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IGNITE Status Epilepticus Survey: A Nationwide Interrogation about the Current Management of Status Epilepticus in Germany

We aimed to evaluate the current management of status epilepticus (SE) in intensive care units (ICUs) in Germany, depending on the different hospital levels of care and the ICU specialty. We performed a nationwide web-based anonymized survey, including all German ICUs registered with the German Soci...

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Autores principales: Kowoll, Christina M., Klein, Matthias, Salih, Farid, Fink, Gereon R., Stetefeld, Henning R., Onur, Oezguer A., Malter, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910893/
https://www.ncbi.nlm.nih.gov/pubmed/35268262
http://dx.doi.org/10.3390/jcm11051171
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author Kowoll, Christina M.
Klein, Matthias
Salih, Farid
Fink, Gereon R.
Stetefeld, Henning R.
Onur, Oezguer A.
Malter, Michael P.
author_facet Kowoll, Christina M.
Klein, Matthias
Salih, Farid
Fink, Gereon R.
Stetefeld, Henning R.
Onur, Oezguer A.
Malter, Michael P.
author_sort Kowoll, Christina M.
collection PubMed
description We aimed to evaluate the current management of status epilepticus (SE) in intensive care units (ICUs) in Germany, depending on the different hospital levels of care and the ICU specialty. We performed a nationwide web-based anonymized survey, including all German ICUs registered with the German Society for Neurointensive and Emergency Care (Deutsche Gesellschaft für Neurointensiv- und Notfallmedizin; DGNI). The response rate was 83/232 (36%). Continuous EEG monitoring (cEEG) was available in 86% of ICUs. Regular written cEEG reports were obtained in only 50%. Drug management was homogeneous with a general consensus regarding substance order: benzodiazepines—anticonvulsants—sedatives. Thereunder first choice substances were lorazepam (90%), levetiracetam (91%), and propofol (73%). Data suggest that network structures for super-refractory SE are not permeable, as 75% did not transfer SE patients. Our survey provides “real world data” concerning the current management of SE in Germany. Uniform standards in the implementation of cEEG could help further improve the overall quality. Initial therapy management is standardized. For super-refractory SE, a concentration of highly specialized centers establishing network structures analogous to neurovascular diseases seems desirable to apply rescue therapies with low evidence carefully, ideally collecting data on this rare condition in registries and clinical trials.
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spelling pubmed-89108932022-03-11 IGNITE Status Epilepticus Survey: A Nationwide Interrogation about the Current Management of Status Epilepticus in Germany Kowoll, Christina M. Klein, Matthias Salih, Farid Fink, Gereon R. Stetefeld, Henning R. Onur, Oezguer A. Malter, Michael P. J Clin Med Article We aimed to evaluate the current management of status epilepticus (SE) in intensive care units (ICUs) in Germany, depending on the different hospital levels of care and the ICU specialty. We performed a nationwide web-based anonymized survey, including all German ICUs registered with the German Society for Neurointensive and Emergency Care (Deutsche Gesellschaft für Neurointensiv- und Notfallmedizin; DGNI). The response rate was 83/232 (36%). Continuous EEG monitoring (cEEG) was available in 86% of ICUs. Regular written cEEG reports were obtained in only 50%. Drug management was homogeneous with a general consensus regarding substance order: benzodiazepines—anticonvulsants—sedatives. Thereunder first choice substances were lorazepam (90%), levetiracetam (91%), and propofol (73%). Data suggest that network structures for super-refractory SE are not permeable, as 75% did not transfer SE patients. Our survey provides “real world data” concerning the current management of SE in Germany. Uniform standards in the implementation of cEEG could help further improve the overall quality. Initial therapy management is standardized. For super-refractory SE, a concentration of highly specialized centers establishing network structures analogous to neurovascular diseases seems desirable to apply rescue therapies with low evidence carefully, ideally collecting data on this rare condition in registries and clinical trials. MDPI 2022-02-22 /pmc/articles/PMC8910893/ /pubmed/35268262 http://dx.doi.org/10.3390/jcm11051171 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kowoll, Christina M.
Klein, Matthias
Salih, Farid
Fink, Gereon R.
Stetefeld, Henning R.
Onur, Oezguer A.
Malter, Michael P.
IGNITE Status Epilepticus Survey: A Nationwide Interrogation about the Current Management of Status Epilepticus in Germany
title IGNITE Status Epilepticus Survey: A Nationwide Interrogation about the Current Management of Status Epilepticus in Germany
title_full IGNITE Status Epilepticus Survey: A Nationwide Interrogation about the Current Management of Status Epilepticus in Germany
title_fullStr IGNITE Status Epilepticus Survey: A Nationwide Interrogation about the Current Management of Status Epilepticus in Germany
title_full_unstemmed IGNITE Status Epilepticus Survey: A Nationwide Interrogation about the Current Management of Status Epilepticus in Germany
title_short IGNITE Status Epilepticus Survey: A Nationwide Interrogation about the Current Management of Status Epilepticus in Germany
title_sort ignite status epilepticus survey: a nationwide interrogation about the current management of status epilepticus in germany
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910893/
https://www.ncbi.nlm.nih.gov/pubmed/35268262
http://dx.doi.org/10.3390/jcm11051171
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