserving the gastrointestinal barrier function, and maintaining an optimal endocrine-metabolic balance, so that it is very likely that most chronic diseases of the gastrointestinal tract, and even gastrointestinal dysbiosis, may have profound implications for bone health. In this manuscript, we provide an updated and critical revision of the role of major gastrointestinal disorders in the pathogenesis of osteoporosis and fragility fractures. MDPI 2022-02-28 /pmc/articles/PMC8910640/ /pubmed/35269854 http://dx.doi.org/10.3390/ijms23052713 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Merlotti, Daniela
Mingiano, Christian
Valenti, Roberto
Cavati, Guido
Calabrese, Marco
Pirrotta, Filippo
Bianciardi, Simone
Palazzuoli, Alberto
Gennari, Luigi
Bone Fragility in Gastrointestinal Disorders
title Bone Fragility in Gastrointestinal Disorders
title_full Bone Fragility in Gastrointestinal Disorders
title_fullStr Bone Fragility in Gastrointestinal Disorders
title_full_unstemmed Bone Fragility in Gastrointestinal Disorders
title_short Bone Fragility in Gastrointestinal Disorders
title_sort bone fragility in gastrointestinal disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910640/
https://www.ncbi.nlm.nih.gov/pubmed/35269854
http://dx.doi.org/10.3390/ijms23052713
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