Cargando…
Multi-Omics Analysis in β-Thalassemia Using an HBB Gene-Knockout Human Erythroid Progenitor Cell Model
β-thalassemia is a hematologic disease that may be associated with significant morbidity and mortality. Increased expression of HBG1/2 can ameliorate the severity of β-thalassemia. Compared to the unaffected population, some β-thalassemia patients display elevated HBG1/2 expression levels in their r...
Autores principales: | Zhou, Guoqiang, Zhang, Haokun, Lin, Anning, Wu, Zhen, Li, Ting, Zhang, Xumin, Chen, Hongyan, Lu, Daru |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911073/ https://www.ncbi.nlm.nih.gov/pubmed/35269949 http://dx.doi.org/10.3390/ijms23052807 |
Ejemplares similares
-
Prime Editor 3 Mediated Beta-Thalassemia Mutations of the HBB Gene in Human Erythroid Progenitor Cells
por: Zhang, Haokun, et al.
Publicado: (2022) -
HBB-deficient Macaca fascicularis monkey presents with human β-thalassemia
por: Huang, Yan, et al.
Publicado: (2019) -
Two Rare Pathogenic HBB Variants in a Patient with β-Thalassemia Intermedia
por: Hançer, Veysel Sabri, et al.
Publicado: (2020) -
Correction of Beta-Thalassemia IVS-II-654 Mutation in a Mouse Model Using Prime Editing
por: Zhang, Haokun, et al.
Publicado: (2022) -
Both TALENs and CRISPR/Cas9 directly target the HBB IVS2–654 (C > T) mutation in β-thalassemia-derived iPSCs
por: Xu, Peng, et al.
Publicado: (2015)