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STAT3 Role in T-Cell Memory Formation

Along with the clinical success of immuno-oncology drugs and cellular therapies, T-cell biology has attracted considerable attention in the immunology community. Long-term immunity, traditionally analyzed in the context of infection, is increasingly studied in cancer. Many signaling pathways, transc...

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Detalles Bibliográficos
Autores principales: Kaminskiy, Yaroslav, Melenhorst, Jan Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910982/
https://www.ncbi.nlm.nih.gov/pubmed/35270020
http://dx.doi.org/10.3390/ijms23052878
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author Kaminskiy, Yaroslav
Melenhorst, Jan Joseph
author_facet Kaminskiy, Yaroslav
Melenhorst, Jan Joseph
author_sort Kaminskiy, Yaroslav
collection PubMed
description Along with the clinical success of immuno-oncology drugs and cellular therapies, T-cell biology has attracted considerable attention in the immunology community. Long-term immunity, traditionally analyzed in the context of infection, is increasingly studied in cancer. Many signaling pathways, transcription factors, and metabolic regulators have been shown to participate in the formation of memory T cells. There is increasing evidence that the signal transducer and activator of transcription-3 (STAT3) signaling pathway is crucial for the formation of long-term T-cell immunity capable of efficient recall responses. In this review, we summarize what is currently known about STAT3 role in the context of memory T-cell formation and antitumor immunity.
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spelling pubmed-89109822022-03-11 STAT3 Role in T-Cell Memory Formation Kaminskiy, Yaroslav Melenhorst, Jan Joseph Int J Mol Sci Review Along with the clinical success of immuno-oncology drugs and cellular therapies, T-cell biology has attracted considerable attention in the immunology community. Long-term immunity, traditionally analyzed in the context of infection, is increasingly studied in cancer. Many signaling pathways, transcription factors, and metabolic regulators have been shown to participate in the formation of memory T cells. There is increasing evidence that the signal transducer and activator of transcription-3 (STAT3) signaling pathway is crucial for the formation of long-term T-cell immunity capable of efficient recall responses. In this review, we summarize what is currently known about STAT3 role in the context of memory T-cell formation and antitumor immunity. MDPI 2022-03-07 /pmc/articles/PMC8910982/ /pubmed/35270020 http://dx.doi.org/10.3390/ijms23052878 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kaminskiy, Yaroslav
Melenhorst, Jan Joseph
STAT3 Role in T-Cell Memory Formation
title STAT3 Role in T-Cell Memory Formation
title_full STAT3 Role in T-Cell Memory Formation
title_fullStr STAT3 Role in T-Cell Memory Formation
title_full_unstemmed STAT3 Role in T-Cell Memory Formation
title_short STAT3 Role in T-Cell Memory Formation
title_sort stat3 role in t-cell memory formation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910982/
https://www.ncbi.nlm.nih.gov/pubmed/35270020
http://dx.doi.org/10.3390/ijms23052878
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