Cargando…

Decreased Serum Levels of SIRT1 and SIRT3 Correlate with Severity of Skin and Lung Fibrosis and Peripheral Microvasculopathy in Systemic Sclerosis

Systemic sclerosis (SSc, scleroderma) is a severe autoimmune connective tissue disease characterized by widespread peripheral microvasculopathy, and progressive cutaneous and visceral fibrosis, leading to significant organ dysfunction. Sirtuins (SIRTs) are a family of NAD-dependent protein deacetyla...

Descripción completa

Detalles Bibliográficos
Autores principales:	Manetti, Mirko, Rosa, Irene, Fioretto, Bianca Saveria, Matucci-Cerinic, Marco, Romano, Eloisa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910971/ https://www.ncbi.nlm.nih.gov/pubmed/35268452 http://dx.doi.org/10.3390/jcm11051362

Ejemplares similares

Circulating Neurovascular Guidance Molecules and Their Relationship with Peripheral Microvascular Impairment in Systemic Sclerosis
por: Romano, Eloisa, et al.
Publicado: (2022)

Increased Circulating Soluble Junctional Adhesion Molecules in Systemic Sclerosis: Association with Peripheral Microvascular Impairment
por: Romano, Eloisa, et al.
Publicado: (2022)

Lymphatic Endothelial-to-Myofibroblast Transition: A Potential New Mechanism Underlying Skin Fibrosis in Systemic Sclerosis
por: Rosa, Irene, et al.
Publicado: (2023)

Current Trends in Vascular Biomarkers for Systemic Sclerosis: A Narrative Review
por: Fioretto, Bianca Saveria, et al.
Publicado: (2023)

Adipose-derived stem cells: Pathophysiologic implications vs therapeutic potential in systemic sclerosis
por: Rosa, Irene, et al.
Publicado: (2021)

New Insights into Profibrotic Myofibroblast Formation in Systemic Sclerosis: When the Vascular Wall Becomes the Enemy
por: Romano, Eloisa, et al.
Publicado: (2021)

Scleroderma-like Impairment in the Network of Telocytes/CD34(+) Stromal Cells in the Experimental Mouse Model of Bleomycin-Induced Dermal Fibrosis
por: Rosa, Irene, et al.
Publicado: (2021)

The contribution of epigenetics to the pathogenesis and gender dimorphism of systemic sclerosis: a comprehensive overview
por: Fioretto, Bianca Saveria, et al.
Publicado: (2020)

Angiogenic T cell expansion correlates with severity of peripheral vascular damage in systemic sclerosis
por: Manetti, Mirko, et al.
Publicado: (2017)

A Two-Step Immunomagnetic Microbead-Based Method for the Isolation of Human Primary Skin Telocytes/CD34+ Stromal Cells
por: Romano, Eloisa, et al.
Publicado: (2020)

Systemic Sclerosis Serum Steers the Differentiation of Adipose-Derived Stem Cells Toward Profibrotic Myofibroblasts: Pathophysiologic Implications
por: Manetti, Mirko, et al.
Publicado: (2019)

Extracellular Lactic Acidosis of the Tumor Microenvironment Drives Adipocyte-to-Myofibroblast Transition Fueling the Generation of Cancer-Associated Fibroblasts
por: Andreucci, Elena, et al.
Publicado: (2023)

Systemic Sclerosis Serum Significantly Impairs the Multi-Step Lymphangiogenic Process: In Vitro Evidence
por: Manetti, Mirko, et al.
Publicado: (2019)

A loss of telocytes accompanies fibrosis of multiple organs in systemic sclerosis
por: Manetti, Mirko, et al.
Publicado: (2014)

The Soluble Guanylate Cyclase Stimulator BAY 41-2272 Attenuates Transforming Growth Factor β1-Induced Myofibroblast Differentiation of Human Corneal Keratocytes
por: Rosa, Irene, et al.
Publicado: (2022)

Decreased expression of the endothelial cell-derived factor EGFL7 in systemic sclerosis: potential contribution to impaired angiogenesis and vasculogenesis
por: Manetti, Mirko, et al.
Publicado: (2013)

The crowded crossroad to angiogenesis in systemic sclerosis: where is the key to the problem?
por: Manetti, Mirko, et al.
Publicado: (2016)

