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STAT3 Role in T-Cell Memory Formation
Along with the clinical success of immuno-oncology drugs and cellular therapies, T-cell biology has attracted considerable attention in the immunology community. Long-term immunity, traditionally analyzed in the context of infection, is increasingly studied in cancer. Many signaling pathways, transc...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910982/ https://www.ncbi.nlm.nih.gov/pubmed/35270020 http://dx.doi.org/10.3390/ijms23052878 |
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author | Kaminskiy, Yaroslav Melenhorst, Jan Joseph |
author_facet | Kaminskiy, Yaroslav Melenhorst, Jan Joseph |
author_sort | Kaminskiy, Yaroslav |
collection | PubMed |
description | Along with the clinical success of immuno-oncology drugs and cellular therapies, T-cell biology has attracted considerable attention in the immunology community. Long-term immunity, traditionally analyzed in the context of infection, is increasingly studied in cancer. Many signaling pathways, transcription factors, and metabolic regulators have been shown to participate in the formation of memory T cells. There is increasing evidence that the signal transducer and activator of transcription-3 (STAT3) signaling pathway is crucial for the formation of long-term T-cell immunity capable of efficient recall responses. In this review, we summarize what is currently known about STAT3 role in the context of memory T-cell formation and antitumor immunity. |
format | Online Article Text |
id | pubmed-8910982 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89109822022-03-11 STAT3 Role in T-Cell Memory Formation Kaminskiy, Yaroslav Melenhorst, Jan Joseph Int J Mol Sci Review Along with the clinical success of immuno-oncology drugs and cellular therapies, T-cell biology has attracted considerable attention in the immunology community. Long-term immunity, traditionally analyzed in the context of infection, is increasingly studied in cancer. Many signaling pathways, transcription factors, and metabolic regulators have been shown to participate in the formation of memory T cells. There is increasing evidence that the signal transducer and activator of transcription-3 (STAT3) signaling pathway is crucial for the formation of long-term T-cell immunity capable of efficient recall responses. In this review, we summarize what is currently known about STAT3 role in the context of memory T-cell formation and antitumor immunity. MDPI 2022-03-07 /pmc/articles/PMC8910982/ /pubmed/35270020 http://dx.doi.org/10.3390/ijms23052878 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kaminskiy, Yaroslav Melenhorst, Jan Joseph STAT3 Role in T-Cell Memory Formation |
title | STAT3 Role in T-Cell Memory Formation |
title_full | STAT3 Role in T-Cell Memory Formation |
title_fullStr | STAT3 Role in T-Cell Memory Formation |
title_full_unstemmed | STAT3 Role in T-Cell Memory Formation |
title_short | STAT3 Role in T-Cell Memory Formation |
title_sort | stat3 role in t-cell memory formation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910982/ https://www.ncbi.nlm.nih.gov/pubmed/35270020 http://dx.doi.org/10.3390/ijms23052878 |
work_keys_str_mv | AT kaminskiyyaroslav stat3roleintcellmemoryformation AT melenhorstjanjoseph stat3roleintcellmemoryformation |