Cargando…

Procalcitonin to Predict Severity of Acute Cholangitis and Need for Urgent Biliary Decompression: Systematic Scoping Review

Serum procalcitonin (PCT) has been reported as a potential biomarker to predict the severity of acute cholangitis (AC) or the need for urgent biliary decompression. This study aimed to identify and summarize the existing research about serum PCT and the severity of AC, and to find gaps towards which...

Descripción completa

Detalles Bibliográficos
Autores principales: Silangcruz, Krixie, Nishimura, Yoshito, Czech, Torrey, Kimura, Nobuhiko, Yess, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910914/
https://www.ncbi.nlm.nih.gov/pubmed/35268246
http://dx.doi.org/10.3390/jcm11051155
_version_ 1784666615615324160
author Silangcruz, Krixie
Nishimura, Yoshito
Czech, Torrey
Kimura, Nobuhiko
Yess, James
author_facet Silangcruz, Krixie
Nishimura, Yoshito
Czech, Torrey
Kimura, Nobuhiko
Yess, James
author_sort Silangcruz, Krixie
collection PubMed
description Serum procalcitonin (PCT) has been reported as a potential biomarker to predict the severity of acute cholangitis (AC) or the need for urgent biliary decompression. This study aimed to identify and summarize the existing research about serum PCT and the severity of AC, and to find gaps towards which future studies can be targeted. Following the PRISMA extension for scoping reviews, MEDLINE, EMBASE, and Google Scholar were searched for all peer-reviewed articles with relevant keywords including “cholangitis” and “procalcitonin” from their inception to 13 July 2021. We identified six studies. All the studies employed a case-control design and aimed to evaluate the usefulness of serum PCT to predict the severity of AC with key identified outcomes. While the potential cut-off values of serum PCT for severe AC ranged from 1.8–3.1 ng/mL, studies used different severity criteria and the definition of urgent biliary decompression. No studies proposed cut-off PCT values for the need for urgent biliary decompression. This scoping review identified the current level of evidence regarding the usefulness of serum PCT in assessing the severity of AC. Further clinical research is warranted with a focus on standardized outcome measures employing prospective or experimental designs.
format Online
Article
Text
id pubmed-8910914
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-89109142022-03-11 Procalcitonin to Predict Severity of Acute Cholangitis and Need for Urgent Biliary Decompression: Systematic Scoping Review Silangcruz, Krixie Nishimura, Yoshito Czech, Torrey Kimura, Nobuhiko Yess, James J Clin Med Review Serum procalcitonin (PCT) has been reported as a potential biomarker to predict the severity of acute cholangitis (AC) or the need for urgent biliary decompression. This study aimed to identify and summarize the existing research about serum PCT and the severity of AC, and to find gaps towards which future studies can be targeted. Following the PRISMA extension for scoping reviews, MEDLINE, EMBASE, and Google Scholar were searched for all peer-reviewed articles with relevant keywords including “cholangitis” and “procalcitonin” from their inception to 13 July 2021. We identified six studies. All the studies employed a case-control design and aimed to evaluate the usefulness of serum PCT to predict the severity of AC with key identified outcomes. While the potential cut-off values of serum PCT for severe AC ranged from 1.8–3.1 ng/mL, studies used different severity criteria and the definition of urgent biliary decompression. No studies proposed cut-off PCT values for the need for urgent biliary decompression. This scoping review identified the current level of evidence regarding the usefulness of serum PCT in assessing the severity of AC. Further clinical research is warranted with a focus on standardized outcome measures employing prospective or experimental designs. MDPI 2022-02-22 /pmc/articles/PMC8910914/ /pubmed/35268246 http://dx.doi.org/10.3390/jcm11051155 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Silangcruz, Krixie
Nishimura, Yoshito
Czech, Torrey
Kimura, Nobuhiko
Yess, James
Procalcitonin to Predict Severity of Acute Cholangitis and Need for Urgent Biliary Decompression: Systematic Scoping Review
title Procalcitonin to Predict Severity of Acute Cholangitis and Need for Urgent Biliary Decompression: Systematic Scoping Review
title_full Procalcitonin to Predict Severity of Acute Cholangitis and Need for Urgent Biliary Decompression: Systematic Scoping Review
title_fullStr Procalcitonin to Predict Severity of Acute Cholangitis and Need for Urgent Biliary Decompression: Systematic Scoping Review
title_full_unstemmed Procalcitonin to Predict Severity of Acute Cholangitis and Need for Urgent Biliary Decompression: Systematic Scoping Review
title_short Procalcitonin to Predict Severity of Acute Cholangitis and Need for Urgent Biliary Decompression: Systematic Scoping Review
title_sort procalcitonin to predict severity of acute cholangitis and need for urgent biliary decompression: systematic scoping review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910914/
https://www.ncbi.nlm.nih.gov/pubmed/35268246
http://dx.doi.org/10.3390/jcm11051155
work_keys_str_mv AT silangcruzkrixie procalcitonintopredictseverityofacutecholangitisandneedforurgentbiliarydecompressionsystematicscopingreview
AT nishimurayoshito procalcitonintopredictseverityofacutecholangitisandneedforurgentbiliarydecompressionsystematicscopingreview
AT czechtorrey procalcitonintopredictseverityofacutecholangitisandneedforurgentbiliarydecompressionsystematicscopingreview
AT kimuranobuhiko procalcitonintopredictseverityofacutecholangitisandneedforurgentbiliarydecompressionsystematicscopingreview
AT yessjames procalcitonintopredictseverityofacutecholangitisandneedforurgentbiliarydecompressionsystematicscopingreview