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Ventx Family and Its Functional Similarities with Nanog: Involvement in Embryonic Development and Cancer Progression

The Ventx family is one of the subfamilies of the ANTP (antennapedia) superfamily and belongs to the NK-like (NKL) subclass. Ventx is a homeobox transcription factor and has a DNA-interacting domain that is evolutionarily conserved throughout vertebrates. It has been extensively studied in Xenopus,...

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Autores principales: Kumar, Shiv, Kumar, Vijay, Li, Wenchang, Kim, Jaebong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911082/
https://www.ncbi.nlm.nih.gov/pubmed/35269883
http://dx.doi.org/10.3390/ijms23052741
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author Kumar, Shiv
Kumar, Vijay
Li, Wenchang
Kim, Jaebong
author_facet Kumar, Shiv
Kumar, Vijay
Li, Wenchang
Kim, Jaebong
author_sort Kumar, Shiv
collection PubMed
description The Ventx family is one of the subfamilies of the ANTP (antennapedia) superfamily and belongs to the NK-like (NKL) subclass. Ventx is a homeobox transcription factor and has a DNA-interacting domain that is evolutionarily conserved throughout vertebrates. It has been extensively studied in Xenopus, zebrafish, and humans. The Ventx family contains transcriptional repressors widely involved in embryonic development and tumorigenesis in vertebrates. Several studies have documented that the Ventx family inhibited dorsal mesodermal formation, neural induction, and head formation in Xenopus and zebrafish. Moreover, Ventx2.2 showed functional similarities to Nanog and Barx1, leading to pluripotency and neural-crest migration in vertebrates. Among them, Ventx protein is an orthologue of the Ventx family in humans. Studies have demonstrated that human Ventx was strongly associated with myeloid-cell differentiation and acute myeloid leukemia. The therapeutic potential of Ventx family inhibition in combating cancer progression in humans is discussed. Additionally, we briefly discuss genome evolution, gene duplication, pseudo-allotetraploidy, and the homeobox family in Xenopus.
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spelling pubmed-89110822022-03-11 Ventx Family and Its Functional Similarities with Nanog: Involvement in Embryonic Development and Cancer Progression Kumar, Shiv Kumar, Vijay Li, Wenchang Kim, Jaebong Int J Mol Sci Review The Ventx family is one of the subfamilies of the ANTP (antennapedia) superfamily and belongs to the NK-like (NKL) subclass. Ventx is a homeobox transcription factor and has a DNA-interacting domain that is evolutionarily conserved throughout vertebrates. It has been extensively studied in Xenopus, zebrafish, and humans. The Ventx family contains transcriptional repressors widely involved in embryonic development and tumorigenesis in vertebrates. Several studies have documented that the Ventx family inhibited dorsal mesodermal formation, neural induction, and head formation in Xenopus and zebrafish. Moreover, Ventx2.2 showed functional similarities to Nanog and Barx1, leading to pluripotency and neural-crest migration in vertebrates. Among them, Ventx protein is an orthologue of the Ventx family in humans. Studies have demonstrated that human Ventx was strongly associated with myeloid-cell differentiation and acute myeloid leukemia. The therapeutic potential of Ventx family inhibition in combating cancer progression in humans is discussed. Additionally, we briefly discuss genome evolution, gene duplication, pseudo-allotetraploidy, and the homeobox family in Xenopus. MDPI 2022-03-01 /pmc/articles/PMC8911082/ /pubmed/35269883 http://dx.doi.org/10.3390/ijms23052741 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kumar, Shiv
Kumar, Vijay
Li, Wenchang
Kim, Jaebong
Ventx Family and Its Functional Similarities with Nanog: Involvement in Embryonic Development and Cancer Progression
title Ventx Family and Its Functional Similarities with Nanog: Involvement in Embryonic Development and Cancer Progression
title_full Ventx Family and Its Functional Similarities with Nanog: Involvement in Embryonic Development and Cancer Progression
title_fullStr Ventx Family and Its Functional Similarities with Nanog: Involvement in Embryonic Development and Cancer Progression
title_full_unstemmed Ventx Family and Its Functional Similarities with Nanog: Involvement in Embryonic Development and Cancer Progression
title_short Ventx Family and Its Functional Similarities with Nanog: Involvement in Embryonic Development and Cancer Progression
title_sort ventx family and its functional similarities with nanog: involvement in embryonic development and cancer progression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911082/
https://www.ncbi.nlm.nih.gov/pubmed/35269883
http://dx.doi.org/10.3390/ijms23052741
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