Impairment in the telocyte/CD34(+) stromal cell network in human rheumatoid arthritis synovium
por: Rosa, Irene, et al.
Publicado: (2020)

Advances in Systemic Sclerosis: From Pathogenetic Pathways toward Novel Therapeutic Targets
por: Romano, Eloisa, et al.
Publicado: (2023)

Proangiogenic effects of soluble α-Klotho on systemic sclerosis dermal microvascular endothelial cells
por: Mazzotta, Celestina, et al.
Publicado: (2017)

Angiotensin II type 2 receptor (AT2R) as a novel modulator of inflammation in rheumatoid arthritis synovium
por: Terenzi, Riccardo, et al.
Publicado: (2017)

Mechanisms in the loss of capillaries in systemic sclerosis: angiogenesis versus vasculogenesis
por: Manetti, Mirko, et al.
Publicado: (2010)

Evidence for progressive reduction and loss of telocytes in the dermal cellular network of systemic sclerosis
por: Manetti, Mirko, et al.
Publicado: (2013)

Plexin-D1/Semaphorin 3E pathway may contribute to dysregulation of vascular tone control and defective angiogenesis in systemic sclerosis
por: Mazzotta, Celestina, et al.
Publicado: (2015)

TNF-α/TNF-R System May Represent a Crucial Mediator of Proliferative Synovitis in Hemophilia A
por: Manetti, Mirko, et al.
Publicado: (2019)

SIRT3 is attenuated in systemic sclerosis skin and lungs, and its pharmacologic activation mitigates organ fibrosis
por: Akamata, Kaname, et al.
Publicado: (2016)

Pathophysiology of Hemophilic Arthropathy
por: Melchiorre, Daniela, et al.
Publicado: (2017)

Abnormal expression of SIRTs in psoriasis: Decreased expression of SIRT 1-5 and increased expression of SIRT 6 and 7
por: Fan, Xiaojing, et al.
Publicado: (2019)

Can calcium dobesilate be used safely for peripheral microvasculopathies that require neoangiogenesis?
por: Demirtas, Sinan, et al.
Publicado: (2013)

Decreased SIRT1 expression in the peripheral blood of patients with Graves’ disease
por: Yin, Qinglei, et al.
Publicado: (2020)

Anti-Fas IgM monoclonal antibody (anti-Fas mAb) effect on haemophilic arthropathy (HA) synoviocytes
por: Guiducci, Serena, et al.
Publicado: (2012)

Inflammation and Microvasculopathy in Renal Ischemia Reperfusion Injury
por: Patschan, Daniel, et al.
Publicado: (2012)

The role of SIRT1 level and SIRT1 gene polymorphisms in optic neuritis patients with multiple sclerosis
por: Kubiliute, Aleksandra, et al.
Publicado: (2023)

Systemic Sclerosis Sera Impair Angiogenic Performance of Dermal Microvascular Endothelial Cells: Therapeutic Implications of Cyclophosphamide
por: Borghini, Annalisa, et al.
Publicado: (2015)

Autologous hematopoietic stem cell transplantation modifies specific aspects of systemic sclerosis-related microvasculopathy
por: Santana-Gonçalves, Maynara, et al.
Publicado: (2022)

Gene variants and expression changes of SIRT1 and SIRT6 in peripheral blood are associated with Parkinson’s disease
por: Maszlag-Török, Rita, et al.
Publicado: (2021)

SIRT1 Deficiency, Specifically in Fibroblasts, Decreases Apoptosis Resistance and Is Associated with Resolution of Lung-Fibrosis
por: Bulvik, Raanan, et al.
Publicado: (2020)

Blockade of CCL24 with a monoclonal antibody ameliorates experimental dermal and pulmonary fibrosis
por: Mor, Adi, et al.
Publicado: (2019)

The “myth” of loss of angiogenesis in systemic sclerosis: a pivotal early pathogenetic process or just a late unavoidable event?
por: Matucci-Cerinic, Marco, et al.
Publicado: (2017)

The Role of Endogenous Eicosapentaenoic Acid and Docosahexaenoic Acid-Derived Resolvins in Systemic Sclerosis
por: Avanoǧlu Güler, Aslıhan, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_o2ims60je89qnb2tet609ri0q6