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Prognosis of Coronary Artery Bypass Grafting in Preschool-Aged Patients with Myocardial Ischemia Due to Giant Aneurysm of Kawasaki Disease

Coronary artery bypass grafting (CABG) for severe cardiac sequelae of Kawasaki disease (KD) complicated by myocardial ischemia is feasible even in childhood. However, no report has summarized the prognosis of CABG in preschool-aged children. Therefore, we evaluated the outcomes of seven preschool-ag...

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Autores principales: Watanabe, Makoto, Fukazawa, Ryuji, Kamisago, Mitsuhiro, Ohkubo, Takashi, Abe, Masanori, Ochi, Masami, Nitta, Takashi, Ishii, Yohsuke, Ogawa, Shunichi, Itoh, Yasuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910851/
https://www.ncbi.nlm.nih.gov/pubmed/35268512
http://dx.doi.org/10.3390/jcm11051421
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author Watanabe, Makoto
Fukazawa, Ryuji
Kamisago, Mitsuhiro
Ohkubo, Takashi
Abe, Masanori
Ochi, Masami
Nitta, Takashi
Ishii, Yohsuke
Ogawa, Shunichi
Itoh, Yasuhiko
author_facet Watanabe, Makoto
Fukazawa, Ryuji
Kamisago, Mitsuhiro
Ohkubo, Takashi
Abe, Masanori
Ochi, Masami
Nitta, Takashi
Ishii, Yohsuke
Ogawa, Shunichi
Itoh, Yasuhiko
author_sort Watanabe, Makoto
collection PubMed
description Coronary artery bypass grafting (CABG) for severe cardiac sequelae of Kawasaki disease (KD) complicated by myocardial ischemia is feasible even in childhood. However, no report has summarized the prognosis of CABG in preschool-aged children. Therefore, we evaluated the outcomes of seven preschool-aged children who underwent CABG for the cardiac sequelae of KD in our hospital. The median age at KD onset and CABG was 36 and 59 months, respectively. The median period from KD onset to CABG was 12 months. The median post-operative observation period was 108 months. CABG between the left internal thoracic artery and left anterior descending artery was performed in all patients. In all patients, postoperative cardiac catheter examination revealed good graft patency and no anastomotic stenosis. Further, pre-operative abnormality of coronary flow reserve returned to normal after CABG. Currently, only one patient is taking warfarin. Regarding school–life management, no patient has exercise limitations, except for one patient who had acute myocardial infarction before CABG. Further, the risk of graft stenosis or occlusion was evaluated in the included patients. However, no accidents have been reported to date, and myocardial ischemia and school–life management have improved. Thus, CABG is an effective treatment in preschool-aged children.
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spelling pubmed-89108512022-03-11 Prognosis of Coronary Artery Bypass Grafting in Preschool-Aged Patients with Myocardial Ischemia Due to Giant Aneurysm of Kawasaki Disease Watanabe, Makoto Fukazawa, Ryuji Kamisago, Mitsuhiro Ohkubo, Takashi Abe, Masanori Ochi, Masami Nitta, Takashi Ishii, Yohsuke Ogawa, Shunichi Itoh, Yasuhiko J Clin Med Article Coronary artery bypass grafting (CABG) for severe cardiac sequelae of Kawasaki disease (KD) complicated by myocardial ischemia is feasible even in childhood. However, no report has summarized the prognosis of CABG in preschool-aged children. Therefore, we evaluated the outcomes of seven preschool-aged children who underwent CABG for the cardiac sequelae of KD in our hospital. The median age at KD onset and CABG was 36 and 59 months, respectively. The median period from KD onset to CABG was 12 months. The median post-operative observation period was 108 months. CABG between the left internal thoracic artery and left anterior descending artery was performed in all patients. In all patients, postoperative cardiac catheter examination revealed good graft patency and no anastomotic stenosis. Further, pre-operative abnormality of coronary flow reserve returned to normal after CABG. Currently, only one patient is taking warfarin. Regarding school–life management, no patient has exercise limitations, except for one patient who had acute myocardial infarction before CABG. Further, the risk of graft stenosis or occlusion was evaluated in the included patients. However, no accidents have been reported to date, and myocardial ischemia and school–life management have improved. Thus, CABG is an effective treatment in preschool-aged children. MDPI 2022-03-04 /pmc/articles/PMC8910851/ /pubmed/35268512 http://dx.doi.org/10.3390/jcm11051421 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Watanabe, Makoto
Fukazawa, Ryuji
Kamisago, Mitsuhiro
Ohkubo, Takashi
Abe, Masanori
Ochi, Masami
Nitta, Takashi
Ishii, Yohsuke
Ogawa, Shunichi
Itoh, Yasuhiko
Prognosis of Coronary Artery Bypass Grafting in Preschool-Aged Patients with Myocardial Ischemia Due to Giant Aneurysm of Kawasaki Disease
title Prognosis of Coronary Artery Bypass Grafting in Preschool-Aged Patients with Myocardial Ischemia Due to Giant Aneurysm of Kawasaki Disease
title_full Prognosis of Coronary Artery Bypass Grafting in Preschool-Aged Patients with Myocardial Ischemia Due to Giant Aneurysm of Kawasaki Disease
title_fullStr Prognosis of Coronary Artery Bypass Grafting in Preschool-Aged Patients with Myocardial Ischemia Due to Giant Aneurysm of Kawasaki Disease
title_full_unstemmed Prognosis of Coronary Artery Bypass Grafting in Preschool-Aged Patients with Myocardial Ischemia Due to Giant Aneurysm of Kawasaki Disease
title_short Prognosis of Coronary Artery Bypass Grafting in Preschool-Aged Patients with Myocardial Ischemia Due to Giant Aneurysm of Kawasaki Disease
title_sort prognosis of coronary artery bypass grafting in preschool-aged patients with myocardial ischemia due to giant aneurysm of kawasaki disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910851/
https://www.ncbi.nlm.nih.gov/pubmed/35268512
http://dx.doi.org/10.3390/jcm11051421
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