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Comparing the Occurrence of Healthcare-Associated Infections in Patients with and without COVID-19 Hospitalized during the Pandemic: A 16-Month Retrospective Cohort Study in a Hospital Intensive Care Unit
The COVID-19 pandemic has increased the healthcare-associated infection (HAI) risk in intensive care unit (ICU) patients. However, a comparison between patients with and without COVID-19 in terms of HAI incidence has been rarely explored. In this study, we characterized the occurrence of HAI among p...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910983/ https://www.ncbi.nlm.nih.gov/pubmed/35268538 http://dx.doi.org/10.3390/jcm11051446 |
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author | Isonne, Claudia Baccolini, Valentina Migliara, Giuseppe Ceparano, Mariateresa Alessandri, Francesco Ceccarelli, Giancarlo Tellan, Guglielmo Pugliese, Francesco De Giusti, Maria De Vito, Corrado Marzuillo, Carolina Villari, Paolo Barone, Lavinia Camilla Giannini, Dara Marotta, Daniela Marte, Mattia Mazzalai, Elena Germani, Irma Bellini, Arianna Bongiovanni, Andrea Castellani, Marta D’Agostino, Ludovica De Giorgi, Andrea De Marchi, Chiara Mazzeo, Elisa Orlandi, Shadi Piattoli, Matteo Ricci, Eleonora Siena, Leonardo Maria Territo, Alessandro Zanni, Stefano |
author_facet | Isonne, Claudia Baccolini, Valentina Migliara, Giuseppe Ceparano, Mariateresa Alessandri, Francesco Ceccarelli, Giancarlo Tellan, Guglielmo Pugliese, Francesco De Giusti, Maria De Vito, Corrado Marzuillo, Carolina Villari, Paolo Barone, Lavinia Camilla Giannini, Dara Marotta, Daniela Marte, Mattia Mazzalai, Elena Germani, Irma Bellini, Arianna Bongiovanni, Andrea Castellani, Marta D’Agostino, Ludovica De Giorgi, Andrea De Marchi, Chiara Mazzeo, Elisa Orlandi, Shadi Piattoli, Matteo Ricci, Eleonora Siena, Leonardo Maria Territo, Alessandro Zanni, Stefano |
author_sort | Isonne, Claudia |
collection | PubMed |
description | The COVID-19 pandemic has increased the healthcare-associated infection (HAI) risk in intensive care unit (ICU) patients. However, a comparison between patients with and without COVID-19 in terms of HAI incidence has been rarely explored. In this study, we characterized the occurrence of HAI among patients with and without COVID-19 admitted to the ICU of the Umberto I hospital of Rome during the first 16 months of the pandemic and also identified risk factors for HAI acquisition. Patients were divided into four groups according to their ICU admission date. A multivariable conditional risk set regression model for multiple events was constructed for each admission period. Adjusted hazard ratios and 95% confidence intervals were calculated. Overall, 352 COVID-19 and 130 non-COVID-19 patients were included, and a total of 361 HAIs were recorded. We found small differences between patients with and without COVID-19 in the occurrence and type of HAI, but the infections in the two cohorts mostly involved different microorganisms. The results indicate that patient management was likely an important factor influencing the HAI occurrence during the pandemic. Effective prevention and control strategies to reduce HAI rates should be implemented. |
format | Online Article Text |
id | pubmed-8910983 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89109832022-03-11 Comparing the Occurrence of Healthcare-Associated Infections in Patients with and without COVID-19 Hospitalized during the Pandemic: A 16-Month Retrospective Cohort Study in a Hospital Intensive Care Unit Isonne, Claudia Baccolini, Valentina Migliara, Giuseppe Ceparano, Mariateresa Alessandri, Francesco Ceccarelli, Giancarlo Tellan, Guglielmo Pugliese, Francesco De Giusti, Maria De Vito, Corrado Marzuillo, Carolina Villari, Paolo Barone, Lavinia Camilla Giannini, Dara Marotta, Daniela Marte, Mattia Mazzalai, Elena Germani, Irma Bellini, Arianna Bongiovanni, Andrea