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Human Amniotic Membrane for the Treatment of Cryptoglandular Anal Fistulas
Background: Implantation of the amniotic membrane and their derivatives can have a beneficial effect on tissue repair and regeneration. We report for the first time the implant of an amniotic membrane in a patient affected by cryptoglandular anal fistula. Methods: A patch of human amniotic membrane...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911009/ https://www.ncbi.nlm.nih.gov/pubmed/35268442 http://dx.doi.org/10.3390/jcm11051350 |
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author | Ratto, Carlo Parolini, Ornella Marra, Angelo Alessandro Orticelli, Valentina Parello, Angelo Campennì, Paola De Simone, Veronica Trojan, Diletta Litta, Francesco |
author_facet | Ratto, Carlo Parolini, Ornella Marra, Angelo Alessandro Orticelli, Valentina Parello, Angelo Campennì, Paola De Simone, Veronica Trojan, Diletta Litta, Francesco |
author_sort | Ratto, Carlo |
collection | PubMed |
description | Background: Implantation of the amniotic membrane and their derivatives can have a beneficial effect on tissue repair and regeneration. We report for the first time the implant of an amniotic membrane in a patient affected by cryptoglandular anal fistula. Methods: A patch of human amniotic membrane was implanted in a female patient affected by an anterior transphincteric fistula. Following an accurate curettage of the anal fistula, the cryopreserved amniotic membrane was thawed and then washed in the operating room; one side of the membrane was transfixed with a resorbable suture thus creating an implantable fusiform patch. The membrane was subsequently implanted into the fistula tract from the external to the internal opening. The inner and outer parts of the membrane were then sutured to the internal and external fistula openings. Results: No intraoperative or postoperative complications occurred. The patient was discharged one day after the procedure after an uneventful hospitalization. At the 1-week, 1- and 3-month follow-up visits no pain (VAS 0) was referred by the patient and no inflammation was evident at the level of the previous external fistula opening. Conclusions: The implant of human amniotic membrane in a patient affected by cryptoglandular anal fistula was safely and easily performed. Moreover, future studies to assess the efficacy in the long-term follow-up are needed. |
format | Online Article Text |
id | pubmed-8911009 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89110092022-03-11 Human Amniotic Membrane for the Treatment of Cryptoglandular Anal Fistulas Ratto, Carlo Parolini, Ornella Marra, Angelo Alessandro Orticelli, Valentina Parello, Angelo Campennì, Paola De Simone, Veronica Trojan, Diletta Litta, Francesco J Clin Med Technical Note Background: Implantation of the amniotic membrane and their derivatives can have a beneficial effect on tissue repair and regeneration. We report for the first time the implant of an amniotic membrane in a patient affected by cryptoglandular anal fistula. Methods: A patch of human amniotic membrane was implanted in a female patient affected by an anterior transphincteric fistula. Following an accurate curettage of the anal fistula, the cryopreserved amniotic membrane was thawed and then washed in the operating room; one side of the membrane was transfixed with a resorbable suture thus creating an implantable fusiform patch. The membrane was subsequently implanted into the fistula tract from the external to the internal opening. The inner and outer parts of the membrane were then sutured to the internal and external fistula openings. Results: No intraoperative or postoperative complications occurred. The patient was discharged one day after the procedure after an uneventful hospitalization. At the 1-week, 1- and 3-month follow-up visits no pain (VAS 0) was referred by the patient and no inflammation was evident at the level of the previous external fistula opening. Conclusions: The implant of human amniotic membrane in a patient affected by cryptoglandular anal fistula was safely and easily performed. Moreover, future studies to assess the efficacy in the long-term follow-up are needed. MDPI 2022-03-01 /pmc/articles/PMC8911009/ /pubmed/35268442 http://dx.doi.org/10.3390/jcm11051350 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Technical Note Ratto, Carlo Parolini, Ornella Marra, Angelo Alessandro Orticelli, Valentina Parello, Angelo Campennì, Paola De Simone, Veronica Trojan, Diletta Litta, Francesco Human Amniotic Membrane for the Treatment of Cryptoglandular Anal Fistulas |
title | Human Amniotic Membrane for the Treatment of Cryptoglandular Anal Fistulas |
title_full | Human Amniotic Membrane for the Treatment of Cryptoglandular Anal Fistulas |
title_fullStr | Human Amniotic Membrane for the Treatment of Cryptoglandular Anal Fistulas |
title_full_unstemmed | Human Amniotic Membrane for the Treatment of Cryptoglandular Anal Fistulas |
title_short | Human Amniotic Membrane for the Treatment of Cryptoglandular Anal Fistulas |
title_sort | human amniotic membrane for the treatment of cryptoglandular anal fistulas |
topic | Technical Note |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911009/ https://www.ncbi.nlm.nih.gov/pubmed/35268442 http://dx.doi.org/10.3390/jcm11051350 |
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