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Human Amniotic Membrane for the Treatment of Cryptoglandular Anal Fistulas

Background: Implantation of the amniotic membrane and their derivatives can have a beneficial effect on tissue repair and regeneration. We report for the first time the implant of an amniotic membrane in a patient affected by cryptoglandular anal fistula. Methods: A patch of human amniotic membrane...

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Autores principales: Ratto, Carlo, Parolini, Ornella, Marra, Angelo Alessandro, Orticelli, Valentina, Parello, Angelo, Campennì, Paola, De Simone, Veronica, Trojan, Diletta, Litta, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911009/
https://www.ncbi.nlm.nih.gov/pubmed/35268442
http://dx.doi.org/10.3390/jcm11051350
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author Ratto, Carlo
Parolini, Ornella
Marra, Angelo Alessandro
Orticelli, Valentina
Parello, Angelo
Campennì, Paola
De Simone, Veronica
Trojan, Diletta
Litta, Francesco
author_facet Ratto, Carlo
Parolini, Ornella
Marra, Angelo Alessandro
Orticelli, Valentina
Parello, Angelo
Campennì, Paola
De Simone, Veronica
Trojan, Diletta
Litta, Francesco
author_sort Ratto, Carlo
collection PubMed
description Background: Implantation of the amniotic membrane and their derivatives can have a beneficial effect on tissue repair and regeneration. We report for the first time the implant of an amniotic membrane in a patient affected by cryptoglandular anal fistula. Methods: A patch of human amniotic membrane was implanted in a female patient affected by an anterior transphincteric fistula. Following an accurate curettage of the anal fistula, the cryopreserved amniotic membrane was thawed and then washed in the operating room; one side of the membrane was transfixed with a resorbable suture thus creating an implantable fusiform patch. The membrane was subsequently implanted into the fistula tract from the external to the internal opening. The inner and outer parts of the membrane were then sutured to the internal and external fistula openings. Results: No intraoperative or postoperative complications occurred. The patient was discharged one day after the procedure after an uneventful hospitalization. At the 1-week, 1- and 3-month follow-up visits no pain (VAS 0) was referred by the patient and no inflammation was evident at the level of the previous external fistula opening. Conclusions: The implant of human amniotic membrane in a patient affected by cryptoglandular anal fistula was safely and easily performed. Moreover, future studies to assess the efficacy in the long-term follow-up are needed.
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spelling pubmed-89110092022-03-11 Human Amniotic Membrane for the Treatment of Cryptoglandular Anal Fistulas Ratto, Carlo Parolini, Ornella Marra, Angelo Alessandro Orticelli, Valentina Parello, Angelo Campennì, Paola De Simone, Veronica Trojan, Diletta Litta, Francesco J Clin Med Technical Note Background: Implantation of the amniotic membrane and their derivatives can have a beneficial effect on tissue repair and regeneration. We report for the first time the implant of an amniotic membrane in a patient affected by cryptoglandular anal fistula. Methods: A patch of human amniotic membrane was implanted in a female patient affected by an anterior transphincteric fistula. Following an accurate curettage of the anal fistula, the cryopreserved amniotic membrane was thawed and then washed in the operating room; one side of the membrane was transfixed with a resorbable suture thus creating an implantable fusiform patch. The membrane was subsequently implanted into the fistula tract from the external to the internal opening. The inner and outer parts of the membrane were then sutured to the internal and external fistula openings. Results: No intraoperative or postoperative complications occurred. The patient was discharged one day after the procedure after an uneventful hospitalization. At the 1-week, 1- and 3-month follow-up visits no pain (VAS 0) was referred by the patient and no inflammation was evident at the level of the previous external fistula opening. Conclusions: The implant of human amniotic membrane in a patient affected by cryptoglandular anal fistula was safely and easily performed. Moreover, future studies to assess the efficacy in the long-term follow-up are needed. MDPI 2022-03-01 /pmc/articles/PMC8911009/ /pubmed/35268442 http://dx.doi.org/10.3390/jcm11051350 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Technical Note
Ratto, Carlo
Parolini, Ornella
Marra, Angelo Alessandro
Orticelli, Valentina
Parello, Angelo
Campennì, Paola
De Simone, Veronica
Trojan, Diletta
Litta, Francesco
Human Amniotic Membrane for the Treatment of Cryptoglandular Anal Fistulas
title Human Amniotic Membrane for the Treatment of Cryptoglandular Anal Fistulas
title_full Human Amniotic Membrane for the Treatment of Cryptoglandular Anal Fistulas
title_fullStr Human Amniotic Membrane for the Treatment of Cryptoglandular Anal Fistulas
title_full_unstemmed Human Amniotic Membrane for the Treatment of Cryptoglandular Anal Fistulas
title_short Human Amniotic Membrane for the Treatment of Cryptoglandular Anal Fistulas
title_sort human amniotic membrane for the treatment of cryptoglandular anal fistulas
topic Technical Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911009/
https://www.ncbi.nlm.nih.gov/pubmed/35268442
http://dx.doi.org/10.3390/jcm11051350
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