Castellani, Marta D’Agostino, Ludovica De Giorgi, Andrea De Marchi, Chiara Mazzeo, Elisa Orlandi, Shadi Piattoli, Matteo Ricci, Eleonora Siena, Leonardo Maria Territo, Alessandro Zanni, Stefano J Clin Med Article The COVID-19 pandemic has increased the healthcare-associated infection (HAI) risk in intensive care unit (ICU) patients. However, a comparison between patients with and without COVID-19 in terms of HAI incidence has been rarely explored. In this study, we characterized the occurrence of HAI among patients with and without COVID-19 admitted to the ICU of the Umberto I hospital of Rome during the first 16 months of the pandemic and also identified risk factors for HAI acquisition. Patients were divided into four groups according to their ICU admission date. A multivariable conditional risk set regression model for multiple events was constructed for each admission period. Adjusted hazard ratios and 95% confidence intervals were calculated. Overall, 352 COVID-19 and 130 non-COVID-19 patients were included, and a total of 361 HAIs were recorded. We found small differences between patients with and without COVID-19 in the occurrence and type of HAI, but the infections in the two cohorts mostly involved different microorganisms. The results indicate that patient management was likely an important factor influencing the HAI occurrence during the pandemic. Effective prevention and control strategies to reduce HAI rates should be implemented. MDPI 2022-03-07 /pmc/articles/PMC8910983/ /pubmed/35268538 http://dx.doi.org/10.3390/jcm11051446 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Isonne, Claudia Baccolini, Valentina Migliara, Giuseppe Ceparano, Mariateresa Alessandri, Francesco Ceccarelli, Giancarlo Tellan, Guglielmo Pugliese, Francesco De Giusti, Maria De Vito, Corrado Marzuillo, Carolina Villari, Paolo Barone, Lavinia Camilla Giannini, Dara Marotta, Daniela Marte, Mattia Mazzalai, Elena Germani, Irma Bellini, Arianna Bongiovanni, Andrea Castellani, Marta D’Agostino, Ludovica De Giorgi, Andrea De Marchi, Chiara Mazzeo, Elisa Orlandi, Shadi Piattoli, Matteo Ricci, Eleonora Siena, Leonardo Maria Territo, Alessandro Zanni, Stefano Comparing the Occurrence of Healthcare-Associated Infections in Patients with and without COVID-19 Hospitalized during the Pandemic: A 16-Month Retrospective Cohort Study in a Hospital Intensive Care Unit |
title | Comparing the Occurrence of Healthcare-Associated Infections in Patients with and without COVID-19 Hospitalized during the Pandemic: A 16-Month Retrospective Cohort Study in a Hospital Intensive Care Unit |
title_full | Comparing the Occurrence of Healthcare-Associated Infections in Patients with and without COVID-19 Hospitalized during the Pandemic: A 16-Month Retrospective Cohort Study in a Hospital Intensive Care Unit |
title_fullStr | Comparing the Occurrence of Healthcare-Associated Infections in Patients with and without COVID-19 Hospitalized during the Pandemic: A 16-Month Retrospective Cohort Study in a Hospital Intensive Care Unit |
title_full_unstemmed | Comparing the Occurrence of Healthcare-Associated Infections in Patients with and without COVID-19 Hospitalized during the Pandemic: A 16-Month Retrospective Cohort Study in a Hospital Intensive Care Unit |
title_short | Comparing the Occurrence of Healthcare-Associated Infections in Patients with and without COVID-19 Hospitalized during the Pandemic: A 16-Month Retrospective Cohort Study in a Hospital Intensive Care Unit |
title_sort | comparing the occurrence of healthcare-associated infections in patients with and without covid-19 hospitalized during the pandemic: a 16-month retrospective cohort study in a hospital intensive care unit |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910983/ https://www.ncbi.nlm.nih.gov/pubmed/35268538 http://dx.doi.org/10.3390/jcm11051446 |
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